Girl with deadly inherited condition is cured with gene therapy on NHS

Teddi Shaw, from Northumberland, first recipient on health service of Libmeldy, world’s most expensive drug

A girl born with a rare and deadly genetic condition is expected to live a long and normal life after becoming the first person to be cured on the NHS with the help of a revolutionary gene therapy.

Teddi Shaw was diagnosed with metachromatic leukodystrophy (MLD), an inherited condition that causes catastrophic damage to the nervous system and organs. Those affected usually die young.

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Two arrested over suspected malicious messages in Nicola Bulley case

Man, 49, from Manchester and woman, 20, from Oldham held after reports messages being sent to Wyre council members

Two people have been arrested on suspicion of sending malicious communications to local councillors over the disappearance of Nicola Bulley, police have said.

Lancashire police received reports over the weekend of messages being sent to Wyre council members. A 49-year-old man from Manchester and a 20-year-old woman from Oldham have been arrested on suspicion of malicious communications offences.

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Brianna Ghey: candles and flower tributes laid at vigil for trans teenager

At least 300 people gather on Tuesday night to pay respect to 16-year-old girl stabbed to death in a Warrington park on Saturday

Candles and flowers have been laid out on the steps of St George’s Hall in Liverpool in tribute to Brianna Ghey, a trans teenager who was stabbed to death in a Warrington park on Saturday.

A crowd of at least 300 people, many of them also teenagers and young adults, gathered quietly on Tuesday night to pay respect to the 16-year-old, who her family described as “strong, fearless, one of a kind”.

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Legal victory in UK Japanese knotweed case could lead to more claims

Court of appeal ruled homeowner could recover loss of value even if knotweed has been treated

A significant legal victory in a case brought by a householder affected by Japanese knotweed has raised the prospect of an increase in claims from people stricken by the hazardous plant.

The court of appeal ruled that a homeowner could recover damages for a loss of value of their property from having had Japanese knotweed, even if it had been treated.

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Deal on Northern Ireland protocol ‘could be struck next week’

Negotiations are in crucial final phase with Rishi Sunak preparing to hold calls with EU leaders

Negotiations over the Northern Ireland protocol are in the crucial final phase with a deal possible as early as next week, according to multiple sources.

Rishi Sunak is expected to spend the latter half of the parliamentary recess this week looking at the shape of the deal, with calls pencilled in with EU leaders. However, UK sources stressed that talks were at a delicate phase and there was no guarantee of a final agreement.

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Rishi Sunak under pressure from backbench MPs to declare China a ‘threat’ – UK politics live

Latest updates: amid concerns over suspected spy balloons and as part of review of global security, PM urged to deliver hawkish view

A former British ambassador to the US and national security adviser has questioned whether the UK has a “watertight capability” to deal with suspected Chinese spy balloons.

Asked if prime minister Rishi Sunak is right to suggest the UK has a “watertight rapid response to intercept these kind of things”, Lord Kim Darroch told Times Radio he is not totally confident this is the case.

I’m not, to be honest, but I wouldn’t want listeners to get very worried about that.

I’m not because I think we have under-invested in defence for the last couple of decades – one might argue ever since the end of the cold war – and we don’t have all the kit and equipment that we really need and there are gaps around in the technology our armed forces have.

It’s still, I think, unless we discover something new, it’s still well-known technology and it’s still basically surveillance, still basically spying, and the reality is an awful lot of that goes on everywhere.

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Ford to cut nearly 4,000 jobs in Europe, including 1,300 in UK

US carmaker blames losses on rising costs and need to switch to electric vehicle production

The British car industry faces the prospect of further steep job cuts without urgent government support for electric vehicle investment, a union leader has warned, after Ford revealed 1,300 UK redundancies in its internal combustion operations.

The US carmaker said it planned to eliminate 3,800 product development and administration jobs across Europe, citing rising costs and the need to speed up its switch from petrol and diesel engines to electric vehicles.

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Sub-prime lender Amigo avoids £73m fine after claiming hardship

FCA finds company put customers at high risk of harm by failing to assess whether they could repay loans

The sub-prime lender Amigo has dodged a £73m fine despite having put consumers at a “high risk” of harm, amid fears that the financial penalty could have led to its collapse.

The Financial Conduct Authority (FCA) investigation found Amigo put business interests ahead of its customers, by failing to properly assess whether customers, or their guarantors, could afford to repay loans they applied for – noting faults in both its automated tech and human oversight between November 2018 and March 2020.

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Lilt to vanish from UK, rebranded as a totally tropical Fanta

We haven’t touched the taste, only the packaging, promises owner Coca-Cola

The soft drink Lilt has vanished from the UK after 48 years and has been rebranded as a new type of Fanta.

The tangy drink was launched in 1975 with the strapline “the totally tropical taste” and was sold only in the UK, Ireland, Gibraltar and Seychelles.

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Number of days lost to strikes is highest since the Thatcher era

Squeeze on households as pay growth falls at among fastest rates for 20 years

The number of working days lost to strike action last year reached the highest level since 1989, according to official figures showing that wage growth failed to keep pace with inflation amid the biggest real-terms fall on record.

