Category Archives: Pharmaceuticals industry

‘Wall of secrecy’ in Pfizer contracts as company accused of profiteering

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US company faces scrutiny over Covid profits after UK agrees to secrecy clause

Ministers have agreed a secrecy clause in any dispute with the drugs manufacturer Pfizer over Britain’s Covid vaccine supply. Large portions of the government’s contracts with the company over the supply of 189m vaccine doses have been redacted and any arbitration proceedings will be kept secret.

The revelation comes as Pfizer is accused by a former senior US health official of “war profiteering’’ during the pandemic. In a Channel 4 Dispatches investigation to be broadcast this week, Tom Frieden, who was director of the US Centers for Disease Control and Prevention under Barack Obama, said: “If you’re just focusing on maximising your profits and you’re a vaccine manufacturer … you are war profiteering.”

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Covid: scientists find possible trigger for AstraZeneca jab blood clots

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Experts hope better understanding of rare side effect of vaccine could help ‘turn the tide’ on pandemic

Scientists believe they may have found the trigger behind the extremely rare blood clot complications stemming from the Oxford/AstraZeneca’s Covid vaccine.

According to a team of researchers from Cardiff and the US, the reaction can be traced to the way the adenovirus used by the vaccine to shuttle the coronavirus’s genetic material into cells binds with a specific protein in the blood, known as platelet factor 4 (PF4).

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Prince Harry compares Covid vaccine inequity to HIV struggle

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Duke of Sussex says on World Aids Day that vaccinating the world against Covid is ‘test of our moral character’

The Duke of Sussex has warned of “corporate greed and political failure” prolonging the Covid pandemic, comparing a “spectacular failure” of global vaccine equity to the struggle by millions to access HIV medicines.

In a letter read out at a World Health Organization (WHO) and UNAIDS event on World Aids Day, Prince Harry said lessons must be learned from the HIV/Aids pandemic.

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‘Follow the science’: AstraZeneca unveils £1bn R&D centre

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Anglo-Swedish pharmaceutical company has come a long way since it fought off a takeover bid in 2014

Little expense has been spared at the giant glass and steel structure that sprouts from a once-vacant plot of land on the outskirts of Cambridge.

AstraZeneca’s £1bn new research and development centre houses 16 labs and 2,200 scientists, making it the biggest science lab in Britain along with the Francis Crick Institute in London, and the pharmaceutical company’s biggest single site investment to date.

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Pregnant women at risk in Malawi as drug shortage prevents caesareans

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Patients travelling long distances to find surgery cancelled as lack of anaesthetics shuts operating theatres in half of hospitals

Almost half of Malawi’s district hospitals have closed their operating theatres due to a dire shortage of anaesthetics.

Maternity care has been affected by a lack of drugs, said doctors. Surgery, including caesareans, has been cancelled and patients needing emergency care have been moved hundreds of miles around the country.

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Covid live news: fourth wave hitting Germany with ‘full force’, Merkel warns; Belgium mandates working from home

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Angela Merkel calls for an extra push on vaccinations; Belgium tightens restrictions as cases rise in fourth wave

Agence France-Presse is reporting that delivery and logistics firm FedEx have announced it is closing its operations base in Hong Kong over the city’s quarantine requirements.

“As the global business environment continues to evolve and with the pandemic requirements in Hong Kong, FedEx has made the decision to close its Hong Kong crew base and relocate its pilots,” FedEx said in a statement to Hong Kong’s public broadcaster RTHK.

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UK firm to trial T-cell Covid vaccine that could give longer immunity

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Exclusive: Oxfordshire-based Emergex gets go-ahead for trials in Switzerland for skin patch vaccine

An Oxfordshire-based company will soon start clinical trials of a second-generation vaccine against Covid-19, an easy-to-administer skin patch that uses T-cells to kill infected cells and could offer longer-lasting immunity than current vaccines.

Emergex was set up in Abingdon in 2016 to develop T-cell vaccines, the brainchild of Prof Thomas Rademacher, the firm’s chief executive and professor emeritus of molecular medicine at the University College London medical school.

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Local Covid vaccines fill gap as UN Covax scheme misses target

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India, Egypt and Cuba among first states to develop and make their own vaccines as Covax falls behind

Developing countries are increasingly turning to homegrown Covid vaccinations as the UN-backed Covax programme falls behind.

While western countries roll out booster jabs to their own populations, Covax, which was set up by UN agencies, governments and donors to ensure fair access to Covid-19 vaccines for low- and middle-income countries, has said it will miss its target to distribute 2bn doses globally by the end of this year.

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WHO endorses use of world’s first malaria vaccine in Africa

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World Health Organization’s director general hails ‘historic day’ in fight against parasitic disease

The World Health Organization has recommended the widespread rollout of the first malaria vaccine, in a move experts hope could save tens of thousands of children’s lives each year across Africa.

Hailing “an historic day”, the WHO’s director general, Dr Tedros Adhanom Ghebreyesus, said that after a successful pilot programme in three African countries the RTS,S vaccine should be made available more widely.

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Coronavirus treatments: the potential ‘game-changers’ in development

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After positive clinical trials for antiviral drug Molnupiravir, it joins other medicines that have shown promise

The first clinical trial results showing a positive effect for a pill that can be taken at home has been hailed as a potential gamechanger that could provide a new way to protect the most vulnerable people from the worst effects of Covid-19. Molnupiravir joins a growing list of medicines that have shown promise. Here are some of the main developments in treatments so far.

