Cambridge scientists create world’s first living organism with fully redesigned DNA

Researchers create altered synthetic genome, in move with potential medical benefits

Scientists have created the world’s first living organism that has a fully synthetic and radically altered DNA code.

The lab-made microbe, a strain of bacteria that is normally found in soil and the human gut, is similar to its natural cousins but survives on a smaller set of genetic instructions.

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‘It would destroy it’: new international airport for Machu Picchu sparks outrage

Peruvian archaeologists decry new airport that would carry tourists directly to already fragile Inca citadel

Among the Inca archeological sites that abound in Peru, none draw nearly as many tourists as the famed citadel of Machu Picchu. There were more than 1.5 million visitors in 2017, almost double the limit recommended by Unesco, putting a huge strain on the fragile ruins and local ecology.

Now, in a move that has drawn a mixture of horror and outrage from archaeologists, historians and locals, work has begun on clearing ground for a multibillion-dollar international airport, intended to jet tourists much closer to Machu Picchu .

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Germany’s AfD turns on Greta Thunberg as it embraces climate denial

Rightwing populists to launch attack on climate science in vote drive before EU elections

Germany’s rightwing populists are embracing climate change denial as the latest topic with which to boost their electoral support, teaming up with scientists who claim hysteria is driving the global warming debate and ridiculing the Swedish climate activist Greta Thunberg as “mentally challenged” and a fraud.

The Alternative für Deutschland party (AfD) is expected to launch its biggest attack yet on mainstream climate science at a symposium in parliament on Tuesday supported by a prominent climate change denial body linked by researchers to prominent conservative groups in the US.

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100 years on: the picture that changed our view of the universe

Arthur Eddington’s photograph of the 1919 solar eclipse proved Einstein right and ushered in a century where gravity was king

A hundred years ago this month, the British astronomer Arthur Eddington arrived at the remote west African island of Príncipe. He was there to witness and record one of the most spectacular events to occur in our heavens: a total solar eclipse that would pass over the little equatorial island on 29 May 1919.

Observing such events is a straightforward business today, but a century ago the world was still recovering from the first world war. Scientific resources were meagre, photographic technology was relatively primitive, and the hot steamy weather would have made it difficult to focus instruments. For good measure, there was always a threat that clouds would blot out the eclipse.

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One-off injection may drastically reduce heart attack risk

Doctors hope to trial gene therapy on people with rare disorder in next three years

Doctors in the US have announced plans for a radical gene therapy that aims to drastically reduce the risk of heart attack, the world’s leading cause of death, with a one-off injection.

The researchers hope to trial the therapy within the next three years in people with a rare genetic disorder that makes them prone to heart attacks in their 30s and 40s. If the treatment proves safe and effective in the patients, doctors will seek approval to offer the jab to a wider population.

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Climate crisis: flooding threat ‘may force UK towns to be abandoned’

Environment Agency calls for urgent action to protect country from river and coastal floods

Entire communities might need to be moved away from coasts and rivers as the UK takes urgent action to prepare for an average global temperature rise of 4C, the Environment Agency warned.

The agency said on Thursday that difficult decisions would have to be taken in the coming years to make sure the UK was resilient amid flooding that would not be held back by higher land defences.

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Teenager recovers from near death in world-first GM virus treatment

Bacteria-killing viruses known as phages offer hope of solution to antibiotic resistance

A British teenager has made a remarkable recovery after being the first patient in the world to be given a genetically engineered virus to treat a drug-resistant infection.

Isabelle Holdaway, 17, nearly died after a lung transplant left her with an intractable infection that could not be cleared with antibiotics. After a nine-month stay at Great Ormond Street hospital, she returned to her home in Kent for palliative care, but recovered after her consultant teamed up with a US laboratory to develop the experimental therapy.

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Raise taxes on firms that harm nature, OECD tells G7 countries

Report calls for change of priorities and culture to avert catastrophic biodiversity loss

Governments need to ramp up investment in nature restoration and raise the tax burden on companies that degrade wildlife, according to recommendations made to the G7 group of rich nations.

The proposals are part of a growing debate on how to radically change humanity’s relationship with nature in the wake of a new UN mega-report that showed an alarming decline in the Earth’s life-support systems.

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Human society under urgent threat from loss of Earth’s natural life

Scientists reveal 1 million species at risk of extinction in damning UN report

Human society is in jeopardy from the accelerating decline of the Earth’s natural life-support systems, the world’s leading scientists have warned, as they announced the results of the most thorough planetary health check ever undertaken.

From coral reefs flickering out beneath the oceans to rainforests desiccating into savannahs, nature is being destroyed at a rate tens to hundreds of times higher than the average over the past 10m years, according to the UN global assessment report.

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5G signal could jam satellites that help with weather forecasting

New mobile system to be launched this year ‘will put lives at risk’

The introduction of 5G mobile phone networks could seriously affect weather forecasters’ ability to predict major storms.

That is the stark warning of meteorologists around the world, who say the next-generation wireless system now being rolled out across the globe is likely to disrupt the delicate satellite instruments they use to monitor changes in the atmosphere.

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Black hole may have swallowed neutron star, say astronomers

Scientists analyse whether gravitational wave detectors picked up signs of collision

Astronomers may have spotted a neutron star being swallowed by a black hole for the first time, marked by a belch of gravitational waves rippling across the cosmos.

