Which disease-modifying Alzheimer’s drugs are the most promising?

Many drugs in development aim to delay, slow or reverse symptoms, but which are causing the biggest stir?

This week England’s health spending watchdog rejected a new Alzheimer’s drug – the second such drug it has turned down this year.

Both donanemab and lecanemab were approved by the UK’s Medicines and Healthcare products Regulatory Agency (MHRA), yet the National Institute for Health and Care Excellence (Nice) said their benefits were too small to justify their costs, while there have also been concerns over potential side-effects – such as brain swelling and bleeding.

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Alarm at first fall in disadvantaged students in England reaching university

Proportion of students eligible for free school meals at 15 who progress to higher education falls from 29.2% to 29%

The proportion of disadvantaged teenagers in England going on to study at university has fallen for the first time on record, leading to accusations that the country is moving backwards in terms of social mobility.

Figures released by the Department for Education show that 29% of students eligible for free school meals at 15 had progressed to university by the age of 19 in 2022-23, compared with 29.2% the previous year – the first time the rate has fallen since it was first measured in 2005-06.

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Trans children’s charity told to rewrite guidance on puberty blockers

Charity Commission investigation also said there had been mismanagement within Mermaids

A charity supporting gender-questioning young people has been told to rewrite its guidance about the risks of puberty blockers, after a two-year Charity Commission investigation, which also concluded that there had been mismanagement within the organisation.

However, the investigation found that the charity, Mermaids, had appropriate safeguarding policies in place and there was no evidence that it provided medical advice to children, which would have been outside its remit.

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Special educational needs bill in England hits record £10bn a year

National Audit Office report finds no signs of improvement in lives of pupils despite record spending

The bill for special needs education in England has hit £10bn a year, with the number of children and young people entitled to government support in the form of education, health and care plans set to double to 1 million within a decade, a landmark report has found.

The investigation by the National Audit Office (NAO) found that despite record levels of spending there had been no signs of improvement in the lives of children with special educational needs (SEN).

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NHS in England to trial AI tool to predict risk of fatal heart disease

‘Superhuman’ technology known as Aire can detect potential problems doctors cannot see from ECG results

The NHS in England is to trial a “superhuman” artificial intelligence tool that predicts a patient’s risk of disease and dying early.

The new technology, known as AI-ECG risk estimation, or Aire, is trained to read the results of electrocardiogram (ECG) tests, which record the electrical activity of the heart and are used to check for problems.

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Woman, 60, arrested on suspicion of manslaughter over Dorset care home deaths

Police confirm ‘possible carbon monoxide poisoning’ is main line of inquiry after fatalities at care home in Swanage

A 60-year-old woman has been arrested on suspicion of manslaughter by detectives investigating the deaths of three people at a care home in Dorset.

Officers are still treating the deaths at the Gainsborough care home in Swanage as unexplained and have confirmed that “possible carbon monoxide poisoning” is the primary line of inquiry. Seven other residents were taken to hospital.

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‘Horror and tears’ as Lebanon’s hospitals fear same fate as Gaza

Israeli strikes near Rafik Hariri hospital and its claims that a second Beirut facility is hiding Hezbollah stash cause anxiety and panic

The rescuers struck at the concrete with jackhammers, excavators and even pickaxes, pausing occasionally and demanding silence, straining to hear anyone still trapped under the collapsed building.

Beneath the rubble, nothing stirred. They resumed, many working through the night after Israel carried out airstrikes on residential buildings across the street from Rafik Hariri university hospital, killing 18 people, including four children, and wounding 60 on Monday night.

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Ian Paterson pitched cleavage-sparing mastectomy ‘like sales job’, inquest told

Procedures performed by convicted breast surgeon were not a recognised or authorised type of operation

The convicted breast surgeon Ian Paterson pitched one of his patients an unauthorised cleavage-sparing mastectomy “almost like a sales job”, an inquest has heard.

Chloe Nikitas, an environmental consultant from Tamworth, died in 2008 at the age of 43 from breast cancer that returned three years after having a mastectomy she believed had removed all of her breast tissue.

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Surrogacy ring accused of exploiting vulnerable women in Argentina

Prosecutors say ‘criminal enterprise’ charged foreign couples $50,000 and denied payments for miscarriages

An international surrogacy ring exploited impoverished women, denied payments for miscarriages, and “commercialised” babies in Argentina, prosecutors have alleged.

A team of prosecutors said they had discovered a “criminal enterprise” which has been charging foreign couples about $50,000 for a baby born by surrogacy in Argentina.

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Top female footballers urge Fifa to end deal with Saudi ‘nightmare sponsor’

Letter to governing body accuses Saudis of using sports to ‘distract from the regime’s brutal human rights reputation’

More than 100 professional female footballers have signed a letter calling on Fifa to end its sponsorship deal with the state-owned Saudi Arabian oil company, Aramco, accusing Saudi authorities of “brutal human rights violations”.

A four-year deal signed in April will see Aramco, which is 98.5% state-owned, sponsor major tournaments including the men’s World Cup in 2026 and the Women’s World Cup in 2027.

