‘There are many roadblocks’: Fears grow over US Covid-19 vaccine rollout

States will soon begin distributing a vaccine with plans that vary widely, lack federal funding and are often opaque

Eleven hospitals in Kentucky will receive doses of a Covid-19 vaccine developed by Pfizer, perhaps as soon as Monday. Dr Nichelle Jadhav’s hospital is not one of them and she is confused. And she is not alone.

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Has a year of living with Covid-19 rewired our brains?

The pandemic is expected to precipitate a mental health crisis, but perhaps also a chance to approach life with new clarity

When the bubonic plague spread through England in the 17th century, Sir Isaac Newton fled Cambridge where he was studying for the safety of his family home in Lincolnshire. The Newtons did not live in a cramped apartment; they enjoyed a large garden with many fruit trees. In these uncertain times, out of step with ordinary life, his mind roamed free of routines and social distractions. And it was in this context that a single apple falling from a tree struck him as more intriguing than any of the apples he had previously seen fall. Gravity was a gift of the plague. So, how is this pandemic going for you?

In different ways, this is likely a question we are all asking ourselves. Whether you have experienced illness, relocated, lost a loved one or a job, got a kitten or got divorced, eaten more or exercised more, spent longer showering each morning or reached every day for the same clothes, it is an inescapable truth that the pandemic alters us all. But how? And when will we have answers to these questions – because surely there will be a time when we can scan our personal balance sheets and see in the credit column something more than grey hairs, a thicker waist and a kitten? (Actually, the kitten is pretty rewarding.) What might be the psychological impact of living through a pandemic? Will it change us for ever?

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George Clooney: ‘It’s been a crappy year, but we will come out of it better’

Marriage and fatherhood have given George Clooney a new perspective on life, work and the world we all share. While his young twins play outside, he talks about outsmarting war criminals, battles with Boris and dinnertime debates with Amal

Dad-chat with George Clooney, father of two. While the actor’s twin three-year-olds, Ella and Alexander, are out on the family tennis court, learning to ride their bikes, Clooney sits in a curtained edit suite inside his Los Angeles home, wondering how they’re getting on out there. “They’ve learned how to get going fast,” says the 59-year-old who, unless otherwise specified, speaks at all times in the measured, half-ironic, woodsmoked tones of just about every leading man he’s played in a quarter-century career. “They just haven’t learned to use their brakes yet.”

Clooney rubs at his two-day beard, anxious, fond. He wears a fawn-coloured polo shirt and he has his grey hair cropped short. I think I notice that slightly wild-eyed look of someone still marvelling at the fact of their parenthood, and I ask him, is he a scaredy-cat dad, always trailing behind his children with his arms outstretched in case they fall? Or is he a let-them-fall-to-learn-about-the-hard-truths-of-the-world sort of dad?

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Scotch eggs: 10-fold surge in demand for ‘substantial meal’

The snacks were deemed by ministers last week to be sufficient to order alongside alcohol in tier 2-area pubs

Suppliers of scotch eggs have reported a surge in demand after ministers said they classed as a “substantial meal”, thereby allowing people to order alcohol alongside them in pubs.

The food wholesaler Brakes, which works with 50,000 pubs across the UK, has seen a 10-fold increase in demand for the pork and breadcrumb-covered eggs since the lockdown in England ended last week.

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This year, for the first time, I won’t go home for Christmas. Will my family ties loosen for good?

Flying visits to Northern Ireland kept me connected. FaceTime, Zoom and my niece’s drawings arriving by post are no substitute

I have never missed Christmas at home, though I have lived elsewhere for more than 20 years. This year, I will break that run. The festive travel window means that I could fly back to Northern Ireland from London. But my father is elderly and our neighbourhood on the border has been relatively untouched by Covid-19 until recently, so it doesn’t feel the safest plan. Instead, I’ll be in London. It will mark a year since I’ve been home; the longest I’ve ever been away.

With a flight time of under an hour, on a ticket often cheaper than a night out, I normally go home many times a year. It means I never have to miss a big night out; if it’s an emergency, I can be back in a matter of hours. Being home often feels crucial to my sense of self.

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Origin story: what do we know now about where coronavirus came from?

When Chinese scientists alerted colleagues to a new virus last December, suspicion fell on a Wuhan market. What have health officials learned since then?

Maria van Kerkhove was staying with her sister in the US for the Christmas holidays, but checking her emails. As always. Every day there are signals of potential trouble, said the World Health Organization virologist who was to become a household name and face within weeks.

