Sister of man who died after AstraZeneca jab urges public to have vaccine

Dr Alison Astles says her brother, Neil Astles, was ‘extraordinarily unlucky’ because risk of dying from vaccine is tiny

The sister of a man who died from a rare blood clot on the brain after receiving the AstraZeneca vaccine has urged the public to “keep saving lives” by continuing to receive the jab.

Neil Astles, a 59-year-old solicitor at Warrington council, was given his first dose on 17 March but died in hospital on Easter Sunday after suffering from 10 days of worsening headaches and loss of vision.

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Australian Covid vaccine rollout in disarray as AstraZeneca doses given blood clot warning for under-50s

Australian government yields to expert advice that Pfizer should now be the preferred coronavirus vaccine for adults under the age of 50

Australia’s vaccine rollout has suffered a major shock, with an advisory slapped on the AstraZeneca vaccine warning people under 50 it may cause extremely rare but potentially deadly blood clots.

On Thursday evening, the Australian government announced it had accepted expert advice that Pfizer should now be the preferred vaccine for under 50s, who will be warned AstraZeneca should only be taken if it is clear the benefits outweigh the risks.

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UK Covid variant now most common in US, says CDC chief – video

The B117 variant of coronavirus first detected in the UK is now the most dominant in the US, the director of the Centers for Disease Control and Prevention said on Wednesday.

During the White House coronavirus response team’s briefing, Dr Rochelle Walensky warned the rising number of coronavirus cases in dozens of US states is probably attributable to the spread of variants 

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‘Think of others’: elderly people in Zimbabwe dispel scepticism on Covid vaccine

While younger generations remain suspicious, growing numbers of senior citizens are taking up the jab

They may be old, frail, and vulnerable but they are the foot soldiers at the front of Zimbabwe’s Covid vaccination drive. Amid widespread scepticism among the younger population, it is elderly people who are coming out to lead by example.

The queues at the vaccination centres in the capital, Harare, are dominated by older people. At Wilkins Hospital, Felda Mupemhi, 85, grasps her walking stick as she trudges toward a white tent, where nurses are administering the Sinopharm vaccine.

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What do I need to know about the Oxford/AstraZeneca vaccine?

After a UK recommendation that healthy adults under 30 should have an alternative jab, here’s the latest information and advice

Concerns have been mounting over reports of rare but serious blood clots in a small number of recipients of the Oxford/AstraZeneca vaccine, leading to a UK recommendation on Wednesday that healthy adults under 30 should have an alternative jab if they can. We take a look at the latest information and guidance.

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India carries out record 4.3m daily Covid jabs as cases continue to rise

Country reports 115,000 fresh infections in 24 hours, the highest single-day total anywhere in world

India has carried out a record 4.3m daily vaccinations as its second wave of coronavirus continued its rapid spread, with 115,000 fresh infections in 24 hours – the highest single-day total anywhere in the world.

While the vaccination rate, which had been been hovering at between 2-3m a day, was a triumph it was not enough to quell the sense of despondency over the sharp increase in cases.

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Doubts over Russian Covid vaccine doses delay rollout in Slovakia

Sputnik V order that led to PM’s resignation cannot be used owing to incomplete or inaccurate information

A 200,000-dose order of Russia’s Sputnik V vaccine that triggered a political crisis in Slovakia should not be administered yet because of incomplete or inaccurate information from the manufacturer, the national medicines agency has said.

The Dennik N news site quoted the agency as saying it could not properly assess the shots, which it said were different from the vaccine whose favourable peer-reviewed late-stage trial results were published in The Lancet medical journal in February.

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Australia news live: mass Covid vaccination hub for Sydney could be operational in ‘couple of months’

Gladys Berejiklian says a NSW Covid immunisation centre will be capable of administering 30,000 doses a week; EU denies blocking further shipments of AstraZeneca earmarked for Australia. Follow the latest updates, live

Australia needs to manage the increasingly complex relationship with China, even as the government seeks areas to diversify its export markets, according to a new report out this afternoon.

