Category Archives: Biology

UK Biobank and the masses of medical data that became key to genetic research

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The resource, which is on the move to Manchester, now ranks as the world’s most important health database

The origins of the UK Biobank can be traced back to a pilot study in a building in Stockport bordered by the Cheadle Heath police station on one side and the local recreation ground on the other. It was the early 2000s and scientists had realised the potential for genomics and big data to transform health research.

With diabetes, cancer, dementia and other ailments on the rise, scientists pushed for a database devoted to genetics, health and lifestyle to help them tease apart who was most at risk and how diseases could be prevented.

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Over the counter genetic tests in UK ‘fail to identify 89%’ of those at serious risk

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Study by University College London also says 5% of users are wrongly told they will develop major illness

Over the counter genetic tests in the UK that assess the risk of cancer or heart problems fail to identify 89% of those in danger of getting killer diseases, a new study has found.

Polygenic risk scores are so unreliable that they also wrongly tell one in 20 people who receive them they will develop a major illness, even though they do not go on to do so.

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‘Extremely rare’ Jurassic-era fossils discovered in Lake Powell

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Tritylodonts, mid-sized mammal-related herbivores, roamed the area’s deserts 200m years ago

Scientists have discovered an “extremely rare” set of fossils at Lake Powell that the National Park Service (NPS) is calling one of the most important vertebrate discoveries in the US this year.

The findings, revealed this week, include skulls and teeth from dozens of mid-sized, mammal-related herbivores called tritylodonts that once roamed the region’s vast desert. The bones lay hidden in the sandstone walls of the reservoir for roughly 180m years before a lucky discovery in March.

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Psychologists investigate meerkats’ response to human emotions

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Researchers explore whether the animals adapt their behaviour in response to people’s happiness, sadness or anger

They are known for living in packs and being sociable animals. Now meerkats are being investigated to see if they can also pick up on human emotions.

Researchers and psychologists from Nottingham Trent University are studying meerkats in zoos to see if they can detect emotions such as happiness, sadness or anger from people, and whether they then adapt their behaviour accordingly.

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Seven new ‘walking leaf’ insect species discovered

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Researchers used genetic analysis to identify species that cannot be distinguished by appearance alone

Seven new leaf insect species, known as “walking leaves”, have been discovered.

The insects exhibit a sophisticated “twigs and leaf-like” camouflage allowing them to blend into their surroundings without detection, posing a challenge to both predators and researchers.

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Nose-picking healthcare workers more likely to catch Covid, data suggests

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Rhinotillexis may be underestimated cause of transmission between staff, say researchers

Nose-picking should be given greater consideration as a potential health hazard, researchers have said, after finding healthcare workers who engaged in rhinotillexis were more likely to catch Covid than those who refrained.

Scientists in the Netherlands say research has previously found healthcare workers who had direct contact with Covid patients were more likely to catch Covid than those who did not.

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Newly discovered whale species could have been heaviest animal ever

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Fossils found in Peru from extinct species show it may have had body mass of 85-340 tonnes – heavier than blue whales

The fossilised bones of an ancient creature that patrolled coastal waters 40m years ago belong to a newly discovered species that is a contender for the heaviest animal ever to have existed on Earth.

Fossil hunters discovered remnants of the enormous and long-extinct whale in a rock formation in the Ica desert of southern Peru. Fully grown adults might have weighed hundreds of tonnes, researchers believe.

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‘Not always king’: fossil shows mammal sinking teeth into dinosaur

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Discovery in China challenges view of early mammals as ‘fodder’ for dinosaurs, say researchers

Whether they had sharp teeth, vicious claws or were simply enormous, dinosaurs were creatures to be feared. But a newly identified fossil shows that, at least sometimes, the underdog bit back.

Experts revealed the 125m-year-old fossil that froze in time after being taken on by a small mammal a third of its size. They are tangled together, the mammal’s teeth sunk into the beaked dinosaur’s ribs, its left paw clasping the beast’s lower jaw.

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Model embryo with heartbeat replicates cells in early pregnancy

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Exclusive: Scientists used stem cells to create the structures, which were unable to develop into a foetus

Scientists have created a model human embryo with a heartbeat and traces of blood in an advance that offers an extraordinary window into the first weeks of life.

The synthetic structure, created from human stem cells without the need for eggs, sperm or fertilisation, replicated some of the cells and structures that would typically appear in the third and fourth week of pregnancy. But it was specifically designed to lack the tissues that go on to form the placenta and yolk sac in a natural embryo, meaning that it did not have the theoretical potential of developing into a foetus.

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Newly released Chinese Covid data points to infected animals in Wuhan

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Previously unseen genomic samples suggest animals at Huanan market were potential source

Newly released data from early in the Covid-19 pandemic has offered a crucial insight into the outbreak’s origins, suggesting that Covid-infected animals were present at a market in Wuhan and could have been a “potential source of human infections”.

A pre-print report on Monday by a team of international researchers fleshed out analysis of previously unseen genomic samples collected by Chinese scientists at the Huanan market in Wuhan in the early days of the pandemic.

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New data links Covid-19’s origins to raccoon dogs at Wuhan market

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Analysis of gene sequences by international team finds Covid-positive samples rich in raccoon dog DNA

Newly released genetic data gathered from a live food market in Wuhan has linked Covid-19 with raccoon dogs, adding weight to the theory that infected animals sold at the site started the coronavirus pandemic, researchers involved in the work say.