The figures from the Office for National Statistics further highlight the squeeze on households in the cost of living crisis.

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Liz Truss oversaw jump in credit card spending at Foreign Office

Guardian analysis of data shows officials spent more under former PM than predecessor Dominic Raab

Liz Truss oversaw a major jump in spending on government credit cards at the Foreign Office when she took over, a Guardian analysis shows, with spending on restaurants, bars, leisure activities and hotels all rising sharply during her time in office.

An analysis of data collated by the Labour party shows officials spent far more on procurement cards under the former prime minister than they had under her predecessor, Dominic Raab.

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Leaders urged to ‘take a stand’ after violence outside Knowsley asylum hotel

Charities condemn policies that ‘demonise’ refugees after home secretary accused of victim blaming

Political leaders must “take a clear stand” and condemn violence against asylum seekers, charities have said, after the home secretary was accused of victim blaming after a riot outside a hotel in Merseyside.

Refugee organisations have signed an open letter after “horrifying” scenes on Friday outside the Suites hotel in Knowsley, which is housing asylum seekers. Fireworks were thrown at police and a police van was attacked with hammers and set alight.

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Clear chances missed to identify Wayne Couzens as danger to women

Police took no action after Couzens exposed himself three times before he went on to murder Sarah Everard

Police missed clear chances to identify Wayne Couzens as a potential sex offender and danger to women before he kidnapped and murdered Sarah Everard, it can finally be revealed.

He exposed himself three times, with witnesses recording either full registration details of vehicles he used, or partial details. But police took no action, leaving Couzens to continue as a serving Metropolitan police officer entrusted with a gun.

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UK embassy worker accused of spying had pro-Putin views, court told

Old Bailey hears legal argument about motivation of David Ballantyne Smith who has admitted eight charges

A security guard spying for Russia while working at the British embassy in Berlin was driven by an intense hatred for his own country and pro-Putin views, a UK court has heard.

David Ballantyne Smith pleaded guilty to eight charges under the Official Secrets Act in November 2022 for sharing confidential and sensitive material.

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Tories urge Jeremy Hunt to reverse army cuts in forthcoming budget

Planned 4% reduction in troop numbers should be abandoned in light of Ukraine war, say MPs and officials

Senior Tories are calling on Jeremy Hunt to abandon further cuts to the army by raising defence funding at next month’s budget, amid growing unease at the state of Britain’s military capabilities.

The chancellor has been urged by MPs to ensure the number of troops is held at the current level of about 76,000, instead of reducing it to 73,000 by 2025.

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US firm Liberty Global buys stake in Vodafone after tumultuous year

‘Cable cowboy’ John Malone rules out takeover bid but says he believes UK telecoms company is undervalued

The US telecoms group chaired by “cable cowboy” John Malone has snapped up a stake in Vodafone in a bet on the UK company’s revival – but has ruled out making a takeover bid.

Liberty Global, which is an investor in ITV and Virgin Media O2, told investors on Monday it had acquired a 4.92% stake in Vodafone, saying it believed the shares were undervalued.

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Tory vice-chair Lee Anderson faces libel claim over bribery allegations

Man who runs a food bank charity alleges MP for Ashfield defamed him in a Facebook post

A man who runs a food bank charity is pursuing a libel claim against the new vice-chair of the Conservatives, a law firm has said.

Michael Hollis alleges that Lee Anderson, who once claimed that people could feed themselves on 30p a day, defamed him in a Facebook post that he later refused to take down.

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Sunak rejects calls for BBC chair, Richard Sharp, to stand down

PM says he does not want to prejudge inquiry and that appointment was made after the ‘correct process’

Rishi Sunak has rejected calls for Richard Sharp to stand down as BBC chairman, despite the businessman failing to declare his role in arranging a secret £800,000 personal loan for Boris Johnson.

Sharp has been criticised by MPs for “significant errors of judgement” over his failure to mention his role in helping to arrange the loan for the former prime minister in early 2020. Johnson later appointed Sharp, a Conservative party donor, to oversee the BBC’s board.

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UK fighter jets always on standby, Sunak says after US shoots down objects

Prime minister will do ‘everything it takes’ to keep country safe as Britain conducts security review

UK fighter jets are on standby to shoot down Chinese spy balloons if any are spotted in British air space, the prime minister has said.

Rishi Sunak said Typhoon planes were ready at all times in case the UK came under threat from balloons such as the one US officials said they shot down last week.

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How one Derbyshire museum took initiative in returning Indigenous artefacts

Buxton Museum returned entire collection of Native American and First Nation artefacts to their original communities

When Taa.uu ‘Yuuwans Nika Collison first opened the email from Buxton Museum, she was, she says, “sort of in shock”.

Collison is a member of the Haida nation, the Indigenous inhabitants of a remote archipelago called Haida Gwaii off the very far north-west coast of Canada. For 25 years she and others had been lobbying museums and collectors around the world to return items made by her people back to their homeland, often with very little success. Here was a curator from a small town in Derbyshire she had never heard of, saying it had some Haida items in its collection, and it wanted to send them back.

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