If confirmed, the detection by the twin Ligo detectors in the US and the Virgo detector in Italy would be the first evidence that black holes and neutron stars can pair up in binary systems. The observations could also reveal new details about the nature of such dramatic mergers, including whether the neutron star was ripped apart before crossing the black hole’s threshold or whether it slid seamlessly into oblivion.

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Scientology cruise ship leaves St Lucia after measles quarantine

Church of Scientology vessel held in port after contagious disease detected onboard

A cruise ship quarantined for a reported case of measles has left the Caribbean island of St Lucia after health officials supplied 100 doses of vaccine to the ship, according to reports.

The Church of Scientology cruise ship was confined to port this week by island health officials after the highly contagious disease was detected onboard.

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End to Aids in sight as huge study finds drugs stop HIV transmission

Paper says risk between male partners is zero if virus fully suppressed by antiretrovirals

An end to the Aids epidemic could be in sight after a landmark study found men whose HIV infection was fully suppressed by antiretroviral drugs had no chance of infecting their partner.

The success of the medicine means that if everyone with HIV were fully treated, there would be no further infections.

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‘Spectacular’ jawbone discovery sheds light on ancient Denisovans

Scientists extract proteins from a molar to uncover details of mysterious species’ origins

A human jawbone found in a cave on the Tibetan plateau has revealed new details about the appearance and lifestyle of a mysterious ancient species called Denisovans.

The 160,000-year-old fossil, comprising a powerful jaw and unusually large teeth, suggests these early relatives would have looked something like the most primitive of the Neanderthals. The discovery also shows that Denisovans lived at extremely high altitude and, through interbreeding, may have passed on gene adaptations for this lifestyle to modern-day Sherpas in the region.

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International Space Station hit by major power shortage

SpaceX delivery delayed after old power-switching unit malfunctions

The International Space Station has been hit by a major power shortage that has forced a delivery from SpaceX to be delayed.

SpaceX was supposed to launch a shipment on Wednesday. But an old power-switching unit malfunctioned at the space station on Monday and knocked two power channels offline. The six remaining power channels still worked normally, according to Nasa.

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Italians try to crack Leonardo da Vinci DNA code with lock of hair

Hair tagged as polymath’s in US collection to be tested against remains in French grave

Two Italian experts are set to perform a DNA test on a lock of hair that they say might have belonged to Leonardo da Vinci.

The hair strand was found in a private collection in the US and will go on display for the first time at the Ideale Leonardo da Vinci museum in Vinci (the Tuscan town where the artist was born), from 2 May, the 500th anniversary of the artist’s death.

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‘Biodegradable’ plastic bags survive three years in soil and sea

Study found bags were still able to carry shopping despite environmental claims

Plastic bags that claim to be biodegradable were still intact and able to carry shopping three years after being exposed to the natural environment, a study has found.

The research for the first time tested compostable bags, two forms of biodegradable bag and conventional carrier bags after long-term exposure to the sea, air and earth. None of the bags decomposed fully in all environments.

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Scientific journal snubs academic over Sleeping Beauty metaphor

Professor Ton van Raan told use of phrase for ignored work is culturally insensitive

A leading American academic journal has refused to publish an article by a respected professor on the grounds that his use of the fairytale Sleeping Beauty as a metaphor for ignored scientific work is culturally insensitive and in danger of being “sexualised”.

Ton van Raan, a professor emeritus of quantitative science studies at Leiden University in the Netherlands, first likened the belated discovery of an academic work to the story of the Brothers Grimm fairytale some 15 years ago.

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Hand dryers v paper towels: the surprisingly dirty fight for the right to dry your hands

For a century, the humble paper towel has dominated public toilets. But a new generation of hand dryers has sparked a war for loo supremacy.

By Samanth Subramanian

In the summer of 2005, a Chicago marketing consultant named George Campbell received a tantalising call from a headhunter. Was he open to an interview at Dyson? The company was secretively preparing to launch a new appliance, and it needed a sales strategy for the US: that was all the headhunter would divulge. Campbell was excited; he saw Dyson as “a company with the iconic quality of Apple, and an ability to take a basic product like a vacuum cleaner and make an 80% margin on it”.

He went along to Dyson’s office, a factory-like space with lofty ceilings and timber beams next to the Chicago river. In his first few conversations, he recalled, they wouldn’t even reveal what the product was. Finally, Campbell was told in strict confidence: it was a hand dryer. And he’d thought he was joining Dyson for the glamour. “My heart dropped to my stomach.”

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Beyoncé rocks, but so did Woodstock | Brief letters

Roger Waters | Rock concerts | Use-by dates | Exercise | Smartphones

Regarding Jeremy Beecham’s thoughts on Roger Waters (Letters, 19 April), I think we can take it as read Waters would not encourage Madonna to support the Assad regime by playing Damascus.
John Warburton
Edinburgh

• You failed to mention the two most important filmed rock concerts (Homecoming review – Beyoncé documentary is a triumphant celebration, 19 April): Monterey Pop and Woodstock. To write about seminal filmed rock gigs without mentioning them is like writing about influential 60s groups without mentioning the Beatles or the Stones.
Jon Ingram
Ilkley, West Yorkshire

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