Missing Titanic submarine: US and Canadian teams search for tourist vessel

Race against time to find craft that went missing on Sunday with five people onboard, including British billionaire

US and Canadian rescue teams are scrambling to search for a tourist submarine that went missing during a voyage to the Titanic shipwreck with a British billionaire among the five people onboard.

Hamish Harding is the chair of the private plane firm Action Aviation, which said he was one of the mission specialists on the OceanGate Expeditions vessel reported overdue on Sunday evening about 435 miles south of St John’s, Newfoundland.

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‘Dramatic rise’ in number of women freezing eggs in UK

Experts say restrictions on socialising during Covid crisis may have led more women to seek to preserve fertility

There has been a dramatic rise in the number of women freezing their eggs in the UK, while more single people are opting for IVF, figures show.

A report from the Human Fertilisation and Embryology Authority (HEFA) found that more people than ever are undergoing procedures, with egg- and embryo-freezing the fastest-growing fertility treatments in Britain.

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Model embryo with heartbeat replicates cells in early pregnancy

Exclusive: Scientists used stem cells to create the structures, which were unable to develop into a foetus

Scientists have created a model human embryo with a heartbeat and traces of blood in an advance that offers an extraordinary window into the first weeks of life.

The synthetic structure, created from human stem cells without the need for eggs, sperm or fertilisation, replicated some of the cells and structures that would typically appear in the third and fourth week of pregnancy. But it was specifically designed to lack the tissues that go on to form the placenta and yolk sac in a natural embryo, meaning that it did not have the theoretical potential of developing into a foetus.

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‘Almost still shines’: 3,000-year-old sword unearthed in Germany

Object from mid-bronze age, in ‘extraordinary’ state of preservation, was found in grave in Bavaria

A bronze sword more than 3,000 years old , which is so well-preserved that it “almost still shines”, has been unearthed in southern Germany, officials say.

The Bavarian state office for the preservation of historical monuments (BLfD) said the sword, which is believed to date back to the end of the 14th century BC — the middle of the bronze age — was found during excavations last week in Nördlingen, between Nuremberg and Stuttgart.

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Alcohol in moderation may lower stress-related risk of heart disease, study finds

US researchers discover reduction of signalling in part of the brain could have significant impact on cardiovascular system

Light to moderate alcohol consumption may lower the risk of heart disease because it leads to long-term reductions in stress signalling in the brain, new research claims.

But cardiologists warn the cardiac benefits do not mean we should ignore other dangers of alcohol.

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China begins drilling one of world’s deepest holes in hunt for discoveries deep inside the Earth

Narrow 11,000-metre shaft will reach the Earth’s crust to study internal structures as China seeks to explore new frontiers

China has begun digging its deepest borehole in an effort to study areas of the planet deep beneath the surface.

The drilling of the borehole began on Tuesday in a desert in the Tarim basin in China’s north-western region of Xinjiang, according to the Chinese state-run Xinhua news agency. With a planned depth of 11,100 metres, the narrow shaft will penetrate more than 10 continental strata and reach the cretaceous system in the Earth’s crust – a series of stratified rocks dating back 145m years.

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Bowel cancer patients could be spared radiotherapy, US study suggests

Doctors found some patients could rely on chemotherapy and surgery alone to treat the disease

Thousands of bowel cancer patients could be spared radiotherapy, a study suggests, after doctors discovered they could rely on chemotherapy and surgery alone to treat their disease.

Radiotherapy has been used to treat bowel cancer patients for decades, but the side-effects can be brutal. It can cause problems that negatively affect quality of life, including infertility, the need for a temporary colostomy, diarrhoea, cramping and bladder problems.

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Sunak under fire as ‘stupid’ Eat Out to Help Out scheme to be focus of Covid inquiry

Leading scientist attacks prime minister as criticism mounts of government approach to science during the crisis

Rishi Sunak is facing a barrage of criticism in the run-up to the official Covid-19 inquiry as a leading scientist attacks his “spectacularly stupid” Eat Out to Help Out scheme, which is believed to have caused a sudden rise in cases of the virus.

The prime minister’s role as chancellor during the pandemic is under increasing scrutiny – as is that of his predecessor at No 10, Boris Johnson – in an escalating Covid blame game at Westminster as Lady Hallett prepares to open her investigation into the government’s pandemic response later this month.

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New migraine drug on NHS could help thousands of patients in England

Nice approves rimegepant for preventing migraines in cases where at least three previous treatments have failed

Thousands of people in England who get migraines could benefit from a drug that has been approved on the NHS.

The National Institute for Health and Care Excellence (Nice), the drugs regulator, said it was recommending rimegepant for preventing migraines in the approximately 145,000 adults where at least three previous preventive treatments had failed.

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Supermassive black hole at heart of ancient galaxy ‘far larger than expected’

Discovery of GS-9209, one of the furthest from the Milky Way, adds to evidence that large black holes prevent star formation, astronomers say

A supermassive black hole discovered at the heart of an ancient galaxy is five times larger than expected for the number of stars it contains, astronomers say.

Researchers spotted the immense black hole in a galaxy known as GS-9209 that lies 25bn light-years from Earth, making it one of the most distant to have been observed and recorded.

