The science of senolytics: how a new pill could spell the end of ageing

A simple treatment to stave off the health problems of old age could be available in five to 12 years. Here’s how it would work

The science of extending life is a subject of morbid fascination, conjuring the image of old billionaires being cryogenically frozen. But imagine if, instead of a pill you could take to live for ever, there was a pill that could push back the ageing process – a medicine that could stave off the fragility, osteoarthritis, memory loss, macular degeneration and cancers that plague old age.

It could happen, with the science of senolytics: an emerging – and highly anticipated – area of anti-ageing medicine. Many of the world’s top gerontologists have already demonstrated the possibilities in animals and are now beginning human clinical trials, with promising results. If the studies continue to be as successful as hoped, those who are currently middle-aged could become the first generation of oldies who are youthful for longer – with a little medical help.

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Scientists discover way to ‘grow’ tooth enamel

Experts produce clusters of enamel-like calcium phosphate to crack age-old problem

Scientists say they have finally cracked the problem of repairing tooth enamel.

Though enamel is the hardest tissue in the body, it cannot self-repair. Now scientists have discovered a method by which its complex structure can be reproduced and the enamel essentially “grown” back.

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‘It’s a big deal’: Trump takes giant leap in space command launch

President detailed operations in ceremony, including defending against Chinese and Russian anti-satellite weapons, and promised space force will soon follow

It was one small step for man, one giant leap for Trumpkind.

Donald Trump made the short journey on Thursday from the Oval Office to the White House Rose Garden, then promised to unleash an army of space warriors to infinity and beyond.

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Breast cancer risk from using HRT is ‘twice what was thought’

Study prompts medicines regulator to advise all women using HRT to remain vigilant

The risk of breast cancer from using hormone replacement therapy is double what was previously thought, according to a major piece of research, which confirms that HRT is a direct cause of the cancer.

The findings of the definitive study will cause concern among the 1 million women in the UK and millions more around the world who are using HRT. It finds that the longer women take it, the greater their risk, with the possibility that just one year is risk-free. It also finds that the risk does not go away as soon as women stop taking it, as had been previously assumed.

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Scientists quash idea of single ‘gay gene’

Many genetic variants each play role in homosexual behaviour, study finds

A vast new study has quashed the idea that a single “gay gene” exists, scientists say, instead finding homosexual behaviour is influenced by a multitude of genetic variants which each have a tiny effect.

The researchers compare the situation to factors determining a person’s height, in which multiple genetic and environmental factors play roles.

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No-fly zone: Russian space suit redesign halts lucky pee ritual

Astronauts will no longer be able to urinate on bus that picks them up for launch

Russia has unveiled a new space suit but the design may have to be changed to continue a decades-old tradition – making a stop to pee on the way to the launch.

The Sokol-M prototype suit was designed as a replacement for suits worn during launches to the International Space Station (ISS) on Soyuz spacecraft.

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Peru: skeletons of 227 victims unearthed at world’s largest child sacrifice site

Experts believe the children were sacrificed by the Chimú culture to appease the El Niño phenomenon

Archaeologists excavating what is thought to be the world’s largest child sacrifice site have unearthed the skeletons of 227 young victims in the coastal desert of northern Peru.

Teams have been digging since last year at the sacrificial site in Huanchaco, a beachside tourist town close to Trujillo, Peru’s third largest city.

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Optimism may hold secret to longer life, study suggests

Research claims people who ‘look on the bright side’ stand better chance of reaching 85

Seeing the glass as half full may mean a longer life, according to research suggesting that optimists not only live longer in general, but have a better chance of reaching 85 or older.

It is not the first time optimism has been linked to health benefits. People of an upbeat disposition have previously been found to have a lower risk of heart conditions and premature death. Researchers now say it could also play a role in living a long life.

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Microplastics in water not harmful to humans, says WHO report

Experts find no proof minuscule particles are a threat to health but say more research is needed

Microplastics are increasingly found in drinking water, but there is no evidence so far that this poses a risk to humans, according to a new assessment by the World Health Organization.

However, the United Nations body warned against complacency because more research is needed to fully understand how plastic spreads into the environment and works its way through human bodies.

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Older adults can boost longevity ‘with just a little exercise’

Norwegian review of 36,000 cases links more activity overall, light or intensive, with lower risk of death

Even a small increase in light activity, such as washing dishes, a little gentle gardening, or shuffling around the house, might help stave off an early death among older adults, researchers say.

Being sedentary, for instance, by sitting for long periods of time, has been linked to an increased risk of developing many conditions, including heart disease, as well as an early death.

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New species of stegosaurus uncovered in Moroccan dig

Scientists believe dinosaur dates back to 168m years ago during the middle Jurassic period

A new species of one of the most recognisable types of dinosaur is also the oldest of its kind ever discovered, British scientists believe.

Remains of a stegosaurus, an armoured dinosaur instantly recognisable by the plate-like bones protruding from its spine and spikes on its tails, were studied by a team from the Natural History Museum and belong to a new genus that walked the earth around 168m years ago.

