Invasive mosquito could disrupt Africa’s ‘landscape of malaria’ after cases rise

Insecticide-resistant newcomer caused unprecedented urban outbreak in Ethiopia and can survive the dry season, scientists say

Scientists are warning that the invasion of an insecticide-resistant mosquito could change Africa’s “landscape of malaria” after research showed it caused an unprecedented urban outbreak in Ethiopia.

An investigation into a steep rise in cases in the Ethiopian city of Dire Dawa during a dry season this year identified the mosquito as the cause of the outbreak. Scientists say it is the strongest evidence to date that it could prompt surges of malaria in areas typically less affected by the disease.

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Malaria vaccine a step closer as experts urge Truss not to ‘turn off the tap’ on funding

Chance to eradicate diseases such as malaria could be lost and UK innovation squandered if global health investment is cut, jab co-creator tells PM

The co-inventor of a groundbreaking vaccine that could eradicate malaria has implored Liz Truss not to squander cutting-edge UK innovation by “turning off the taps” on global health funding.

Speaking as successful results from the latest trials of the R21 vaccine were revealed, Prof Adrian Hill, director of Oxford University’s Jenner Institute, said it would be tragic if Britain cut funding just as scientists were poised to make “a real impact” against malaria.

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Increase funding or abandon hope of ending malaria, TB and Aids, UK warned

Global Fund urges UK and other donors to pledge billions to get efforts to end diseases by 2030 ‘back on track’ after catastrophic impact of Covid

Britain is being urged to pledge billions of dollars to get the fight against malaria, tuberculosis and Aids “back on track” after efforts were ravaged by the Covid-19 pandemic.

The UK has historically been one of the main donors to the Global Fund, an international financing organisation aimed at ending the three deadly epidemics by 2030. Now it is warning that, unless donors make an unprecedented total funding pledge of $18bn (£13.25bn) this year, that goal will be missed.

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Malaria kills 180,000 more people annually than previously thought, says WHO

UN agency says world must support urgent rollout of new vaccine as it reveals new figures for malaria deaths

The World Health Organization has called for a “massive, urgent” effort to get the new malaria vaccine into the arms of African children, as it warned that about 180,000 more people were dying annually from the disease than had previously been thought.

Dr Pedro Alonso, director of the WHO’s global malaria programme, said the RTS,S vaccine, recommended for widespread rollout in October, represented a historic opportunity to save tens of thousands of lives, mostly those of under-fives in sub-Saharan Africa.

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The world finally has a malaria vaccine. Now it must invest in it | Ngozi Okonjo-Iweala

As an economist I know it makes financial as well as ethical sense to get this world-first vaccine to the millions who need it

I vividly remember the day I learned a harsh lesson in the tragic burden of malaria that too many of us from the African continent have endured. I was 15, living amid the chaos of Nigeria’s Biafran war, when my three-year-old sister fell sick. Her body burning with fever, I tied her on my back and carried her to a medical clinic, a six-mile trek from my home.

We arrived at the clinic to find a huge crowd trying to break through locked doors. I knew my sister’s condition could not wait. I dropped to the ground and crawled between legs, my sister propped listlessly on my back, until I reached an open window and climbed through. By the time I was inside, my sister was barely moving. The doctor worked rapidly, injecting antimalarial drugs and infusing her with fluids to rehydrate her body. In a few hours, she started to revive. If we had waited any longer, my sister might not have survived.

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Nigeria unlikely to reach ‘impossible’ 40% Covid vaccine target

Lack of doses and a reluctant public make government programme unfeasible, say health experts, with malaria and conflict posing greater risk to life

It will be “impossible” for Nigeria to meet its target of vaccinating 40% of its population by the end of the year because Covid is not being taken seriously, health experts have warned.

Fewer than 1.5% of the country’s 206 million population has been fully vaccinated. But with more people killed in conflict last year and substantially more recorded deaths from malaria than Covid in Nigeria, experts believe it is further down the list of concerns for many in the country.

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Flu, cancer, HIV: after Covid success, what next for mRNA vaccines?

The technology was viewed with scepticism before the pandemic but there is now growing confidence about its use

It is one of the most remarkable success stories of the pandemic: the unproven technology that delivered the Moderna and Pfizer/BioNTech vaccines in record time, helping to turn the tide on Covid-19. The vaccines are based on mRNA, the molecule that instructs our cells to make specific proteins. By injecting synthetic mRNA, our cells are turned into on-demand vaccine factories, pumping out any protein we want our immune system to learn to recognise and destroy.

Pre-pandemic, the technology was viewed with scepticism – a clever concept, but not guaranteed to deliver. Now there is growing confidence that mRNA vaccines could have far-reaching applications in tackling diseases from flu to malaria.

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How biodiversity loss is jeopardising the drugs of the future

From willow bark to mosquitoes, nature has been a source of vital medications for centuries. But species die-off caused by human activity is putting this at risk

What will biodiversity loss mean for drug discovery?
Traditionally used as a painkiller for headaches, snowdrops are now known to slow the onset of dementia. In the 1950s, a natural alkaloid called galantamine was extracted from the bulbs. Today, a synthesised version of this is used to treat Alzheimer’s disease and scientists are investigating further to see if snowdrops might also be effective in the treatment of HIV.

However, over-harvesting has resulted in many snowdrop species becoming threatened. The snowdrop isn’t alone – plants are an abundant source of potential new medicines, often providing us with chemical templates for the design of novel drugs. Yet scientists across the globe say unsustainable use of wild medicinal plants is contributing to biodiversity loss and could limit opportunities to source medicines from nature in the future.

