UK passes 10m Covid vaccination milestone

About 15% of population has been offered first jab, as experts call for focus on hotspots

Britain has given a first dose of a coronavirus vaccine to more than 10 million people, as public health experts call on ministers to target future vaccinations in hotspots where the disease is threatening to run out of control.

Official figures from across the UK’s four nations showed that 374,756 people received a jab on Tuesday, taking the headline total to 10.02 million, less than two months after the programme began.

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Israel opens coronavirus vaccines to all over-16s

New age group eligible from Thursday while focus remains on older at-risk people

Israel’s health ministry has said it will offer coronavirus vaccines to anyone over the age of 16, as part of a rapid campaign in which the majority of older and vulnerable people have already received shots.

The ministry has told healthcare providers they can start booking appointments for the new age group starting on Thursday.

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Up in flames: SpaceX Starship test flight ends in fiery crash, again

  • Futuristic rocket explodes on landing after test in Texas
  • Elon Musk developing Starship to carry people to Mars

SpaceX’s second full test flight of its futuristic, bullet-shaped Starship ended in another fiery crash landing on Tuesday.

Elon Musk’s company launched its latest Starship prototype from the south-eastern tip of Texas, two months after the previous test ended in an equally explosive belly flop.

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Sputnik V vaccine has 91.6% efficacy against symptomatic Covid, Russian trial suggests

Preliminary findings based on analysis of data from more than 20,000 participants

The Sputnik V vaccine, which has been the subject of scepticism since Russia began using it last year before trials had ended, is 91.6% effective against symptomatic Covid according to data published in one of the world’s leading medical journals.

Results in the Lancet from 20,000 trial participants suggest Sputnik’s efficacy is on a par with that of some of the leading vaccines now in use. There was good efficacy in older adults, who are at highest risk for death, but little diversity, since most participants were white males.

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Even with vaccines, we still need treatments for Covid. So what works?

Analysis: death rates in intensive care are falling as doctors identify more ways to help those with the disease

Vaccines may have been described as the great escape route from the Covid pandemic – but treatments, which are bringing down death rates, will be needed as much as ever in the era of jabs because the virus is not expected to go away in the foreseeable future, experts say.

“It’s going to take a long time to vaccinate the world,” said Peter Horby of Oxford University, chief investigator of the Recovery trial into Covid treatments and chair of the New and Emerging Respiratory Virus Threats Advisory Group (Nervtag). “I don’t know what the estimates are, but we’ve already seen issues with manufacturing scale-up and difficulties in delivering at scale.

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High infection rate makes effort to contain Covid variants even more vital

Analysis: scramble to stop spread of South African variant makes sense but may already be too late

When the coronavirus pandemic was in its infancy, one of the common silver linings scientists mentioned was the virus’s slow rate of mutation. It raised the hope that the virus lacked the agility to rapidly evolve around human immunity – whether from previous infection or vaccine. The virus is certainly slow to mutate by some standards. Sars-CoV-2 typically acquires two single letter changes in its genetic code a month, about half the rate seen in influenza.

So why are so many new variants emerging? At the heart of the problem is the fact the global pandemic is raging. Every new case is a chance for mutations to arise, spread and build up. In the simple arithmetic of evolution, when a virus mutates and gains an advantage it can rise above the others.

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Covid mortality down dramatically since start of pandemic

New research shows global death rates among patients in intensive care have fallen from 60% to 36%

Death rates among people who end up in intensive care with Covid-19 have improved dramatically since the start of the pandemic thanks to advances in treatment, new research has found.

The proportion of those worst affected by the disease who die from it has fallen from 60% when it first appeared early last year to 36% by October, the study of global trends shows.

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Tokyo Olympics: definitely going ahead unless cancelled again?

Billed as a celebration of humankind’s victory over coronavirus, Games could fall foul of pandemic for a second time

The Olympic rings have been spruced up and are once again overlooking Tokyo Bay. Countdown clocks have been reset, telling passersby there are just 171 days to go until the Tokyo 2020 Olympic Games begin.

They are supposed to build excitement in the host city and among sports fans around the world. But Japan’s Olympic dream is quickly turning sour in the face of the worst global health crisis for a century.

