Category Archives: Medical research

At 75, I’ve volunteered for a Covid vaccine trial. It could set people free

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Some of my friends think I’m mad but we need to know people my age can go out safely again

There’s a 50% chance that this week I was injected with a vaccine designed to protect me from Covid-19. If not, I got the saltwater placebo instead. I won’t know until the study ends in 13 months, which is a shame. It would be nice to walk the streets without looking balefully around me at young people not wearing masks and thinking: I’m 75, this virus kills people my age.

It killed my chum Mike Pentelow, who was having a lot of fun in his retirement, writing books with titles such as A Pub Crawl Through History, and Mike was a year younger than me. Perhaps he’s the reason I volunteered to be a guinea pig for one of the companies working on a vaccine.

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Queensland investigates Covid-19 strain on cargo ship after New Zealand alert

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MV Sofrana Surville barred from docking after officials in New Zealand said crew members on departing cargo ship might have new strain

Queensland health officials are working to determine the strain of Covid-19 infecting the crew of a cargo ship anchored off the Australian state’s Sunshine Coast.

The MV Sofrana Surville was blocked from docking in Brisbane after New Zealand warned it could be carrying a new strain of the virus.

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Wash your mask daily: the ultimate guide to face coverings

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Experts explain the best way to wash masks, how to handle them – and how to prevent ‘maskne’

We hook them on to our faces, laugh, sneeze and sputter into them, then crumple them into our bags or pockets only to retrieve them and do it all again. Yet despite official advice that we should be wearing a fresh face covering each time we enter an enclosed public space, a YouGov poll revealed many people are going several wears between washes – and 15% of Brits don’t wash their reusable masks at all. Similarly, more than half of those opting for disposable masks are rewearing them – 7% of them indefinitely so.

Face coverings are designed to catch the respiratory droplets we emit from our mouths and noses, but given that they’re our own respiratory droplets, is this really so bad? We examine the evidence.

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Women aged 50-60 at greatest risk of ‘long Covid’, experts suggest

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Study links age and number of symptoms to lasting health problems from coronavirus

Women aged 50-60 are at greatest risk of developing “long Covid”, analysis suggests. Older age and experiencing five or more symptoms within the first week of illness were also associated with a heightened risk of lasting health problems.

The study, led by Dr Claire Steves and Prof Tim Spector at King’s College London, analysed data from 4,182 COVID Symptom Study app users who had been consistently logging their health and had tested positive for the virus.

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Covid-19: what can we learn from the HIV/Aids pandemic? – podcast

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Prof Ravi Gupta’s career has informed HIV treatment and curative strategies in the UK and at the Africa Health Research Institute. His treatment of a London patient is, to date, only the second ever successful treatment of an HIV patient, where the person remains long-term virus free. Gupta talks to Sarah Boseley about how a career in HIV research is informing the testing and treatment for Covid-19 and what we can learn in any parallels between the two viruses

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Digital ‘health passport’ trials under way to aid reopening of borders

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CommonPass aims to create common standard proving a traveller is Covid-free or vaccinated

A new digital “health passport” is to be piloted by a small number of passengers flying from the UK to the US for the first time next week under plans for a global framework for Covid-safe air travel.

The CommonPass system, backed by the World Economic Forum (WEF), is designed to create a common international standard for passengers to demonstrate they do not have coronavirus.

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Curing the incurable: teaching an old drug new tricks to fight ovarian cancer

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The winning essay in the Max Perutz science writing award 2020 was written by Sarah Taylor from the MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh

In May, PhD students who are funded by the Medical Research Council (MRC) were invited to enter the Max Perutz science writing award 2020 and to tell the general public “why your research matters”. From the many entries received, the 10 that made the shortlist covered diverse topics, including motor neurone disease, self-harm, babies’ experiences of pain, and bone loss resulting from space travel.