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Maths and tech specialists need Hippocratic oath, says academic

Exclusive: Hannah Fry says ethical pledge needed in tech fields that will shape future

Mathematicians, computer engineers and scientists in related fields should take a Hippocratic oath to protect the public from powerful new technologies under development in laboratories and tech firms, a leading researcher has said.

The ethical pledge would commit scientists to think deeply about the possible applications of their work and compel them to pursue only those that, at the least, do no harm to society.

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One giant leap for Indian cinema: how Bollywood embraced sci-fi

As the country seeks to establish itself as a space power, audiences are developing an appetite for the extraterrestrial on the big screen

In 2014, India sent the Mars Orbiter Mission into space, and became the first country to send a satellite to orbit the planet at its first attempt – putting its much richer regional rival China in the shade as it became the first Asian nation to get to the red planet. The project was notable for being led by a team of female scientists; as is India’s second lunar probe, Chandrayaan-2 (from the Sanskrit for “moon craft”), which was launched last month and is due to land on the moon in early September. And as the country establishes itself as a space power, Indians have developed an appetite for sci-fi themes in its cinema.

The patriotic outburst that followed the Mars mission has fuelled the latest example of Indian space cinema: Mission Mangal (Sanskrit for Mars), a fictionalised account of the Orbiter Mission. Starring and produced by Bollywood actor Akshay Kumar, it is due for release on 15 August, India’s Independence Day. “I would follow the news about India’s space missions and feel proud of what we were achieving,” says Kumar. “But through Mission Mangal I guess you could say I have an insider’s perspective.”

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Ebola now curable after trials of drugs in DRC, say scientists

Congo results show good survival rates for patients treated quickly with antibodies

Ebola can no longer be called an incurable disease, scientists have said, after two of four drugs being trialled in the major outbreak in the Democratic Republic of the Congo were found to have significantly reduced the death rate.

ZMapp, used during the massive Ebola epidemic in Sierra Leone, Liberia and Guinea, has been dropped along with Remdesivir after two monoclonal antibodies, which block the virus, had substantially more effect, said the World Health Organization and the US National Institute of Allergy and Infectious Diseases, which was a co-sponsor of the trial.

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Giant river animals on verge of extinction, report warns

Populations of great freshwater species, from catfish to stingrays, have plunged by 97% since 1970

Populations of the great beasts that once dominated the world’s rivers and lakes have crashed in the last 50 years, according to the first comprehensive study.

Some freshwater megafauna have already been declared extinct, such as the Yangtze dolphin, and many more are now on the brink, from the Mekong giant catfish and stingray to India’s gharial crocodiles to the European sturgeon. Just three Chinese giant softshell turtles are known to survive and all are male. Across Europe, North Africa and Asia, populations have plunged by 97% since 1970.

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‘War on cancer’ metaphors may do harm, research shows

Use of military terminology can make people more fearful and fatalistic, say psychologists

The ubiquitous use of war metaphors when referring to cancer may do more harm than good, according to research into the psychological impact the phrases have on people’s views of the disease.

Framing cancer in military terms made treatment seem more difficult and left people feeling more fatalistic about the illness, believing there was little they could do to reduce their risk, researchers found.

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Climate crisis may be increasing jet stream turbulence, study finds

Potential impacts of rise in vertical shear include longer, bumpier and dearer flights

The climate crisis could be making transatlantic flights more bumpy, according to research into the impact of global heating on the jet stream.

Jet streams are powerful currents of air at the altitudes which planes fly. . They result from the air temperature gradient between the poles and the tropics, and reach speeds of up to 250mph (400kmph). They also sometimes meander.

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Terrawatch: why salt crystals ‘snow’ down on Dead Sea floor

Scientists have observed up to 10cm of salt falling to sea floor every year since 1979

Try swimming in the Dead Sea and you can’t help but float. This salt lake, bordered by Jordan, Israel and the West Bank, is nearly 10 times as salty as the oceans. In recent decades diversion of freshwater streams has made it even saltier, and since 1979 scientists have observed salt crystals “snowing” down, depositing up to 10cm on the sea floor every year. It’s the only place in the world where this happens and now scientists think they know why.

During summer the Dead Sea separates into two layers: a warm super-salty layer sitting above a cooler less-salty layer. The research, published in Water Resources Research , shows that when small waves break this boundary they encourage salty fingers to penetrate into the lower layer. Warm water holds more salt than cool water, so as the fingers cool they produce salt crystals which then rain down on the sea floor.

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Tardigrades may have survived spacecraft crashing on moon

Scientists believe the Beresheet’s unusual cargo may be alive and well on the moon

The odds of finding life on the moon have suddenly rocketed skywards. But rather than elusive alien moonlings, the beings in question came from Earth and were spilled across the landscape when a spacecraft crashed into the surface.

The Israeli Beresheet probe was meant to be the first private lander to touch down on the moon. And all was going smoothly until mission controllers lost contact in April as the robotic craft made its way down. Beyond all the technology that was lost in the crash, Beresheet had an unusual cargo: a few thousand tiny tardigrades, the toughest animals on Earth.

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