T-cell Covid immunity ‘present in adults six months after first infection’

Study suggests white blood cell levels higher in people who had symptoms

Cellular (T-cell) immunity against the virus that causes Covid-19 is likely to be present within most adults six months after primary infection, with levels considerably higher in patients with symptoms, a study suggests.

The data offers another piece of the puzzle that could be key to understanding whether previous Sars-CoV-2 infections – the virus behind Covid-19 – can prevent reinfection, and if so, for how long.

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‘It’s possible’: the race to approve a Covid vaccine by Christmas

At least three companies close to revealing results of phase three trials, but to be approved for use safety has to be ensured

The race for a Covid vaccine is reaching a crucial stage, with the glimmer of a possibility that one of the leading contenders will be approved by Christmas.

In an interview with the Guardian, Kate Bingham, who heads the UK’s vaccine taskforce, said the UK was in “a very good place”.

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Covid-19: what can we learn from the HIV/Aids pandemic? – podcast

Prof Ravi Gupta’s career has informed HIV treatment and curative strategies in the UK and at the Africa Health Research Institute. His treatment of a London patient is, to date, only the second ever successful treatment of an HIV patient, where the person remains long-term virus free. Gupta talks to Sarah Boseley about how a career in HIV research is informing the testing and treatment for Covid-19 and what we can learn in any parallels between the two viruses

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Remdesivir has very little effect on Covid-19 mortality, WHO finds

Results of major trial described as sobering, with drug found not to improve survival rates

Remdesivir, one of the big treatment hopes for Covid-19, has very little effect on preventing deaths, according to a large and comprehensive trial run by the World Health Organization.

The drug, made by the US biotech firm Gilead, has been talked up as a potential cure and was taken by Donald Trump. A trial in the US had previously showed it reduced the length of stay in hospital. But the gold-standard Solidarity WHO trial, which was based on a far larger sample – 3,000 people on the drug, compared with as many who were not – showed remdesivir had little effect on deaths over 28 days.

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Tardigrades’ latest superpower: a fluorescent protective shield

Scientists identify a species that appears to absorb potentially lethal UV radiation and emit blue light

The might be tiny creatures with a comical appearance, but tardigrades are one of life’s great survivors. Now scientists say they have found a new species boasting an unexpected piece of armour: a protective fluorescent shield.

Related: Tardigrades: Earth’s unlikely beacon of life that can survive a cosmic cataclysm

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BAME groups hit hard again as Covid second wave grips UK nations

As cases surge, figures show the demographics of those most seriously affected by coronavirus remain the same

One of the earliest signs that black, Asian and minority ethnic (BAME) people were being disproportionately harmed by the coronavirus pandemic came when the Intensive Care National Audit and Research Centre (ICNAR) published research in early April showing that 35% of almost 2,000 Covid patients in intensive care units in England, Wales and Northern Ireland were non-white.

A lot has happened in the intervening six months with numerous reports, including by the Office for National Statistics and Public Health England (PHE), confirming the increased risk to ethnic minorities and recommendations published on how to mitigate that risk. However, as the second wave intensifies, the demographics of those most seriously affected remain remarkably similar.

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Scientists get hands dirty with research into medieval poop

Study seeks to compare microbiomes of our ancestors for clues to modern diseases

Researchers working knee-deep in 14th- and 15th-century latrines have found that bacterial DNA from human excrement can last for centuries and provide clues to how our gut contents have changed significantly since medieval times.

Analysis of two cesspits, one in Jerusalem and the other in the Latvian capital, Riga, could help scientists understand if changes to our microbiome – the genetic makeup of the bacteria, virus, fungi, parasites and other microbes living inside us – affect modern-day afflictions.

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Well preserved 2,000-year-old brain cells found in Vesuvius victim

Brain of a young man killed in the eruption was found in Herculaneum, Italy

Brain cells have been found in exceptionally preserved form in the remains of a young man killed in the eruption of Mount Vesuvius almost 2,000 years ago, an Italian study has revealed.

The preserved neuronal structures in vitrified or frozen form were discovered at the archaeological site of Herculaneum, an ancient Roman city engulfed under a hail of volcanic ash after nearby Mount Vesuvius erupted in 79AD.