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China overtakes US in contributions to nature and science journals

Citations of Chinese research have risen because of sequencing of Covid-19 genome

China has overtaken the US to become the biggest contributor to nature-science journals, in a sign of the country’s growing influence in the world of academic research.

The Nature Index, which tracks data on author affiliations in 82 high quality journals, found that authors affiliated with Chinese institutions are more prolific than their US counterparts in physical sciences, chemistry, Earth and environmental sciences. The only category in which the US is still in the lead is life sciences.

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South China Sea shipwrecks give clues about historic Silk Road trade routes

Archaeologists begin excavation of two 500-year-old vessels filled with porcelain and timber

Two 500-year-old shipwrecks in the South China Sea, filled with Ming-era porcelain and stacked timber, provide significant clues about the maritime Silk Road trade routes, Chinese archaeologists have said.

The two shipwrecks were discovered in October, and cultural and archaeological authorities have now begun a year-long process of deep-sea exploration and excavation, government officials announced.

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Meteor blazes across north Queensland sky with blast of light and sound

Footage captured from Cairns on the east coast to Normanton on the Gulf of Carpentaria shows growing fireball exploding with a loud boom

The north Queensland sky was briefly set alight on Saturday night as a meteor blazed through the atmosphere, exploded, and came to earth with a tremendous boom.

Footage captured on smartphones, dashcams and security cameras by businesses and residents from Cairns on the east coast to Normanton on the Gulf of Carpentaria circulated on social media on Sunday, showing a fireball growing rapidly in size as it approached the Earth, followed by a blast of greenish-blue light.

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UK will lead on ‘guard rails’ to limit dangers of AI, says Rishi Sunak

PM sounds a more cautious note after calls from tech experts and business leaders for moratorium

The UK will lead on limiting the dangers of artificial intelligence, Rishi Sunak has said, after calls from some tech experts and business leaders for a moratorium.

Sunak said AI could bring benefits and prove transformative for society, but it had to be introduced “safely and securely with guard rails in place”.

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Developing country voices will be excluded at UN plastic talks, say NGOs

Limits on numbers at Paris summit mean some of those ‘most needing to be heard’ will not be in attendance

Scientists and NGOs have accused the UN’s environment programme (Unep) of locking out those “most needing to be heard” from upcoming negotiations in Paris aimed at halting plastic waste.

Last-minute restrictions to the numbers of NGOs attending what the head of Unep described as the “most important multilateral environmental deal” in a decade will exclude people from communities in developing countries harmed by dumping and burning of plastic waste as well as marginalised waste pickers, who are crucial to recycling, from fully participating, they said.

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Injectable HIV-prevention drug to be made in South Africa for the first time

Indian drug company to make cheaper generic version of CAB-LA, potentially protecting millions of people in Africa from the virus

An affordable version of a groundbreaking HIV-prevention drug will be made in South Africa for the first time, potentially giving millions of people at risk of HIV infection in Africa access to a two-monthly jab that can almost eliminate their chances of contracting the virus.

The Indian drug company Cipla confirmed that a generic version of the prophylaxis, long-acting cabotegravir (CAB-LA), would be manufactured at its plants in Benoni, near Johannesburg, or Durban.

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Potential antidote found for toxin in world’s most poisonous mushroom

Chinese and Australian researchers have identified that a dye used in medical imaging can block the toxic effects

Scientists believe they have found a potential antidote for a potent toxin found in the world’s most poisonous mushroom, the death cap.

The death cap mushroom, Amanita phalloides, is responsible for about 90% of mushroom-related deaths globally.

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Plans for UK ‘genomics transformation’ aim to act on lessons of Covid

Ten-year science strategy of UK Health Security Agency will use data to combat infectious diseases faster and more effectively

Health officials in the UK have drawn up plans for a “genomics transformation” that aims to detect and deal with outbreaks of infectious diseases faster and more effectively in the light of the Covid pandemic.

Information gleaned from the genetics of Covid proved crucial as the virus swept around the globe, revealing how the pathogen spread, evolved, and responded to a succession of vaccines and medicines developed to protect people.

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Overhaul UK fertility law to keep up with advancements, expert says

Exclusive: IVF in UK ‘is the most successful and the safest it has ever been’, says Tim Child

A leading fertility expert has said the law should be overhauled so that rapid advancements in reproductive science do not stall.

Prof Tim Child of the University of Oxford said IVF in the UK was “the most successful and the safest that it has ever been”, and noted that the chance of having a baby from a single embryo was rising and the likelihood of having multiple births dropping.

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Scientists criticise Nasa for scaling back mission to explore beyond Pluto

Anger at decision to axe the main task of the New Horizons spacecraft to probe the remote Kuiper belt

It may have reached the edge of the solar system and travelled more than 5 billion miles through space, but the New Horizons spacecraft is causing major ripples on Earth. A dispute has erupted between scientists and US space officials in the wake of Nasa’s decision to stop funding next year for the vessel’s main mission.

The move was described as “misguided and unfortunate” by Alan Stern, New Horizons’s principal investigator.

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