Category Archives: Science

US regulators approve two gene therapies for sickle cell disease

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Blood disorder that can lead to premature death affects estimated 100,000 people in the United States, most of whom are Black

The US Food and Drug Administration has approved a pair of gene therapies for sickle cell disease, including the first treatment based on the breakthrough Crispr gene-editing technology, opening up two “transformative therapy” avenues for some patients.

The FDA approved Lyfgenia from Bluebird Bio, and a separate treatment called Casgevy by partners Vertex Pharmaceuticals and Crispr Therapeutics. Both therapies are made from the patients’ own blood stem cells and were approved for people aged 12 and older.

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Plant fossils turn out to be turtles in ‘unusual misidentification’

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Re-examination finds what were taken to be veins of leaves are actually bone growth patterns

Two small, oval fossils thought to be prehistoric plants are actually the remains of baby marine turtles, researchers have revealed.

The fossils, found in rocks dating to between 132 and 113 million years ago, were discovered in Colombia in the middle of the 20th century by Padre Gustavo Huerta, a priest with a penchant for fossil plants.

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HIV vaccine trial in Africa halted after disappointing initial results

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African-led trial ended a year early as researchers conclude there is ‘little or no chance’ new combination vaccines cut HIV risk

The first trial in Africa of two combination vaccines to prevent HIV has been halted after researchers concluded it was not working.

The vaccines (part of the PrEPVacc study) were being tested on 1,500 people aged between 18 and 40 in Uganda, Tanzania and South Africa.

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Covid inquiry: Johnson surprised ‘eat out to help out’ not cleared by scientists

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Former PM also angrily denies comments he made about letting Covid ‘rip’ meant he had been uncaring

Boris Johnson assumed that Rishi Sunak’s flagship “eat out to help out” hospitality scheme had been cleared by government scientists and was surprised to learn later it was not, the former prime minister has told the inquiry into Covid.

In evidence that could pose notable difficulties for the prime minister when he appears before the inquiry on Monday, Johnson said it would have been “normal” for advisers such as Chris Whitty and Patrick Vallance to have been briefed, and that he assumed this had been the case.

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Boris Johnson says he regrets questioning existence of long Covid and admits No 10 culture could be argumentative – UK politics live

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Former prime minister also admits he should have worked more closely with devolved administrations

Hugo Keith KC is questioning Johnson.

He asks if Johnson’s approach has been to give all relevant material to the inquiry.

I understand the feelings of these victims and their families and I am deeply sorry for the pain and the loss and suffering of those victims and their families.

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Call to help UK IVF patients donate unused embryos after shortage hinders research

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Scientists complain after ‘sheer waste’ of human embryos discarded despite patients’ wishes

Leading scientists are calling for a change in the law to help IVF patients donate unused embryos to biomedical research after a collapse in donations over the past 15 years.

The increasing commercialisation of IVF, overstretched NHS clinics and cumbersome paperwork are blamed for a 25-fold decrease in the number of donated embryos. Scientists described some patients going to “extraordinary lengths” to ensure their embryos could be used for research rather than discarded, with many private clinics failing to routinely offer donation as an option.

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Boris Johnson’s legacy will be shaped by Covid inquiry appearance

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Discredited ex-PM faces a demolition job in one of the few policy areas to which he and his allies still cling

Even at the height of his popularity, Boris Johnson routinely avoided close questioning – to the extent of once hiding in a fridge to dodge a TV inquisitor. The former UK prime minister is likely to be dreading next week’s appearance at the Covid inquiry. And he probably should.

It is no exaggeration to say that events on Wednesday and Thursday at the inquiry’s repurposed office building in Paddington, west London, could help define the post-power image and legacy of Johnson, and very possibly not for the good.

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Astronomers spot ‘overweight’ planet that appears too big for tiny host star

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Fact that planet 13 times bigger than Earth is orbiting star nine times smaller than sun shows ‘how little we know about the universe’

Astronomers have spotted an “overweight” planet that appears to be far too massive for its petite host star.

The planet, which is 13 times bigger than Earth, is orbiting a star called LHS 3154, which is nine times smaller than the sun. The planet’s heft is unremarkable in its own right, but its pairing with an ultracool dwarf star, the smallest and coldest stars in the universe, has puzzled scientists.

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Matt Hancock ‘was not told about eat out to help out scheme until day it was announced’ – as it happened

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This live blog is now closed, you can read more on this story here

Hancock is now deploying the defence previewed in the Observer on Sunday. (See 9.58am.)

He says from the middle of January the DHSC was “trying to effectively raise the alarm”. He says:

We were trying to wake up Whitehall to the scale of the problem and this wasn’t a problem that couldn’t be addressed only from the health department. Non-pharmaceutical interventions cannot be put in place by a health department. A health department can’t shut schools. It should have been grasped and led from the centre of government earlier. And you’ve seen evidence that repeatedly the department and I tried to make this happen.

And we were on occasions blocked, and at other times our concerns were not taken as seriously as they should have been until the very end of February.

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Genetic data on 500,000 volunteers in UK to be released for scientific study

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UK BioBank offers up biggest ever cache of whole-genome sequences for medical research

A new era of medical discoveries, treatments and cures is on the horizon, researchers say, following the announcement that an unprecedented trove of genetic information is to be made available to scientists.