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Despair in Chad camps as violence and hunger in Sudan drive 25,000 across border in a week

Warning of ‘lost generation’ in Adré and Farchana camps as Sudan’s civil war drives huge numbers across border

Refugees and aid agencies have warned of deteriorating conditions in overcrowded and severely underfunded camps in Chad, as intensifying violence and a hunger crisis in Sudan drive huge numbers across the border.

About 25,000 people – the vast majority women and children – crossed into eastern Chad in the first week of October, a record number for a single week in 2024. Chad, one of the world’s poorest countries, hosts 681,944 Sudanese refugees – the highest number globally.

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Half of UK workforce lack access to workplace health support, report finds

Study by Royal Society for Public Health shows current system could further exacerbate health inequalities

Almost half of the UK workforce lack access to workplace health support including winter flu vaccinations and checks for cardiovascular diseases, a report has found.

The analysis, by the Royal Society for Public Health (RSPH), looked at data from the Department for Work and Pensions and the Department for Business, Energy and Industrial Strategy (DBEIS) and found that more than 10 million UK workers lack access to services including basic health checks, vaccinations, and smoking or weight loss support, provided by their employer.

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Wes Streeting unveils plans for ‘patient passports’ to hold all medical records

Health secretary launches consultation on government’s move to transform NHS in England from ‘analogue to digital’

Wes Streeting is to unveil plans for portable medical records giving every NHS patient all their information stored digitally in one place on Monday, despite fears over breaching privacy and creating a target for hackers.

The health secretary is launching a major consultation on the government’s plans to transform the NHS from “analogue to digital” over the next decade. It will offer “patient passports” containing health data that can be swiftly accessed by GPs, hospitals and ambulance services.

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Wes Streeting denies ‘dystopian future’ over weight-loss jabs for unemployed

UK health secretary says people will not be ‘involuntarily jabbed’ but that medications could be ‘gamechanging’

Wes Streeting has denied his plans to give new weight-loss jabs to unemployed people to help them back into work would result in a “dystopian future” where overweight people would be “involuntarily jabbed”.

The UK health secretary acknowledged that weight-loss drugs were not, on their own, the answer to the nation’s obesity crisis after he suggested this week that they could have a “monumental” impact on getting more people working.

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Rachel Reeves will tax businesses to plug £9bn black hole in NHS

The chancellor is set to announce a revenue-raising budget designed to reset Britain’s public finances

Rachel Reeves is set to use one of the most pivotal budgets of recent times to call on businesses to pay more tax to help restore the NHS, amid warnings that the health service has been left with a £9bn hole in its finances.

The chancellor is expected to stake her reputation on a tax-­raising budget designed as a reset of the public finances. She has already had to deal with cabinet skirmishes over funding unveiled alongside the statement. However, Reeves is understood to believe that the public will accept a multibillion-pound hike in business taxes if it is linked to repairing the health system’s finances.

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Modern day grave robbers are using emojis and codewords to secretly trade real human bones

The trade is flourishing online, experts say, as bone collectors exploit legal loopholes to buy and sell human remains

A modern form of “grave robbery” is flourishing online, experts say, as bone collectors exploit legal loopholes to buy and sell human remains.

In Australia, where it is illegal to buy or sell human remains (albeit with some exceptions), people sell photographs of the remains then add the bones as a “gift”.

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Ban smacking in England now, says children’s commissioner

Rachel de Souza makes strongest intervention yet as three relatives go on trial for murder of Sara Sharif, the 10-year-old who allegedly suffered two years of abuse by her father

Ministers must ban smacking now, the children’s commissioner for England has said, in her strongest intervention yet on child safety.

Rachel de Souza said that banning smacking was “a necessary step” to keep children safe, and that bans in Scotland and Wales had “taught us we need to take that step in England too”, adding “now is the time to go further”.

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Psychotherapists in England must be regulated, experts say, after abuse claims rise

Exclusive: Lack of formal oversight means anyone can set up in practice and continue to work after misconduct cases, campaigners say

Ministers face calls for the urgent regulation of psychotherapists and counsellors to protect vulnerable people, as lawyers report a rise in lawsuits by patients for alleged harm done during therapy.

Unlike most other healthcare roles, including doctors, midwives and osteopaths, “psychotherapist” and “counsellor” are not protected titles nor statutorily regulated professions in the UK.

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When therapy goes wrong: the problem of underqualified practitioners

In the age of influencer therapists and mental health apps, experts say the public need to be better informed

From influencer therapists on social media to psychotherapy platforms advertising on TV and radio, going to see a therapist is increasingly mainstream – yet many people know little about who they are seeing and what they are getting.

Experts said more information and awareness among the public of how therapy works was desperately needed, to minimise the risks of making their mental health worse.

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NHS set to receive 4% budget rise but health chiefs say it may not be enough

Whitehall source says it would only allow NHS to ‘stand still’ on waiting lists rather than reduce them

The NHS is set to get an inflation-busting 4% rise in its budget next year but health chiefs have said it may not allow them to cut waiting lists for another 18 months, the Guardian has learned.

The health service is on course to be one of the big winners in Rachel Reeves’s spending review on 30 October if it gets a proposed 4% real-terms uplift from the Treasury.

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