The essays were judged by the Observer’s Ian Tucker, the Science Museum’s Roger Highfield, Prof Fiona Watt from the MRC, Bristol University’s Andy Ridgeway and the journalist and broadcaster Samira Ahmed.

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Covid reinfections ‘to be expected’ as virus spreads, say government scientists

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Reports suggest timeframe between recovery and reinfection ‘relatively short’ for those who contracted virus twice

Government science advisers have warned that reinfections with Covid-19 are “to be expected” as the virus spreads, based on what is known about people’s immunity to other coronaviruses that cause the common cold.

Researchers on the Covid-19 Genomics UK Consortium said it was unclear at what point people who had recovered from the virus became vulnerable to reinfection, but cited emerging reports of second infections that suggested the timeframe was “relatively short”.

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Remdesivir has very little effect on Covid-19 mortality, WHO finds

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Results of major trial described as sobering, with drug found not to improve survival rates

Remdesivir, one of the big treatment hopes for Covid-19, has very little effect on preventing deaths, according to a large and comprehensive trial run by the World Health Organization.

The drug, made by the US biotech firm Gilead, has been talked up as a potential cure and was taken by Donald Trump. A trial in the US had previously showed it reduced the length of stay in hospital. But the gold-standard Solidarity WHO trial, which was based on a far larger sample – 3,000 people on the drug, compared with as many who were not – showed remdesivir had little effect on deaths over 28 days.

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Third of newborns with Covid infected before or during birth – study

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Review of reported neonatal cases finds most babies with virus contract it in hospital

Nearly a third of coronavirus infections in newborn babies are picked up in the womb or from the mother during labour, a review of reported cases has found.

While Covid-19 is rare in newborns, doctors have been keen to understand the potential risks that babies face should tests reveal they have the infection soon after birth.

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Long Covid: what we know so far

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Lasting symptoms may not be down to a single syndrome but several different ones

At the start of the pandemic we were told that Covid-19 was a respiratory illness from which most people would recover within two or three weeks, but it’s increasingly clear that there may be tens of thousands of people, if not hundreds of thousands, who have been left experiencing symptoms months after becoming infected.

Now, the National Institute for Health Research (NIHR) has released a report which suggests that “long Covid” may not be a single syndrome, but up to four different ones, which some patients might be experiencing simultaneously. Here’s what we now know:

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UK’s test and trace ‘having marginal impact’: which countries got it right?

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Scientists’ verdict on £12bn system has refocused attention on what is working elsewhere in cutting Covid-19 transmission rates

The newly released assessment by the UK government’s scientific advisers that the £12bn test and trace programme “is having a marginal impact” in reducing Covid-19 transmission has refocused attention on how other countries are faring with their regimes.

Since test-and-trace programmes were first mooted around the world at the outset of the pandemic – including monitoring via apps or hardware – they have been beset by issues of privacy and public support over both downloading and using apps and also with a wider willingness to abide by isolation measures.

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UK coronavirus live: Covid deaths in England and Wales quadrupled in a month, ONS figures show

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Latest updates: minister says Covid restrictions require ‘difficult judgment’ of protecting lives while prioritising education and jobs

The Department for Education’s latest school attendance statistics show an increase in the number of state schools in England partially closed because of Covid-19.

More than one in five state secondaries reported being partially closed, meaning that classes or year groups were sent home or were isolating. Previously 82% were classed as “fully open” but last week the proportion fell to 79%.

Attendance in fully open primary schools is now consistent with what we would have expected before coronavirus. Across all state schools, only a small minority of pupils are self-isolating and schools are providing remote education, in line with what pupils would be receiving in school.

We will continue to work with schools to ensure all appropriate steps are taken to keep pupils and staff safe.

A pilot scheme will be launched “shortly” in England which will involve relatives of care home residents being treated as key workers to enable safe visits, Helen Whately, the care minister, has said.

Giving evidence to the joint science and health committee hearing on coronavirus, she said she wanted to enable visiting “but it must be safe”.

