Gene-edited sheep offer hope for treatment of lethal childhood disease

Roslin Institute engineered a flock to help research into the genetics of Batten disease

A flock of gene-edited sheep has been used by scientists to pinpoint a promising treatment for a lethal inherited brain disease that afflicts young children. The researchers, based in the UK and US, say their work could lead to the development of drugs to alleviate infantile Batten disease.

In the UK, Batten disease affects between 100 and 150 children and young adults and is inherited from two symptomless parents who each carry a rare recessive gene mutation.

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Challenge to government’s lateral flow test contracts rejected by high court

Health and social care secretary’s decision to grant contracts to UK firm Abingdon Health was the subject of litigation

A legal challenge to the government’s award of multimillion-pound contracts for lateral flow tests that later failed to gain regulatory approval has been rejected by the high court.

The health and social care secretary’s decision to grant three contracts to UK firm Abingdon Health was the subject of litigation by campaigning organisation Good Law Project (GLP), which has brought several cases challenging the way contracts were awarded during the pandemic.

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Health workers among dead in Ugandan Ebola outbreak

MSF calls situation ‘very serious’ as east African country grapples with outbreak of Sudan strain of virus, for which no vaccine exists

It seems like a normal day in Mubende, central Uganda. Shops remain open, children are at school and public gatherings are allowed, provided people remain socially distant.

The ambulances that whisk past every few hours and the health workers who wash themselves meticulously before they return home are the only indications that it is not business as usual in the densely populated mining district, which is struggling to contain an outbreak of Ebola.

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Toxic air pollution particles found in lungs and brains of unborn babies

Particles breathed by mothers pass to their vulnerable foetuses, with potentially lifelong consequences

Toxic air pollution particles have been found in the lungs, livers and brains of unborn babies, long before they have taken their first breath. Researchers said their “groundbreaking” discovery was “very worrying”, as the gestation period of foetuses is the most vulnerable stage of human development.

Thousands of black carbon particles were found in each cubic millimetre of tissue, which were breathed in by the mother during pregnancy and then passed through the bloodstream and placenta to the foetus.

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Drone footage shows orcas chasing and killing great white shark

Scientists say behaviour, filmed in South Africa, has never been seen in detail before – and never from the air

Scientists have published findings confirming that orcas hunt great white sharks, after the marine mammal was captured on camera killing one of the world’s largest sea predators.

A pod of killer whales is seen chasing sharks during an hour-long pursuit off Mossel Bay, a port town in the southern Western Cape province, in helicopter and drone footage that informed a scientific study released this week.

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Wax worm saliva rapidly breaks down plastic bags, scientists discover

Its enzymes degrade polyethylene within hours at room temperature and could ‘revolutionise’ recycling

Enzymes that rapidly break down plastic bags have been discovered in the saliva of wax worms, which are moth larvae that infest beehives.

The enzymes are the first reported to break down polyethylene within hours at room temperature and could lead to cost-effective ways of recycling the plastic.

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People with recent dementia diagnosis found to have higher suicide risk

Calls for more support after England research shows those diagnosed under 65 also at greater risk

People who have recently been diagnosed with dementia, or who are diagnosed with the condition at a younger age, are among those at increased risk of suicide, researchers have found. The findings have prompted calls for greater support for those experiencing such cognitive decline.

While previous research has explored a potential link between dementia diagnosis and suicide risk, the results have been inconclusive, with some suggesting a raised risk and others a reduced risk.

•In the UK and Ireland, Samaritans can be contacted on freephone 116 123, or email jo@samaritans.org or jo@samaritans.ie. In the US, the National Suicide Prevention Lifeline is at 800-273-8255 or chat for support. You can also text HOME to 741741 to connect with a crisis text line counselor. In Australia, the crisis support service Lifeline is 13 11 14. Other international helplines can be found at befrienders.org

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Swedish geneticist wins Nobel prize for Neanderthal research

Svante Pääbo receives 2022 award in physiology or medicine for genome discoveries including Neanderthals

A Swedish geneticist has been awarded the 2022 Nobel prize in physiology or medicine.

Svante Pääbo won the 10m Swedish kronor (£867,000) prize announced on Monday by the Royal Swedish Academy of Sciences in Stockholm.

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‘Unprecedented’ bird flu epidemic sees almost 50m birds culled across Europe

Poultry farmers from Arctic to Portugal reported 2,500 outbreaks in past year, with migrating birds taking avian flu to North America

The UK and continental Europe have been hit by an “unprecedented” number of cases of avian flu this summer, with 47.7m birds having been culled since last autumn, according to new figures.

Poultry producers from as far north as Norway’s Svalbard islands to southern Portugal have together reported almost 2,500 outbreaks of the disease since last year.

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‘Basically a bullseye’: Nasa crashes spacecraft into asteroid to test Earth’s defenses – as it happened

Space agency conducts Dart mission to learn whether asteroid’s trajectory can be diverted away from Earth

Six minutes to impact on what is one of Nasa’s coolest missions of recent history.

It has taken Dart 10 months and 470m miles to get here, since launch last year.

Usually Nasa spacecraft are intended to operate for many years, or even decades, but not Dart.

Dart was built to be destroyed. Dart is a mission of firsts, proving that a spacecraft can autonomously seek, find and approach a target in space that’s so far away we don’t even know what it looks like.