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What we know about the South African variant of Covid

Experts say 501Y.V2 variant is more infectious and resistant to vaccines, though there are no signs that it leads to more severe disease

The South African variant, like the new UK variant, contains a mutation known as N501Y which is believed to make the virus more contagious than older variants. The South African variant also contains other mutations of concern, including E484K and K417N. These two mutations are thought to explain why the South African variant appears to be better able to evade neutralising antibody responses by the body.

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Is it possible to change a chicken’s sex before it hatches?

Billions of unwanted male chicks are slaughtered by the farming industry. Now a startup claims to have found a surprising solution to the problem

The eggs we eat have a hidden cost. About 7bn male chicks are killed worldwide every year to produce them. Farmers need to replenish their supply of egg-laying hens but, by nature, half the chicks that hatch are male and growing them for meat is uneconomic – that industry uses faster growing breeds. In many countries they are tossed into shredding machines, although in the UK they are gassed.

But what if those male chicks could instead hatch out as functional females, able to grow into egg-laying birds? That’s the vision of Israeli startup Soos Technology. Founded in 2017, the company, which has received $3.3m in investment and prize winnings, wants to make commercial hatcheries kinder and more economic by changing the effective sex of poultry embryos as they develop.

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I’m an NHS consultant anaesthetist. I see the terror in my Covid patients’ eyes

As a hospital consultant working in intensive care, the reality of coronavirus and patients’ fear is brought home to me every day

I’m not ready,” the patient implores me through her CPAP [continuous positive airway pressure] hood. She’s breathing at more than triple her normal rate and I’ve been asked to intubate her as she’s deteriorating, despite three days in intensive care. She is 42 years old.

There’s terror in her eyes. A tear runs down her cheek. She’s looking at the patient opposite who is in an induced coma, intubated and ventilated, and isn’t doing well.

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Professor Avi Loeb: ‘It would be arrogant to think we’re alone in the universe’

When Harvard professor Avi Loeb discovered possible signs of extraterrestrial activity, it caused a scandal in the research community. Is fear and conservatism stopping science from considering plausible evidence that there are aliens out there?

By the time humanity noticed the object, it was already leaving the solar system. 19 October 2017. Astronomers at the University of Hawaii notice an odd shape tumbling away from Earth, a bright speck hurtling through the deep dark. Informally, they name it ‘Oumuamua, from the Hawaiian for “scout”, and classify it an interstellar asteroid, the first known to visit our solar system. Really, nobody could be sure what it was. Asteroids are rocky and dull and commonly round, but ‘Oumuamua was shiny and elongated. Astronomers had first thought it a comet, but comets have bright gassy tails, and here there wasn’t one. The more data was collected, the more mysterious the object seemed. “Time after time it looked unusual,” says the astrophysicist Avi Loeb, over Zoom. “At some point it crossed a threshold for me. And at that point you say, ‘OK, come on!’”

Loeb is the Frank B Baird Jr Professor of Science at Harvard and, until recently, the longest-serving chair of Harvard’s department of astronomy. When we speak, he is in his home office – big old fireplace, books about the cosmos, a remarkable quantity of dark wood – preparing to discuss his new book, Extraterrestrial, in which he argues an exotic hypothesis: that ‘Oumuamua was “designed, built and launched by an extraterrestrial intelligence”. Loeb is 59, but energised like a child. “I should tell you,” he warns, gently teasing, a few days after the US Capitol is stormed. “Today I’m supposed to be interviewed by Fox News. Some people said, ‘Avi, don’t do it. How could you do that?’ And I said, ‘Look, science doesn’t have a political agenda – we should speak to everyone!’”

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In the search for Covid protection, Cormac the ‘extremely charismatic’ llama may hold a key

The llama has provided nanobodies that effectively prevent infection, but the use of other species in Covid research raises troubling ethical questions

Cormac the llama lives a quiet life on a farm in Washington State, totally unaware that his unique immune system may be key to protecting the developing world from Covid-19.

“He is an extremely charismatic llama … he’s a pretty cool guy,” says TJ Esparza, a neuroscientist at the Uniformed Services University. He is part of the team attempting to transform Cormac’s nanobody cells into a drug that will coat the inside of human lungs, providing temporary but effective protection from coronavirus particles.