The Asia Taskforce – which includes the Business Council of Australia and Asia Society Australia – calls for a target of boosting Australia’s exports to 35% of GDP by 2030 (up from 29% in 2019).

Popular support for the open economy cannot be taken for granted. Retreating to old familiar relationships in western markets, falling behind in Asia literacy and failing to build connections with new Asian business partners should not be seen as a serious default choice when consumption in Asia will likely fuel future global growth.

The Greens are once again calling for an independent rapid review into the vaccine rollout to identify any issues and restore public confidence.

Senator Rachel Siewert, Greens spokesperson for health, said in a statement:

With targets missed, persistent problems with vaccine supply, and troubles getting the available vaccines to where they’re needed, the rollout of these vital jabs hardly inspires confidence...

We shouldn’t let this devolve into a game of finger pointing and blaming shifting between the federal and state governments. This pointless squabble doesn’t inspire confidence in the rollout, and can only serve to add further delays to the process.

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Scott Morrison calls on European Union to supply outstanding AstraZeneca Covid vaccine doses

Australia has accused the EU of ‘semantics’ after European Commission said just one shipment of 250,000 AstraZeneca doses has been formally blocked, but Coalition says AZ has not been able to secure an export licence from Europe

Scott Morrison denies his government has presented the public with overly rosy assessments about the state of its Covid-19 vaccine rollout, as he steps up calls for the European Union to allow 3.1m outstanding AstraZeneca doses to be shipped to Australia.

While declaring that vaccine supply issues were a matter of “straightforward maths”, the prime minister also attempted to calm a growing diplomatic dispute between Australia and the EU, insisting he had not made any criticism of Brussels over its handling of the matter.

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Patients in Wales to be first in UK to receive Moderna Covid vaccine

Nation’s mass rollout begins on Wednesday, while Scotland will administer first doses later this week

Patients in Wales will from Wednesday become the first in the UK to receive the Moderna vaccine as part of a mass vaccination programme, with the first doses in Scotland set to come later this week.

The initial jabs would be given at the West Wales general hospital in Carmarthen, the Welsh government said.

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AstraZeneca Covid vaccine: weighing up the risks and rewards

Despite scientific advice to continue getting the jab, answers about fatal blood clots are urgently needed

Vaccines have side-effects, as do all medicines. Most often, jabs cause sore arms, a headache or a bit of nausea – none of which would be very significant when weighed against the toll of a serious virus such as Covid-19.

But sometimes the risk-benefit calculation may look less simple, as in the case of Oxford/AstraZeneca’s Covid jab and cerebral venous sinus thrombosis (CVST), the blood clots in the brain that have led to fatalities in the UK and Europe.

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Israel and Chile both led on Covid jabs, so why is one back in lockdown?

Analysis: contrasting national outcomes highlight how easily UK could blow its chances

As mass vaccination programmes take hold around the world, some countries have begun to get on top of the virus while others have continued to struggle. Two countries that have streaked ahead with immunisations are Israel and Chile, but as Israel edges back to a new normal, Chile has been plunged back into lockdown. Can the UK and other countries repeat Israel’s success and avoid the setbacks of Chile?

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EU drug agency denies already finding causal link between AstraZeneca vaccine and blood clots

European Medicines Agency says review ongoing after head of vaccines spoke of ‘clear’ association

Europe’s drug regulator has denied it has already established a causal connection between the Oxford/AstraZeneca vaccine and a rare blood clotting syndrome, after a senior official from the agency said there was a link.

In a statement to Agence France-Presse, the European Medicines Agency (EMA) said on Tuesday it had “not yet reached a conclusion and the review is currently ongoing”, adding that it expected to announce its findings on Wednesday or Thursday.

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UK Covid passports – who’s for and who’s against?

Labour leftwingers and Tory libertarians oppose them, while Keir Starmer’s position appears flexible

One of the most significant political controversies of the coronavirus period is likely to be over the idea of Covid “passports” – app-based, biometric certificates that would allow people entry to potentially crowded spaces. While they are sometimes referred to as “vaccine passports”, these would not just show vaccination status. Other ways people could prove they were safe to mingle would be a sufficiently recent test showing significant Covid antibodies, or a very recent negative test for the virus.

