Category Archives: Pharmaceuticals industry

Australian drugmakers hit by critical shortages at height of pandemic, inquiry hears

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Evidence given to parliamentary committee sparks new calls to develop national capability to manufacture medicines and key supplies

Australian companies were “shocked” to experience price-gouging and had trouble accessing critical supplies to make medicines and personal protective equipment at the height of the pandemic, a parliamentary committee has been told.

It has prompted fresh calls for Australia to build up its ability to manufacture critical drugs “without reliance on opaque and fragile offshore supply chains”.

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The Lancet’s editor: ‘The UK’s response to coronavirus is the greatest science policy failure for a generation’

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Richard Horton does not hold back in his criticism of the UK’s response to the pandemic and the medical establishment’s part in backing fatal government decisions

There is a school of thought that says now is not the time to criticise the government and its scientific advisers about the way they have handled the Covid-19 pandemic. Wait until all the facts are known and the crisis has subsided, goes this thinking, and then we can analyse the performance of those involved. It’s safe to say that Richard Horton, the editor of the influential medical journal the Lancet, is not part of this school.

An outspoken critic of what he sees as the medical science establishment’s acquiescence to government, he has written a book that he calls a “reckoning” for the “missed opportunities and appalling misjudgments” here and abroad that have led to “the avoidable deaths of tens of thousands of citizens”. 

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UK hospitals to trial five new drugs in search for coronavirus treatment

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Exclusive: thirty hospitals looking to sign up hundreds of patients to take part in studies

Five new drugs are to be trialled in 30 hospitals across the country in the race to find a treatment for Covid-19, it has emerged.

Just days after global trials of hydroxychloroquine, the drug promoted by Donald Trump as a cure, were halted, British scientists are looking to sign up hundreds of patients for trials of medicines they hope will prevent people becoming ill enough to need intensive care or ventilators.

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Crab blood to remain big pharma’s standard as industry group rejects substitute

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Animal rights groups have been pushing a synthetic alternative to horseshoe crab blood in drug safety testing

Horseshoe crabs’ icy-blue blood will remain the drug industry’s standard for safety tests after a powerful US group ditched a plan to give equal status to a synthetic substitute pushed by Swiss biotech Lonza and animal welfare groups.

The crabs’ copper-rich blood clots in the presence of bacterial endotoxins and has long been used in tests to detect contamination in shots and infusions.

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Exclusive: big pharma rejected EU plan to fast-track vaccines in 2017

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World’s top drug firms turned down proposals for work on pathogens like coronavirus

The world’s largest pharmaceutical companies rejected an EU proposal three years ago to work on fast-tracking vaccines for pathogens like coronavirus to allow them to be developed before an outbreak, the Guardian can reveal.

The plan to speed up the development and approval of vaccines was put forward by European commission representatives sitting on the Innovative Medicines Initiative (IMI) – a public-private partnership whose function is to back cutting-edge research in Europe – but it was rejected by industry partners on the body.

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US and UK ‘lead push against global patent pool for Covid-19 drugs’

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Efforts to dilute world health assembly resolution on open licensing decried as ‘appalling’

Ministers and officials from every nation will meet via video link on Monday for the annual world health assembly, which is expected to be dominated by efforts to stop rich countries monopolising drugs and future vaccines against Covid-19.

As some countries buy up drugs thought to be useful against the coronavirus, causing global shortages, and the Trump administration does deals with vaccine companies to supply America first, there is dismay among public health experts and campaigners who believe it is vital to pull together to end the pandemic.

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Global report: leaders urge free vaccines as France allows staycations

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French drugmaker criticised for giving US priority; Gordon Brown says Covid-19 solution is global

More than 140 world leaders and experts have called for future Covid-19 vaccines to be made available to everyone free of charge, amid growing tensions between drug companies and governments and a boycott of vaccine summits by the US.

Vaccines and treatments for the virus should not be patented, say the signatories to an open letter published in the run-up to next week’s meeting of the World Health Assembly, the policy-setting body of the UN’s World Health Organization. Instead, scientific breakthroughs must be shared across borders, they urge.

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Covid-19 could mark a deadly turn in Ghana’s fight against fake drugs

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With substandard medicines already in wide circulation, fears are growing that coronavirus could create a lethal ‘parallel crisis’

When Joana Opoku-Darko’s daughter Anna was 18 months old, she came down with malaria, a disease common in Ghana and especially deadly for children.

She bought medication from a pharmacy in Ghana’s capital, Accra; when Anna’s fever didn’t subside she took her to a hospital, where they ran some tests.

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World’s stock markets soar on coronavirus treatment hopes

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Investors shrug off US growth gloom after promising data from remdesivir drug trial

Shares have soared on the world’s stock markets after investors shrugged off a deep slump in the US economy and pinned their hopes on a possible breakthrough in treatment for Covid-19.

Despite news that the longest expansion in US history came to an abrupt end in the first three months of 2020, financial markets were buoyed by an update from the American biopharma company Gilead Sciences on its experimental drug remdesivir.

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Paracetamol cannot treat coronavirus, NSW chief health officer says, only its symptoms – video

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New South Wales chief health officer Dr Kerry Chant addresses a misconception around paracetamol and the coronavirus crisis. With pharmacies and stores running low on supplies of the painkiller due to hoarding, Chant explained paracetamol only treats symptoms of Covid-19, not the virus itself

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Brexit threatens UK’s ability to respond to a future pandemic

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The coronavirus should remind us of just why international cooperation is so important in reducing the threat of infectious disease
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Brexit threatens the UK’s ability to respond to the novel coronavirus and future pandemics

The coronavirus pandemic could not have come at a worse time for the UK and its citizens. Just as UK government ministers are digging in for the really difficult part of Brexit, the negotiations on future relationships with the EU and the rest of the world, a new virus comes out of China that reminds us of just why international co-operation is so important.