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Nasa successfully crashes spacecraft into asteroid in planetary defense test

Bid to change asteroid’s course marks ‘new era of humankind’ as agency seeks to protect Earth from future disaster

A multimillion-dollar spacecraft collided head-on with an asteroid the size of a football stadium on Monday in an unprecedented test of Nasa’s capacity to defend Earth from a doomsday scenario.

Nasa’s craft successfully crashed into the asteroid Dimorphos 6.8m miles from Earth. The mission, known as Dart (Double Asteroid Redirection Test), marked humanity’s first attempt at moving another celestial body, with the goal of seeing if a large asteroid hurtling toward our planet could be successfully diverted.

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Water found in asteroid dust may offer clues to origins of life on Earth

Discovery offers new support for the theory that life may have been seeded from outer space

Specks of dust that a Japanese space probe retrieved from an asteroid about 186 million miles (300m kilometres) from Earth have revealed a surprising component: a drop of water.

The discovery offers new support for the theory that life on Earth may have been seeded from outer space.

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‘Father of quantum computing’ wins $3m physics prize

David Deutsch, who proposed an as yet unbuildable machine to test existence of parallel universes, shares prize with three others

A theoretical physicist who has never had a regular job has won the most lucrative prize in science for his pioneering contributions to the mind-bending field of quantum computing.

David Deutsch, who is affiliated with the University of Oxford, shares the $3m (about £2.65m) Breakthrough prize in fundamental physics with three other researchers who laid the foundations for the broader discipline of quantum information.

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‘Alien goldfish’ may have been unique mollusc, say scientists

Researchers think they may have solved enduring mystery of where Typhloesus wellsi sits on tree of life

The mystery of a bizarre creature dubbed the “alien goldfish”, which has baffled fossil experts for decades, may have been solved, according to scientists who say the animal appears to have been some sort of mollusc.

Typhloesus wellsi lived about 330m years ago and was discovered in the Bear Gulch Limestone fossil site in Montana in the late 1960s, with the remains of other species subsequently identified.

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Israeli archaeologists find traces of opium in 3,500-year-old pottery

Archaeologists say find supports theory that drug was used in burial rituals, possibly to ‘enter ecstatic state’

Israeli archaeologists have discovered opium residue in 3,500-year-old pottery pieces, providing evidence to support the theory that the hallucinogenic drug was used in ancient burial rituals.

The joint investigation by the Israel Antiquities Authority and Weizmann Institute of Science began in 2012 when excavations in the central Israeli town of Yehud revealed a series of late bronze-age graves.

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Moves as smooth as silk: scientists uncover Australian ant-slayer spider’s hunting secrets

With stealth followed by speedy acrobatics, Euryopis umbilicata can successfully catch banded sugar ants twice its size

A mid-air cartwheel, the judicious use of sticky silk and a quick rappel down a tree, all in the blink of an eye: researchers have identified how the Australian ant-slayer spider captures prey twice its size.

The acrobatic behaviour of the Australian ant-slayer spider, Euryopis umbilicata, as it hunts and eats banded sugar ants has been documented by scientists for the first time.

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Monkeypox: don’t touch foreigners, says China health chief, as first case reported

Official Wu Zunyou also called for people to avoid ‘skin-to-skin contact’ with those who had been abroad recently, as well as ‘strangers’

A senior Chinese health official has advised people to avoid physical contact with foreigners to prevent possible monkeypox infection after the first known case of the virus on mainland China was reported on Friday.

“To prevent possible monkeypox infection and as part of our healthy lifestyle, it is recommended that 1) you do not have direct skin-to-skin contact with foreigners,” Wu Zunyou, chief epidemiologist at the China Centers for Disease Control and Prevention posted on his official Weibo page on Saturday.

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Fireball seen over UK confirmed as meteor after day of confusion

Experts revise initial assumption that sighting was space junk linked to Elon Musk’s satellite programme

A fireball seen over many parts of the northern UK has been confirmed as a meteor after a day of confusion about its identity.

The fireball was visible above northern England, Northern Ireland and Scotland as it blazed across the clear night sky just after 10pm on Wednesday night.

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Obesity-related cancer rates nearly quadruple in Australia over three and a half decades

Researchers call on governments to implement national obesity strategy to help stem further rises in preventable cancers

The rate of obesity-related cancers in Australia has almost quadrupled in a few generations, new research suggests.

Researchers at the Daffodil Centre, a joint venture of Cancer Council New South Wales and the University of Sydney, analysed the rate of 10 obesity-linked cancers between 1983 and 2017.

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‘We’ve experienced an anomaly’: Bezos’s latest Blue Origin launch fails

New Shepard rocket fails shortly after launch, but uncrewed capsule jettisons successfully

An uncrewed rocket belonging to Jeff Bezos’s space company, Blue Origin, failed shortly after launch in Texas on Monday morning, a potential setback for the Amazon founder’s wider ambitions of sending humans into orbit.

The malfunction of the New Shepard booster, a type of rocket that is similar to the one Blue Origin has used this year to send three crews of up to six people on suborbital flights, came 1min 4sec after launch and just as the vehicle was reaching its maximum dynamic pressure, known as “max q”.

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