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WHO endorses use of world’s first malaria vaccine in Africa

World Health Organization’s director general hails ‘historic day’ in fight against parasitic disease

The World Health Organization has recommended the widespread rollout of the first malaria vaccine, in a move experts hope could save tens of thousands of children’s lives each year across Africa.

Hailing “an historic day”, the WHO’s director general, Dr Tedros Adhanom Ghebreyesus, said that after a successful pilot programme in three African countries the RTS,S vaccine should be made available more widely.

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Malaria trial shows ‘striking’ 70% reduction in severe illness in children

A study in Burkina Faso and Mali suggests combining anti-malarial drugs and vaccination could reduce deaths and hospitalisations

A trial combining vaccinations and prevention drugs has substantially lowered the number of children dying of malaria in two African countries, according to researchers.

The results of the study, published in the New England Journal of Medicine, have been hailed as “very striking”, especially at a time when decades-long progress on combating malaria has stalled in some countries.

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Genetic engineering test with mosquitoes ‘may be game changer’ in eliminating malaria

UK scientist says gene-drive study rendering female insects infertile may lead to ‘self destruct mosquito’ field tests within 10 years

Scientists have successfully wiped out a population of malaria-transmitting mosquitoes by using a radical form of genetic engineering to render the females infertile – in the most advanced and largest ever test of use of the technology to fight the disease.

As well as bringing fresh hope in the fight against one of the world’s biggest killers, the study lays the foundations for further trials of gene-drive technology, which could mean self-destroying mosquitoes being released into the wild within 10 years.

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Climate crisis ‘may put 8bn at risk of malaria and dengue’

Reducing global heating could save millions of people from mosquito-borne diseases, study finds

More than 8 billion people could be at risk of malaria and dengue fever by 2080 if greenhouse gas emissions continue to rise unabated, a new study says.

Malaria and dengue fever will spread to reach billions of people, according to new projections.

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Oxford Malaria vaccine proves highly effective in Burkina Faso trial

Vaccine developed by scientists at Jenner Institute, Oxford, shows up to 77% efficacy in trial over 12 months

A vaccine against malaria has been shown to be highly effective in trials in Africa, holding out the real possibility of slashing the death toll of a disease that kills 400,000 mostly small children every year.

The vaccine, developed by scientists at the Jenner Institute of Oxford University, showed up to 77% efficacy in a trial of 450 children in Burkina Faso over 12 months.

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Scientists sound warning note over malaria drug resistance in Africa

Rwanda study raises fears erosion of efficacy may have begun, with children at greatest risk

Resistance to malaria drugs in Africa may be starting to take hold, according to a study that maps changes similar to those seen a decade ago when drug resistance spread in south-east Asia.

In Cambodia and neighbouring countries, the artemisinin drug compounds widely used against malaria are no longer always effective. The falciparum malaria parasites have developed genetic mutations that allow them to evade the drugs. There has been great concern that drug resistance could spread to Africa, which has the highest burden of cases of this type of malaria – and the highest toll of child deaths from it.

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Team behind Oxford Covid jab start final stage of malaria vaccine trials

Vaccine could be in use by 2024 if next year’s human trials are successful

The Oxford team that has produced a successful coronavirus vaccine is about to enter the final stage of human trials in its quest for an inoculation against malaria.

The Jenner Institute director, Prof Adrian Hill, said the malaria vaccine would be tested on 4,800 children in Africa next year after early trials yielded promising results.

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Sudan government denies Rift Valley fever outbreak despite reports of deaths

Doctors say cases and dozens of deaths from the disease have occurred since August floods, with cases of malaria and cholera also on the rise

An outbreak of Rift Valley fever has killed dozens of people and infected more than 1,000 in Sudan’s Northern state, according to local doctors.

Doctors told the Guardian the disease has spread across the towns of Merowe, Al Dabbah and Karima, mainly among cattle herders.

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Malaria campaigns fight off Covid disruptions to deliver programmes

Almost all planned work against the disease has gone ahead this year, delivering nets, drugs and the world’s first malaria vaccine

More than 90% of anti-malaria campaigns planned this year across four continents are on track, despite disruptions caused by the coronavirus pandemic, according to new research.

The delivery of insecticide-treated nets and provision of antimalarial medicines in the majority of malaria-affected countries across Africa, Asia and the Americas were still going ahead, a high-level meeting organised by the RBM Partnership to End Malaria heard on Thursday.

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Pandemic could ‘turn back the clock’ 20 years on malaria deaths, warns WHO

Deaths in sub-Saharan African countries could double to more than 700,000 this year if Covid-19 crisis disrupts programmes

Deaths from malaria could double across sub-Saharan Africa this year if work to prevent the disease is disrupted by Covid-19, the World Health Organization has warned.

The UN’s global health agency said that if countries failed to maintain delivery of insecticide-treated nets and access to antimalarial medicines, up to 769,000 people could die of malaria this year. That figure, which would be more than double the number of deaths in 2018, would mark a return to mortality levels last seen 20 years ago.

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‘Millions hang by a thread’: extreme global hunger compounded by Covid-19

Coronavirus ‘potentially catastrophic’ for nations already suffering food insecurity caused by famine, migration and unemployment

The warning from the World Food Programme (WFP) that an extra 265 million people could be pushed into acute food insecurity by Covid-19, almost doubling last year’s total, is based on a complex combination of factors.

WFP’s latest warning underlines the increasing concern among experts in the field that for many the biggest impact will not be the disease, but the hunger hanging off its coat tails.

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