Swabs collected from stalls at the Huanan seafood market in the two months after it was shut down on 1 January 2020 were previously found to contain both Covid and human DNA. When the findings were published last year, Chinese researchers stated that the samples contained no animal DNA.

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Parasitic fungus that infects and kills spiders discovered in Brazil

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Exclusive: rare purple organism preys on trapdoor spider in behaviour reminiscent of its ‘zombie’ relatives that feature in apocalyptic TV show The Last of Us

Scientists believe they have discovered a new parasitic fungus which preys on trapdoor spiders in Brazil’s Atlantic rainforest.

The rare organism, which is purple, belongs to a group of fungi that infect invertebrates and take over the host. A closeup image shows the fungus wrapped around the body of a trapdoor spider, poking out of the burrow from which the arachnid grabs insects.

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New analysis of ancient human protein could unlock secrets of evolution

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The technique – known as proteomics – could bring new insights into the past two million years of humanity’s history

Tiny traces of protein lingering in the bones and teeth of ancient humans could soon transform scientists’ efforts to unravel the secrets of the evolution of our species.

Researchers believe a new technique – known as proteomics – could allow them to identify the proteins from which our predecessors’ bodies were constructed and bring new insights into the past 2 million years of humanity’s history.

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Scientist convicted of editing babies’ genes has Hong Kong visa revoked over ‘false statement’

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Local media report inquiry launched over application by Chinese scientist He Jiankui, whose work sparked ethics storm

Hong Kong has reportedly revoked a visa for the controversial gene therapy scientist He Jiankui less than a day after it was revealed he’d been granted one, despite having a criminal record in China for illegal medical practices.

Hong Kong immigration officials said his visa was rescinded and a criminal investigation launched into allegations He had lied on his application form, the South China Morning Post reported.

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Scientist who edited babies’ genes says he acted ‘too quickly’

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Exclusive: He Jiankui stops short of apologising for procedure that shocked the world of science in 2018

The scientist at the heart of the scandal involving the world’s first gene-edited babies has said he moved “too quickly” by pressing ahead with the procedure.

He Jiankui sent shock waves across the world of science when he announced in 2018 that he had edited the genes of twin girls, Lulu and Nana, before birth. He was subsequently sacked by his university in Shenzhen, received a three-year prison sentence, and was broadly condemned for having gone ahead with the risky, ethically contentious and medically unjustified procedure with inadequate consent from the families involved.

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Plant toxin hailed as ‘new weapon’ in antibiotic war against bacteria

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Scientists say albicidin has allowed them to take a giant step forward to creating a powerful new range of antibacterial drugs

Scientists have discovered a plant toxin whose unique method of dispatching bacteria could be used to create a powerful new range of antibiotics. The prospect of developing new antibacterial drugs this way has been hailed by doctors, who have been warning for many years that the steady rise of multidrug-resistant pathogens such as E coli now presents a dangerous threat to healthcare across the planet.

The new antibiotic – albicidin – attacks bacteria in a completely different way to existing drugs, a group of British, German and Polish scientists have revealed in a paper recently published in the journal Nature Catalysis. This suggests a new route could be exploited to tackle bacterial disease, they say.

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Bipedalism in humans may have come from foraging in treetops, research suggests

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Walking on two legs may not have been linked to environmental shifts, as previously thought

The ancestors of humans may have begun moving on two legs to forage for food among the treetops in open habitat, researchers have suggested, contradicting the idea that the behaviour arose as an adaptation to spending more time on the ground.

The origins of bipedalism in hominins around 7m years ago has long been thought to be linked to a shift in environment, when dense forests began to give way to more open woodland and grassland habitats. In such conditions, it has been argued, our ancestors would have spent more time on the ground than in the trees, and been able to move more efficiently on two legs.

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‘The sheer scale is extraordinary’: meet the titanosaur that dwarfs Dippy the diplodocus

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One of the largest creatures to have walked the Earth is to become the Natural History Museum’s new star attraction

It will be one of the largest exhibits to grace a British museum. In spring, the Natural History Museum in London will display the skeleton of a titanosaur, a creature so vast it will have to be shoehorned into the 9-metre-high Waterhouse gallery.

One of the most massive creatures ever to have walked on Earth, Patagotitan mayorum was a 57-tonne behemoth that would have shaken the ground as it stomped over homelands which now form modern Patagonia. Its skeleton is 37 metres long, and 5 metres in height – significantly larger than the museum’s most famous dinosaur, Dippy the diplodocus, which used to loom over its main gallery.

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Cool leaf! Study records chimp showing off object in human-like way

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Adult ape sharing information and just wanted mother to look at foliage with no motive otherwise, scientists say

Chimpanzees show each other objects just for the sake of it, researchers have found, revealing it isn’t only humans who like to draw attention to items that have captured their interest.

As anyone who has spent time with a child knows, even very young humans like to point out objects to others. However, it was previously thought this behaviour only occurs in our species.

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Australia gives world-first approval for faecal transplants to restore gut health

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BiomeBank in Adelaide collects healthy genetic material from the microbiomes of donors to treat potentially deadly bacterial condition

Australia has given regulatory approval for faecal transplants, the first country in the world to do so.

For such a transplant, poo donors – who have to meet a list of conditions – provide healthy genetic material from their microbiomes. The microbes are collected and delivered into the gastrointestinal tract of an unhealthy person, where they have been shown to treat conditions such as the potentially deadly bacteria Clostridium difficile colitis (C diff).

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