“There’s always something that happens at Christmas time. There’s always some alert, or a signal of a suspected case. The last several years it’s been Mers [Middle East respiratory syndrome] – a suspect case travelling to Malaysia or Indonesia or Korea or somewhere in Asia from the Middle East. So there’s always some kind of signal. There’s always something that happens,” she said.

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‘Covid-19 has an odour, and the dogs are detecting it’: meet the canine super-squad sniffing out the virus

They’re loyal, diligent – and have unbeatable noses. Could dogs play a key part in the fight against the pandemic?

A single-storey building in a lonely rural business park, a few miles from Milton Keynes on a grey autumn day. It looks like a location for a bleak thriller: where a kidnap victim is held, perhaps, or the scene of a final shootout. Inside, though, something kind of cool is happening.

In a brightly lit room, four inverted metal cups have been placed on the red carpet, each containing a small glass jar. One of these contains a smell: a “training odour”. Into the room bursts Billy, followed by Jess. Billy is a labrador, and Jess his human trainer. Billy bounces about the place, clearly super excited. He sniffs at everything – furniture, people, the cups – wagging ferociously. When he sniffs at the cup that contains the smell, another trainer, Jayde, indicates success with a clicking noise. Billy is rewarded with his favourite toy, a well-chewed rubber ball, and a chorus of “good boy”.

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Coronavirus live news: US vaccinations to begin ‘in 24 hours’ after FDA approves Pfizer jab

Trump hails rollout of immunisation program; UK coronavirus hospitalisations increase; WHO warns number of deaths surging

Germany has recorded 28,438 new Covid-19 cases in the past 24 hours, taking the total in the country to 1,300,516, according to the Robert Koch Institute for infectious diseases.

An additional 496 people died from the virus, taking the total death toll to 21,466.

In Australia, parts of New South Wales and Queensland are on flood watch as heavy rains continue.

Overnight, Coffs Harbour received 180mm in less than 24 hours and Bowraville got 195mm.

Related: Australia storms: NSW flood warnings as torrential rain to hit south-east Queensland

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Coronavirus live news: Italy overtakes UK for European highest death toll; Germany to close shops as part of tougher restrictions

Trump hails start of immunisation programme; UK coronavirus hospitalisations increase; WHO warns number of deaths surging

Here the latest developments at a glance:

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Oxford Covid vaccine to be combined with Sputnik jab for trial

UK and Russian scientists to explore whether vaccines given together improves efficacy

UK and Russian scientists are to test whether combining shots of the Oxford/AstraZeneca and Sputnik V coronavirus vaccines could result in better protection than two doses of the same one.

Trials will start by the end of the year, the Russian Direct Investment Fund (RDIF), which funded the development of the Sputnik V vaccine by Russia’s Gamaleya Institute, said on Friday. AstraZeneca confirmed that it was considering how it could assess combinations of different vaccines, and would soon begin exploring with the Gamaleya Institute whether their two vaccines could be successfully combined.

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South Africa’s chief justice unrepentant for linking Covid vaccines to satanism

Concerns surface that people might avoid having jabs as result of comments by Mogoeng Mogoeng

South Africa’s chief justice has dismissed concerns that he may be endangering people’s health by linking coronavirus vaccines to a “satanic agenda”.

The comment by Mogoeng Mogoeng marked the first time since the outbreak of the pandemic that a senior judge had aired such preoccupations.

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Brexit: Ursula von der Leyen says EU trade deal proposals would not undermine UK sovereignty – live

Latest updates: Von der Leyen says two sides remain apart and UK must accept fair competition as pre-condition for access to single market

Simon Coveney, the Irish foreign minister, has urged politicians involved in the UK-EU trade negotiations to “dial down the language”. In comments which seemed to be aimed at Boris Johnson, Coveney told reporters at a press conference in Berlin:

What I would say to politicians, we need to try and dial down the language in terms of the division and differences of views and focus on the detail.

There is a bigger picture here that goes beyond trade in a world that is changing and has a lot of risk.

The Conservative MP Imran Ahmad Khan has criticised Angela Merkel for refusing to let Boris Johnson lobby her over the UK-EU trade talks. (See 10.57am and 12.37pm.) You can tell Ahmad Khan’s a Brexiter, because he’s brought up the war ...

I stand with millions of Britons that are deeply insulted at the shocking news that the German Chancellor has refused the British Prime Minister’s request for a telephone call. This is an insult to every Briton, whether they support our PM or not.