These are distinct from the idea of a proof of vaccination to be allowed to enter overseas countries, which is less contentious.

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A year on, Keir Starmer’s grand vision is still in question | Letters

Dr Anthony Isaacs thinks the Labour leader must unite the party and restore the whip to Jeremy Corbyn, but Bruce Sawford has lost hope

No new opposition leader could have been expected to gain much media attention in their first year against the backdrop of the Covid-19 pandemic, and the government has clearly benefited from the vaccine rollout. But after a promising start, Keir Starmer’s declining poll ratings (Keir Starmer: one year in, Labour leader’s popularity has plunged, 2 April) indicate that his cautious style and lack of defined policies have failed to gain traction. The pandemic has, paradoxically, opened the way to an alternative agenda that plays to Labour’s strengths of promoting social solidarity and investment in public services. Starmer must embrace the opportunity of the waning infection rates to move the fight away from equivocation and abstention over Tory culture wars to ground of Labour’s own choosing.

Your editorial (2 April) points to Labour’s need for a transformative agenda that both rallies the party and speaks to the wider public. To bring this about, Starmer must first unite the party. Restoring the whip to Jeremy Corbyn would be an important symbolic gesture, opening the way for the party’s factions to work together in devising popular policies to combat the corruption and market failures epitomised by our current government. The second task is to unite opposition parties around an electoral strategy as the only hope of preventing continued Tory dominance. That will be a true test of leadership.
Dr Anthony Isaacs
London

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Brazil records 70,238 new cases; Netherlands halts AstraZeneca jab for under 60s – as it happened

Country has registered more than 12.9 million cases; 10,000 appointments scrapped, reports Dutch news agency citing Netherlands health ministry

That’s it from the global blog team for now. Thanks for following our coverage, a new blog will be going live in a few hours.

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Seven UK recipients of Oxford jab reported dead after clotting

Experts say numbers of rare blood clots remain low and benefits of Covid vaccine far outweigh risks

Further cases of a rare blood clotting syndrome including seven deaths have been reported among recipients of the Oxford/AstraZeneca jab in the UK, although experts say the numbers remain low and the benefits of the vaccine far outweigh any risks.

The Medicines and Healthcare products Regulatory Agency (MHRA), runs a “yellow card” scheme to pick up suspected side-effects or other concerns for medicines and medical devices.

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‘We’re in a really good place’: is Israel nearing the Covid endgame?

Vaccination centres are winding down and infections continue to fall as country reopens

At the peak of Israel’s Covid vaccination drive, the halls of a huge basketball arena in Jerusalem were filled with people, each anxiously waiting up to two hours until their number was called. More than 3,000 people a day were being vaccinated here in January.

On Monday, no more than 15 people lingered around long rows of empty chairs. Some barely had time to sit down before they were called to receive a jab. “They wait about 10 seconds,” said Shani Luvaton, the head nurse at the vaccination centre. She only uses half her booths for just a few hundred people a day.

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Pfizer vaccine has 91% efficacy for up to six months, trial shows

Findings based on two doses three weeks apart are first to show shot remains effective for many months

The coronavirus vaccine developed by Pfizer and its German partner BioNTech protects against symptomatic Covid for up to six months, an updated analysis of clinical trial data has found.

In a statement released on Thursday, the companies reported efficacy of 91.3% against any symptoms of the disease in participants assessed up to six months after their second shot. The level of protection is only marginally lower than the 95% achieved soon after vaccination.

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Dire situation in North Korea drives ‘collective exit’ of diplomats

Russian embassy staff cite medicine shortages and unbearable conditions arising from strict Covid restrictions

Russian diplomats fleeing North Korea have described acute shortages of medicines and other basic goods in the country, indicating a crisis fuelled by one of the world’s strictest quarantine regimes amid the coronavirus pandemic.

In a letter posted online on Thursday, employees of the Russian embassy in Pyongyang described a “collective exit” of foreign diplomatic staff that they predicted would “unfortunately not be the last” due to unbearable conditions in the North Korean capital.

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