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Trump’s steroid Covid treatment adds to confusion over health

Dexamethasone ‘normally reserved for people going into respiratory failure’, says expert

The latest intervention from Donald Trump’s medical team has been to put the president on dexamethasone, a steroid that is proven, thanks to the UK’s Recovery trial, to benefit Covid-19 patients who are having breathing difficulties.

But the decision to administer the steroid now has only added to the confusion surrounding the president’s state of health. Normally, dexamethasone is reserved for patients who have been ill for at least a week and whose oxygen levels are low.

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40% of world’s plant species at risk of extinction

Race against time to save plants and fungi that underpin life on Earth, global data shows

Two in five of the world’s plant species are at risk of extinction as a result of the destruction of the natural world, according to an international report.

Plants and fungi underpin life on Earth, but the scientists said they were now in a race against time to find and identify species before they were lost.

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Botswana says it has solved mystery of mass elephant die-off

Elephants may have ingested toxins produced by bacteria found in waterholes

Hundreds of elephants died in Botswana earlier this year from ingesting toxins produced by cyanobacteria, according to government officials who say they will be testing waterholes for algal blooms next rainy season to reduce the risk of another mass die-off.

The mysterious death of 350 elephants in the Okavango delta between May and June baffled conservationists, with leading theories suggesting they were killed by a rodent virus known as EMC (encephalomyocarditis) or toxins from algal blooms.

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Coronavirus symptoms: how to tell if you have a common cold, flu or Covid

Fever, runny nose, headache? Lost your sense of taste or smell? Your guide to differentiating between the three illnesses

With winter approaching, the UK is entering the traditional seasons for colds and flu, with the additional complication this year that symptoms of those two illnesses can be broadly similar to those experienced by people who have caught the coronavirus and may be at risk of spreading it.

The NHS in England has produced a guide to differentiate between the three types of illnesses, which health experts hope will make it clearer to people whether they have an illness they would have most likely brushed aside last year, but which this year might lead them to think they need to self-isolate or seek to have a coronavirus test.

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Mutant virus: should we be worried that Sars-CoV-2 is changing?

Scientists tracking the virus have uncovered a major mutation, but it may not be as scary as it sounds

Scientists have had eyes on Sars-CoV-2, the virus that causes Covid-19, since the beginning of this pandemic.

They can see it is evolving, but it is happening at a glacial pace compared with two other viruses with pandemic potential: those that cause flu and Aids. That is good news for efforts to develop vaccines and treatments, but scientists remain wary that anything could still happen.

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I was infected with coronavirus in March, six months on I’m still unwell

Charlie Russell, 27, is one of an estimated 600,000 people with post-Covid illness, a condition that may give an insight into ME

It’s day 182 after being infected by Covid-19, and Charlie Russell is not doing the things that other 27-year-olds are doing.

He’s not running 5km three times a week like he used to. He’s not going to the pub. He’s not working. And he’s not getting better.

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Are aliens hiding in plain sight?

Several missions this year are seeking out life on the red planet. But would we recognise extraterrestrials if we found them?

In July, three unmanned missions blasted off to Mars – from China (Tianwen-1), the US (Nasa’s Mars 2020 Perseverance Rover) and the United Arab Emirates (Hope). The Chinese and American missions have lander craft that will seek signs of current or past life on Mars. Nasa is also planning to send its Europa Clipper probe to survey Jupiter’s moon Europa, and the robotic lander Dragonfly to Saturn’s moon Titan. Both moons are widely thought to be promising hunting grounds for life in our solar system – as are the underground oceans of Saturn’s icy moon Enceladus.

Meanwhile, we can now glimpse the chemical makeup of atmospheres of planets that orbit other stars (exoplanets), of which more than 4,000 are now known. Some hope these studies might disclose possible signatures of life.

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Plant clues could help find decomposing bodies, scientists say

Researchers looking at whether human remains cause changes that could be detected by drones

They can’t shout “whodunnit” but plants could offer vital clues when it comes to finding clandestine graves, researchers say.

Forensic experts in the US have begun experiments at a body farm – a facility where decay processes can be studied – to explore whether decomposing human remains leave their mark on surrounding vegetation, for example by affecting the colour of the leaves.