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Virus that causes Covid-19 can survive up to 28 days on surfaces, scientists find

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Researchers find Sars-CoV-2 survives longer at lower temperatures and lasts 10 days longer than influenza on some surfaces

Australian scientists have found that the virus that causes Covid-19 can survive for up to 28 days on surfaces such as the glass on mobile phones, stainless steel, vinyl and paper banknotes.

The national science agency, the CSIRO, said the research undertaken at the Australian Centre for Disease Preparedness (ACDP) in Geelong also found that Sars-CoV-2 survived longer at lower temperatures.

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Iain Duncan Smith calls for review of Chinese investment in UK

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Former Conservative leader says government should assess China’s influence in areas from 5G to Covid-19 research

Chinese ownership of British businesses should be subject to a national security review by the UK government to assess the impact of Beijing’s growing economic power, according to the former Conservative leader Iain Duncan Smith.

The senior backbencher – a leading figure in the rebellion that forced Downing Street to introduce tougher controls on Huawei – believes ministers have failed to deal with the scale of China’s influence on strategic industries in the UK.

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Would herd immunity stop the spread of coronavirus?

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Even if achievable, the strategy would kill too many people, say scientists

Like the Covid-19 virus itself, the idea of herd immunity has surged back into public life having been suppressed for months. It was initially touted as a way to hold back the pandemic – by allowing sufficient numbers of infections to occur and so reduce numbers of non-immune potential hosts for the virus. The disease would then stop spreading, it was argued.

The notion quickly fell out of favour when researchers highlighted the high death toll that would have to occur in the UK before herd immunity was achieved. Nevertheless, the idea has now bubbled back and is again making headlines.

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The race for a Covid vaccine: inside the Australian lab working round the clock to produce 100m doses

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The Guardian is given a unique insight into the operations of CSL, which is making vaccines that could help end the crisis

Some call it the “happy soup”.

Take a dash of modified Covid-19 protein DNA, mix it with cells from a Chinese hamster’s ovary, and place the combination in two state-of-the-art 2,000L bioreactors in a sprawling scientific facility on Melbourne’s northern fringes.

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Herd immunity letter signed by fake experts including ‘Dr Johnny Bananas’

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Open letter calling for new Covid-19 strategy also signed by ‘Prof Cominic Dummings’

An open letter that made headlines calling for a herd immunity approach to Covid-19 lists a number of apparently fake names among its expert signatories, including “Dr Johnny Bananas” and “Professor Cominic Dummings”.

The Great Barrington declaration, which was said to have been signed by more than 15,000 scientists and medical practitioners around the world, was found by Sky News to contain numerous false names, as well as those of several homeopaths.

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BAME groups hit hard again as Covid second wave grips UK nations

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As cases surge, figures show the demographics of those most seriously affected by coronavirus remain the same

One of the earliest signs that black, Asian and minority ethnic (BAME) people were being disproportionately harmed by the coronavirus pandemic came when the Intensive Care National Audit and Research Centre (ICNAR) published research in early April showing that 35% of almost 2,000 Covid patients in intensive care units in England, Wales and Northern Ireland were non-white.

A lot has happened in the intervening six months with numerous reports, including by the Office for National Statistics and Public Health England (PHE), confirming the increased risk to ethnic minorities and recommendations published on how to mitigate that risk. However, as the second wave intensifies, the demographics of those most seriously affected remain remarkably similar.

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‘Brain fog’: the people struggling to think clearly months after Covid

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Doctors grapple for answers as more patients report post-coronavirus cognitive impairment

For Mirabai Nicholson-McKellar, Covid-19 brought an onslaught of symptoms from chest pains to an 11-day migraine, three positive test results, and a period in hospital.

Seven months later, the rollercoaster is far from over: the 36-year-old from Byron Bay, Australia is still experiencing symptoms – including difficulties with thinking that are often described as “brain fog”.

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