Have our EU “friends” no regard or respect for the UK and our nations’ sacrifices that permit them to live in freedom and prosperity today, safely away from the shadow of totalitarianism?

The EU’s contemptuous treatment of the UK makes it clear there cannot be a deal until it accepts the UK as a sovereign equal and awards us the respect and regard we merit.

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The magnifying glass: how Covid revealed the truth about our world

The pandemic has illuminated deprivation, inequalities and political unrest, while reminding us of the power and beauty of nature and humanity

What might be the enduring symbol of the coronavirus that turned our world upside down in 2020? Might it be those Thursday evenings of spring and summer when, at the stroke of 8pm, Britons overcame the national traits of embarrassment and reserve and ventured out on to the doorstep to applaud doctors, nurses and key workers, banging saucepans and nodding to neighbours in a synchronised “clap for carers”? Or might it be the first sign that trouble was coming this way, that footage of Italians singing to each other from their balconies in a ritual that seemed as exotic, distant and unlikely then as the very notion of a “lockdown”, back before that dramatically punitive word lost its sting?

A chequerboard computer screen of faces as Zoom became the prime means of face-to-face contact with those who didn’t live under one roof? The smaller, quieter sight of families visiting grandparents but getting no further than the garden path, toddlers waving through the glass at elderly relatives?

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Coronavirus live news: infections down in England – but not London; 7pm curfew introduced in Switzerland

London bucks trend of declining positive tests in England; Switzerland orders restaurants, bars and shops to close down from 7pm

Companies in America are considering various options to get employees back to work after the Covid vaccine has been rolled out, Reuters is reporting.

Options on the table include giving workers a choice between a free vaccine and a cash bonus if everyone gets inoculated, to being reassigned or even losing your job.

Australia has cancelled the production of a locally made vaccine against Covid-19 after trials showed it could interfere with HIV diagnosis, Reuters is reporting.

The government has instead securing additional doses of rival vaccines.

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First US Covid vaccinations expected next week as FDA emergency approval appears close – live

Dr Anthony Fauci has issued what journalists like to call a “reality check” ahead of a vaccine potentially being rolled out next week.

“If we have a smooth vaccination program where everybody steps to the plate quickly, we could get back to some form of normality, reasonably quickly.

The term #trumpconceded is now trending on Twitter, after the president’s earlier tweet about “the Biden Administration”:

Now that the Biden Administration will be a scandal plagued mess for years to come, it is much easier for the Supreme Court of the United States to follow the Constitution and do what everybody knows has to be done. They must show great Courage & Wisdom. Save the USA!!!

He only won in the eyes of the FAKE NEWS MEDIA. I concede NOTHING! We have a long way to go. This was a RIGGED ELECTION!

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Germany heads for national lockdown as Covid cases rise sharply

Experts warn that delaying measures until after Christmas could cost tens of thousands of lives

Germany is heading for a major new nationwide lockdown to stem the rapid spread of the coronavirus after health experts said that to wait until after Christmas to wind the country down could cost tens of thousands of lives and overwhelm hospitals.

The country recorded almost 23,000 new cases on Wednesday morning, and 598 deaths, both rates higher than at any time since the start of the pandemic.

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Hangovers, heartaches, horrible meetings: why we all need ‘work wives’

If you started a new job in 2020, or began working from home, you’re missing out on more than the Christmas party. Here’s why office friendships matter

You never forget your first. I met Abi in early 2009 when we were assistants on a fashion magazine. We sized each other up like a pair of cats on a suburban lawn, then quickly became inseparable. She: Mancunian, funny and forthright. Me: in her words, “Quite posh, aren’t you?”

We were on the bottom rung of a monthly publication that specialised in celebrities and style. It would be fair to say we were not great experts in either field. One aspect of the job involved going to parties to get quotes from famous people. At one, we attempted to interview a pop star, only for our confused interviewee to tell us she was in fact a makeup artist.

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WHO accused of conspiring with Italy to remove damning Covid report

Exclusive: document intended to help prevent future deaths allegedly pulled from website after request

The World Health Organization has been accused of conspiring with the Italian health ministry to remove a report revealing the country’s mismanagement at the beginning of the coronavirus pandemic – the publication of which was intended to prevent future deaths.

Italy was the first European country to become engulfed by the pandemic. The report, produced by the WHO scientist Francesco Zambon and 10 colleagues across Europe, was funded by Kuwait’s government with the objective of providing information to countries yet to be hit.

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