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Revealed: Monsanto’s secret funding for weedkiller studies

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The research, used to help avoid a ban, claimed ‘severe impacts’ on farming if glyphosate was outlawed

Monsanto secretly funded academic studies indicating “very severe impacts” on farming and the environment if its controversial glyphosate weedkiller were banned, an investigation has found.

The research was used by the National Farmers’ Union and others to successfully lobby against a European ban in 2017. As a result of the revelations, the NFU has now amended its glyphosate information to declare the source of the research.

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Purdue payments to Sackler family surged after OxyContin fine

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Family started taking far more money out of firm after it was fined for misleading marketing of drug

The wealthy owners of OxyContin maker Purdue Pharma started taking far more money out of the company after it was fined for misleading marketing of the powerful prescription painkiller.

Purdue made payments for the benefit of members of the Sackler family totalling $10.7bn (£8bn) from 2008 through to 2017, a court filing made by the company on Monday evening shows.

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Zantac in global recall over ‘unacceptable’ levels of potential carcinogen

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Heartburn medicine pulled by GlaxoSmithKline while it investigates source of impurity

GlaxoSmithKline is recalling the popular heartburn medicine Zantac in all markets, days after the US Food and Drug Administration (FDA) found “unacceptable” levels of probable cancer-causing impurity in the drug.

Zantac, also sold generically as ranitidine, is the latest drug in which cancer-causing impurities have been found. Regulators have been recalling some blood pressure and heart failure medicines since last year.

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US attack on WHO ‘hindering morphine drive in poor countries’

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Claims have hurt efforts to help people around world in acute pain, say palliative care experts

An attack on the World Health Organization (WHO) by US politicians accusing it of being corrupted by drug companies is making it even more difficult to get morphine to millions of people dying in acute pain in poor countries, say experts in the field.

Representatives of the hospice and palliative care community said they were stunned by the Congress members’ report, which they said made false accusations and would affect people suffering in countries where almost no opioids were available.

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OxyContin maker Purdue Pharma files for bankruptcy

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Move is partly aimed at halting more than 2,000 lawsuits filed against drug firm

US drug-maker Purdue Pharma has filed for bankruptcy and announced a $10bn (£8bn) plan to settle thousands of lawsuits that accuse the company’s prescription painkiller, OxyContin, of fuelling the deadly opioids crisis.

The company, owned by the billionaire Sackler family, faces more than 2,000 lawsuits, including actions from nearly all US states and many local governments, which allege Purdue falsely promoted OxyContin by downplaying the risk of addiction. The public health crisis claimed the lives of nearly 400,000 people between 1999 and 2017, according to the latest US data.

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The science of senolytics: how a new pill could spell the end of ageing

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A simple treatment to stave off the health problems of old age could be available in five to 12 years. Here’s how it would work

The science of extending life is a subject of morbid fascination, conjuring the image of old billionaires being cryogenically frozen. But imagine if, instead of a pill you could take to live for ever, there was a pill that could push back the ageing process – a medicine that could stave off the fragility, osteoarthritis, memory loss, macular degeneration and cancers that plague old age.

It could happen, with the science of senolytics: an emerging – and highly anticipated – area of anti-ageing medicine. Many of the world’s top gerontologists have already demonstrated the possibilities in animals and are now beginning human clinical trials, with promising results. If the studies continue to be as successful as hoped, those who are currently middle-aged could become the first generation of oldies who are youthful for longer – with a little medical help.

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Opioids addiction rising in India as US drugmakers push painkillers

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As the Indian government loosens its prescription opioid laws after decades of lobbying by palliative care advocates, the cash-fed healthcare system is ripe for misuse

In the crowded waiting room of Dr Sunil Sagar’s clinic, in the working-class neighborhood of Bhagwanpur Khera, a toddler breathes from a nebulizer. The patients sit, motionless, but there is somehow tremendous noise. The clinic is a squat cement building draped in wires, a red cross on the door. Sagar sits behind a desk in a small, open room, as a squad of assistants escort patients to him.

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Johnson & Johnson responsible for fueling opioid crisis in Oklahoma, judge rules

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In landmark case, Oklahoma is first state to sue an opioid manufacturer all the way to trial as judge orders orders company to pay $572m

An Oklahoma judge has found Johnson & Johnson liable in a lawsuit claiming the giant drug maker helped fuel the deadly opioid epidemic in the state.

Oklahoma is the first state to sue an opioid manufacturer in court all the way to trial.

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Ebola now curable after trials of drugs in DRC, say scientists

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Congo results show good survival rates for patients treated quickly with antibodies

Ebola can no longer be called an incurable disease, scientists have said, after two of four drugs being trialled in the major outbreak in the Democratic Republic of the Congo were found to have significantly reduced the death rate.

ZMapp, used during the massive Ebola epidemic in Sierra Leone, Liberia and Guinea, has been dropped along with Remdesivir after two monoclonal antibodies, which block the virus, had substantially more effect, said the World Health Organization and the US National Institute of Allergy and Infectious Diseases, which was a co-sponsor of the trial.

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