Health researchers from around the world can now apply to study the whole genomes of half a million people enrolled in UK Biobank, a biomedical research project that has compiled detailed health and lifestyle records on individuals since it began 20 years ago.

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UK Biobank and the masses of medical data that became key to genetic research

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The resource, which is on the move to Manchester, now ranks as the world’s most important health database

The origins of the UK Biobank can be traced back to a pilot study in a building in Stockport bordered by the Cheadle Heath police station on one side and the local recreation ground on the other. It was the early 2000s and scientists had realised the potential for genomics and big data to transform health research.

With diabetes, cancer, dementia and other ailments on the rise, scientists pushed for a database devoted to genetics, health and lifestyle to help them tease apart who was most at risk and how diseases could be prevented.

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‘A biodiversity catastrophe’: how the world could look in 2050 – unless we act now

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The climate crisis, invasive species, overexploitation of resources and pollution could break down crucial ecosystems. We asked experts to lay out the risks and offer some solutions

The continued destruction of nature across the planet will result in major shocks to food supplies and safe water, the disappearance of unique species and the loss of landscapes central to human culture and leisure by the middle of this century, experts have warned.

By 2050, if humanity does not follow through on commitments to tackle the five main drivers of nature loss critical natural systems could break down just as the human population is projected to peak.

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‘They thought I had cancer’: painkiller banned in UK linked to Britons’ deaths in Spain

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Patients’ group says reactions to metamizole can cause sepsis and organ failure – and British and Irish people are at higher risk

A patients group representing several British victims has launched legal action against the Spanish government over claims it failed to safeguard people against the potentially fatal side effects of one of the country’s most popular painkillers, involved in a series of serious illnesses and deaths.

The drug metamizole, commonly sold in Spain under the brand name Nolotil, is banned in several countries, including Britain, the US, India and Australia. It can cause a condition known as agranulocytosis, which reduces white blood cells, increasing the risk of potentially fatal infection.

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Bone cows bred in Australia provide base material for dental grafts

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Use of cattle from country free of mad cow disease means product is safe, experts say, and patients can still donate blood

Bone cows, specially bred in mad cow-free Australia, are being used instead of human donors for dental and medical bone grafts.

While bovine grafts have been tested for spinal fusion, foot reconstructions and to fix skull traumas, the Australian versions are predominantly used in dental work to strengthen degraded jaws before tooth implants.

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China supplies data to WHO about clusters of respiratory illness

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Epidemiologists say wave in north, particularly among children, may be partly caused by ‘immunity debt’

Chinese health authorities have provided the requested data on an increase in respiratory illnesses and reported clusters of pneumonia in children, and have not detected any unusual or novel pathogens, the World Health Organization (WHO) said on Thursday.

The WHO had asked China for more information on Wednesday after groups including the Program for Monitoring Emerging Diseases reported clusters of undiagnosed pneumonia in children in north China.

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OpenAI ‘was working on advanced model so powerful it alarmed staff’

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Reports say new model Q* fuelled safety fears, with workers airing their concerns to the board before CEO Sam Altman’s sacking

OpenAI was reportedly working on an advanced system before Sam Altman’s sacking that was so powerful it caused safety concerns among staff at the company.

The artificial intelligence model triggered such alarm with some OpenAI researchers that they wrote to the board of directors before Altman’s dismissal warning it could threaten humanity, Reuters reported.

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Cheap over-the-counter nail drug found to work on crippling flesh-eating disease

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‘Momentous’ breakthrough as trial finds treatment for nail infections to be highly effective for neglected tropical disease

A cheap and easily taken drug used to treat fungal nail infections has been found to work against a devastating flesh and bone-eating disease found across Africa, Asia and the Americas.

Researchers say the breakthrough offers hope to thousands of patients who have suffered decades of neglect and can face amputations if the disease is left untreated.

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Scientists raise hopes of cure for eczema itchiness with study of skin bacteria

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Researchers say they have discovered a common type of bacteria can trigger irritation

Whether it’s a tickle of the nose, or an irritation in one’s hair, itches can be excruciating. Now scientists say they have found a common type of skin bacteria can trigger the sensation.

Crucially, as such bacteria are commonly found on the skin of patients with eczema – or atopic dermatitis – the work helps explain why such conditions can be accompanied by the urge to scratch.

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Chris Whitty says No 10 decision-making ‘chaotic’ under Boris Johnson but other countries were similar – UK Covid inquiry live

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Chief medical officer for England and chief UK medical adviser says civil servants did good job but PM took ‘unique’ decisions

Q: Was there no aspect on the pandemic on which you did not advise?

Whitty says he would not put it like that. He says he felt it important to advise on issues where advice from a scientist or doctor would be useful.

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Boris Johnson ‘bamboozled’ by science and Matt Hancock had habit of saying things that were untrue, UK Covid inquiry hears – live

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Former chief scientific adviser Patrick Vallance revealed there was ‘complete lack of leadership’ at times in crisis

Vallance says that some of what he was doing during Covid would have been done by anyone else in the post of government chief scientific adviser (GCSA).

But he says because of his medical training, and his knowledge of vaccines (he had worked for GlaxoSmithKline before taking the GCSA job), he was probably more involved than another GCSA might have been.

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