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‘Find of the century’: medieval hoard of treasures unearthed in Cambridge

Graves found under demolished student halls are providing valuable insight into life in a post-Roman settlement

An early medieval graveyard unearthed beneath student accommodation at Cambridge University has been described as “one of the most exciting finds of Anglo-Saxon archaeology since the 19th century”.

King’s College discovered the “extensive” cemetery, containing more than 60 graves, after demolishing a group of 1930s buildings which had recently housed graduates and staff in the west of the city, to make way for more modern halls.

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‘I wanted to give something back’: the academic who signed up for the Novavax trial

Librarian says she feels ‘very lucky’ working from home, so she volunteered for the vaccine test

While many have endured almost a year of stress and hardship during the Covid crisis in the UK, others have remained relatively unscathed.

Caroline Ball, a 37-year-old academic librarian from just outside Derby, has even felt guilty at times, having the good fortune of a stable job which she can do from home and not worrying about homeschooling children.

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Coronavirus live news: Coachella festival cancelled; fears over Australian vaccine

Shock and anger at EU’s move to invoke Brexit clause on Irish border; Fauci says ‘virus will continue to mutate’ as Democrats aim to fast-track Covid relief plan; Johnson & Johnson one-dose Covid vaccine shown to work

Hello everyone, I’m Molly Blackall, taking over the blog in London. I’ll be bringing you all the key updates in the coronavirus pandemic around the world over the next few hours.

If you spot something you think we should be reporting on in this blog, please feel free to drop me a message on Twitter. Tips and pointers always much appreciated!

The former Northern Ireland secretary Julian Smith has weighed into the row over the EU’s threat to override part of Northern Ireland Protocol under its coronavirus vaccine controls, calling it “almost Trumpian.”

The Tory MP told BBC Radio 4’s Today programme: “Years have been spent trying to ensure goods will flow freely and there will be no hard border and last night the EU pulled the emergency cord without following any of the process that are in the protocol if one side wants to suspend it.

And they did that, in my view, without anywhere near the understanding of the Good Friday Agreement, of the sensitivity of the situation in Northern Ireland, and it was an almost Trumpian act.

It is not just a backdoor for goods going to Britain, it is a very sensitive place and we have a duty of care between the EU and the UK to preserve no hard border and stability in Northern Ireland.

Related: EU in U-turn over move to control vaccine exports to Northern Ireland

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Everyday Covid mistakes we are all still making

Can we do more as individuals to help slow the spread of coronavirus? We ask the experts

Covid-19 infections in the UK are reducing but remain stubbornly high, despite a month of lockdown measures. So could we be doing more as individuals to curb transmission of the virus? A virologist, a psychologist and a public health expert share their views on some of the Covid-19 mistakes that we are all still making.

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Will Covid-19 sniffing dogs allow fans back into sporting events?

The Miami Heat will employ canines to sniff out the virus among fans attending games. But can dogs be trained in time to work at the Super Bowl?

Nearly 100 million people are expected to watch Super Bowl LV in Tampa, the first time the big game has been held during a pandemic (the World Series has survived two). But only 22,000 of those viewers, 7,500 of them vaccinated healthcare workers, will be in actual attendance, representing just one-third the capacity of Raymond James Stadium. Social distancing and face-coverings will be enforced. The first few rows will be kept clear as a buffer between the field and the fans. By this stage of the pandemic, everyone should be aware that, at any one time, a portion of the population is composed of asymptomatic carriers who can infect others they come into contact with. As a result, any large gathering has the potential to become a super-spreader event with wide-reaching consequences. Large-scale testing at gatherings such as sporting events is limited by the availability of trained personnel, equipment, money, and the time it takes for the results of the actual test to work.

But an unconventional solution may be in the works.

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How effective is the Novavax Covid vaccine and will it work against variants?

Everything you need to know about the trial results for a new coronavirus vaccine

In an interim analysis of a phase 3 clinical trial conducted in the UK, the vaccine has shown 89% efficacy, with 27% of participants in the trial – almost 4,000 people – older than 65. That trial suggested 95.6% efficacy against the original coronavirus and 85.6% efficacy against the more recent UK strain. Those results were based on the first 62 cases of Covid-19 identified among volunteers, with 56 cases among those given a placebo against just six in those given the vaccine.

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