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Big pharma fuelling human rights crisis over Covid vaccine inequity – Amnesty

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Six companies warned not to put profit before lives as report shows less than 1% of almost 6bn doses have gone to low-income countries

Amnesty International has accused six pharmaceutical companies that have developed Covid-19 vaccines of fuelling a global human rights crisis, citing their refusal to sufficiently waive intellectual property rights, share vaccine technology and boost global vaccine supply.

After assessing the performance of six Covid-19 vaccine developers – Pfizer and BioNTech, Moderna, Johnson & Johnson, AstraZeneca and Novavax – Amnesty International claims that all are failing to uphold their own human rights commitments and warns they should not be putting profit before the lives of people in the world’s poorest countries.

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Ministers told to bar EU from UK trial data in vaccines row

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England’s deputy medical chief asked for data to be withheld unless British vaccine guinea pigs allowed to travel abroad

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England’s deputy chief medical officer asked ministers to withhold all UK clinical trial data from the EU if European countries continued to deny entry to British vaccine trial volunteers, the Observer can reveal.

Jonathan Van-Tam made the extraordinary proposal after months of uncertainty for the 19,000 volunteers who are effectively unable to travel to Europe to see family, work or go on holiday because they took part in trials of Novavax and Valneva.

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Pfizer accused of holding Brazil ‘to ransom’ over vaccine contract demands

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Leaked supply document reveals clauses to protect US pharma company from legal action in the event of serious side-effects

Pfizer has been accused of holding Brazil “to ransom” over demands to shield itself from possible vaccine side-effect lawsuits in its contract to supply the country with 100m Covid jabs.

In its $1bn (£700m) deal with Pfizer Export BV, signed in March, despite its prior complaints, the Brazilian government agreed that “a liability waiver be signed for any possible side-effects of the vaccine, exempting Pfizer from any civil liability for serious side-effects arising from the use of the vaccine, indefinitely”.

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UK regulator approves ‘first of its kind’ Covid antibody treatment

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Sajid Javid says green light for Ronapreve – which was used to treat Donald Trump – is ‘fantastic news’

The antibody cocktail used to treat Donald Trump for Covid has been approved by the UK’s medicines regulator, becoming the first treatment in Britain using artificial antibodies to tackle the virus.

The drug, developed by the US biotech company Regeneron, has received the backing of the Medicines and Healthcare products Regulatory Agency (MHRA). Clinical trials showed it helped to prevent Covid infection as well as to reduce the risk of hospitalisation or symptoms in severe cases, when given soon after exposure.

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Covid-19 vaccines: the contracts, prices and profits

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Raised charges and Covax deals on order books of Pfizer, BioNTech, Moderna and AstraZeneca

Two US companies, Pfizer and Moderna, have raised the prices of their Covid-19 vaccines after data from clinical trials showed their mRNA formula was more effective than cheaper vaccines from Britain’s AstraZeneca and the American drugs maker Johnson & Johnson.

AstraZeneca and Johnson & Johnson have pledged to provide their doses on a not-for-profit basis until the pandemic ends.

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UK orders extra Covid vaccines for autumn 2022 booster campaign

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Pfizer reportedly asked to supply 35m more doses, with final go-ahead for this year’s programme still awaited

Ministers have started ordering vaccines for a booster campaign in autumn 2022, with Pfizer reportedly being asked to supply the UK with a further 35m doses.

The government has still not give the final go-ahead for the vaccine booster programme expected this autumn, but it is understood to have placed the order with Pfizer despite the company raising its prices.

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As Delta spreads, Pfizer and Moderna get set for a booster shot to profits

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The firms are already taking the lion’s share of earnings from the market, as this week’s results will show

Praised for preventing hundreds of thousands of deaths and allowing a return to more normal life, Covid vaccines will also substantially benefit some pharmaceutical companies.

In June, analysts estimated the global market for the vaccines could be worth $70bn (£50bn) this year, but the figure could be even higher as the Delta variant of coronavirus spreads and scientists debate whether people will need booster shots.

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Drug firm that hiked prices by 6,000% paid shareholders £400m

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Advanz Pharma and former private equity owners were fined £100m by markets watchdog

A pharmaceuticals firm that inflated thyroid drug prices by up to 6,000% over a decade paid out more than £400m to shareholders and directors during the same period.

London-based Advanz Pharma – and its former private equity owners HgCapital and Cinven – were fined a combined £100m by the Competition and Markets Authority (CMA) on Thursday.

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Is medical cannabis really a magic bullet?

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Research increasingly suggests that extracts from the plant are effective in treating pain, anxiety, epilepsy and more, but experts still preach caution around recreational use

In 2017, Mikael Sodergren, a liver and pancreatic cancer surgeon at Imperial College healthcare NHS trust, was finding himself becoming increasingly interested in the potential role of medical cannabis in treating pain, especially the discomfort experienced by patients after complex operations.

“I hope that I do a lot of good, but unfortunately in the short term, I inflict a lot of pain with cancer surgery,” says Sodergren. “So we’re reliant on pretty nasty painkillers, such as high-strength intravenous opioids, which we’re trying to move away from. They slow patients down and they cause complications.”

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I thought HIV meant death but it led me to fight to save millions of lives | Vuyiseka Dubula

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Twenty years ago in South Africa people were dying unable to access expensive antiretrovirals. The creation of the Global Fund was gamechanging

In 2001, at the age of 22 – when I thought my life had just begun – I was diagnosed with HIV. At that time, the diagnosis felt like a death sentence. Every day, I waited for my hour to die.

However, after two months of waiting, death didn’t come.

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