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How the race for a Covid-19 vaccine is getting dirty

Scientists worldwide are working against the clock to find a viable coronavirus vaccine – but are corners being cut for the sake of political gain and profit?

To begin with, it felt like a sleek performance from a well-honed relay team. On 11 January, only 10 days after reporting a new respiratory disease, the Chinese published the genome sequence of the virus that causes it. Researchers around the world set to work building vaccines against Covid-19, as the disease became known, and the first candidate entered human trials on 16 March; it was joined, as the months passed, by dozens of others.

Scientists were jubilant, and they had every right to be. They’d broken all vaccinology records to get to that point. But then tensions began to surface among the team members, and lately even the most distracted spectator will have noticed that they appear to be trying to nobble each other openly on the track. With accusations that the Russians and Chinese hacked research groups in other countries, biotech executives criticised for cashing in on their own, as yet unapproved vaccines, and Russia approving a vaccine that is still in clinical trials, the quest for a vaccine seems to have turned sour.

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Why do Covid fatalities seem steady when infection numbers are rising?

While some scientists believe the virus has become less deadly, others look at the factors that suggest otherwise

Are Covid-19 death rates decreasing?
Most statistics indicate that although cases of Covid-19 are rising in many parts of Europe and the United States, the number of deaths and cases of severe complications remain relatively low. For example, patients on ventilators have dropped from 3,000 at the epidemic’s peak in Britain to 70. At the same time, the number of cases in the UK have begun to rise in many areas.

What lies behind this trend?
Doctors are unsure exactly what is going on. Some suggest that medical interventions are more successful at treating those who suffer complications from the disease. For example, the drug dexamethasone was recently shown to improve survival rates among patients requiring ventilation. Others argue that different factors are involved. One suggestion is that Covid-19 is now becoming a disease of younger people who are less likely to die or suffer serious complications.

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Why do Covid fatalities remain low when infection numbers are rising?

While some scientists believe the virus has become less deadly, others look at the factors that suggest otherwise

Are Covid-19 death rates decreasing?
Most statistics indicate that although cases of Covid-19 are rising in many parts of Europe and the United States, the number of deaths and cases of severe complications remain relatively low. For example, patients on ventilators have dropped from 3,000 at the epidemic’s peak in Britain to 70. At the same time, the number of cases in the UK have begun to rise in many areas.

Why lies behind this trend?
Doctors are unsure exactly what is going on. Some suggest that medical interventions are more successful at treating those who suffer complications from the disease. For example, the drug dexamethasone was recently shown to improve survival rates among patients requiring ventilation. Others argue that different factors are involved. One suggestion is that Covid-19 is now becoming a disease of younger people who are less likely to die or suffer serious complications.

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‘Could I feel what they were doing? Yes’: Rob Delaney on the pain and pleasure of his vasectomy

The actor and comedian decided it was time to have the procedure after he and his wife had had four children. Here he writes candidly about the experience, and why it was the kindest cut

I got a vasectomy a few months ago. A vasectomy is when they cut and tie off the vas deferens, which are these little tubes in your ball sack (scrotum) so that there’s no sperm (sperm) in your jizz (semen) when you bust (ejaculate). I did this because my wife and I don’t want her to get pregnant again. It doesn’t mean we don’t want any more kids, it just means that if we did have any more, they’d have to be adopted or stolen or left to us because friends or family with young kids died in a plane crash or had their brain stems blown apart by less-lethal rounds fired at them at point-blank range while they were waiting in an 11-hour line attempting to vote in November.

I figured after all my wife, Leah, and her body had done for our family, the least I could do was let a doctor slice into my bag and sterilise me. Leah had taken birth control for decades, which is a giant pain in the ass and also decidedly sexist pharmacological slavery. IMAGINE a man having to remember to not only take a pill every day, but also having to deal with employer-provided private insurance prescription plans in the US which drop you or sell your plan to another company without telling you, among other crimes. And messing up once could land you with – for example – an ectopic pregnancy that isn’t diagnosed soon enough because you’re afraid to go to the doctor due to your high deductible, so you literally die and are dead, in a cemetery. I think I speak for my bros when I say: “No thanks!”

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