What does the Moderna vaccine mean for the fight against Covid?

How does it work and how is it different from the Pfizer/BioNTech jab?

As promising results are released from a second vaccine trial, we take a look at what this could mean in the battle against Covid-19.

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Joker ‘a betrayal’ of mentally ill people, says David Fincher

Mank director rails at the risk-averse production strategy of major Hollywood studios

Mank director David Fincher has described Todd Phillips’ Oscar-winning Joker as “a betrayal” of mentally ill people.

In an interview with the Daily Telegraph, Fincher was reflecting on Joker’s surprise success at the box office in a wide-ranging attack on the risk-averse production strategy of the major Hollywood studios. Saying that studios “don’t want to make anything that can’t make them a billion dollars”, he also suggested that occasionally “challenging” material can get support, if there is solid previous evidence of commercial potential.

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Video gaming can benefit mental health, find Oxford academics

Research based on playing time data showed gamers reported greater wellbeing

Playing video games can be good for your mental health, a study from Oxford University has suggested, following a breakthrough collaboration in which academics at the university worked with actual gameplay data for the first time.

The study, which focused on players of Nintendo’s springtime craze Animal Crossing, as well as EA’s shooter Plants vs. Zombies: Battle for Neighborville, found that people who played more games tended to report greater “wellbeing”, casting further doubt on reports that video gaming can harm mental health.

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Roddy Evans obituary

My friend, Roddy Evans, who has died aged 97, was a skilled surgeon and a remarkable man, whose commitment to his worldwide community was highly significant.

A Christian, he was drawn to the Moral Re-Armament movement (MRA, now Initiatives of Change) because it was based on practical Christianity: putting your own life in order first so that you can help others. Roddy lived a simple life and he believed that God would provide for him.

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‘Find a part of each day to relish’: coping with cancer and Covid

This year has challenged us all. But for Sarah Hughes it’s been particularly hard. Here, she talks about living with cancer – and letting in the light in the darkest of times

The strangest thing about having an incurable illness during a time of pandemic is the weird but unavoidable sense that everyone has finally caught up with you. As people started talking about how worried they were, how they couldn’t stop thinking about the virus, how difficult life now seemed, how isolated, the temptation to say: “Hey guys, welcome to my world” was overwhelming.

This had never felt more pertinent than last month, when social media lit up with Breast Cancer Awareness memes and pink ribbons and talk of fighting and beating the disease. For those of us with stage IV cancer such messages seem beamed in from another planet. As the campaign group MetUpUK points out, 31 people die every day from metastatic breast cancer, and countless more of us live each day with a disease that has a median survival rate of two to three years – a rate that drops considerably if you have a cancer that began as a triple negative breast cancer, as mine did. Yet our stories, which might force people to face the uncomfortable truth that we are not “winning” the “fight”, are rarely told.

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Cannabis resin now 25% more potent, global study reveals

Concentrations of intoxicating THC have risen, data from more than 80,000 street drug samples gathered over 50 years shows

Cannabis resin – or “hash” – has increased in strength by nearly 25% over the past half century, a major international study has revealed.

Researchers with the Addiction and Mental Health Group at the University of Bath analysed data from more than 80,000 cannabis street samples tested in the past 50 years in the US, UK, Netherlands, France, Denmark, Italy and New Zealand.

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Is the vaccine safe? Do I need it if I’ve had Covid? Readers’ questions answered

‘Zero chance’ mRNA can alter genes, says expert, adding that vaccine can ‘top up’ immune response from infection

“The concerted efforts put into developing a vaccine are wonderful but they can’t possibly know about long-term adverse effects. I’ll have it if it’s offered to me, and at my age long-term effects are irrelevant. I just hope it doesn’t turn out to be a latter-day thalidomide.” Jenny Walters, retired teacher, Ashburton

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Viral video of ballerina with Alzheimer’s shows vital role of music in memory

Music’s primal power for those living with dementia has inspired thousands of YouTube views for a clip of a former dancer

We see a frail and elderly woman in a chair, her eyes downcast. She motions for the music to be turned up, a swelling melody from Tchaikovsky’s Swan Lake, and with a little encouragement her hands begin to flutter. Then suddenly her eyes flash and she’s Odette the swan queen at the misty lakeside, arms raised. She leans forward, wrists crossed in classic swan pose; her chin lifts as if she’s commanding the stage once more, her face lost in reverie.

The woman in the film is Marta Cinta González Saldaña, a former ballet dancer who died in 2019, the year the video was shot. But the clip has gone viral since being posted recently by Spanish organisation Música Para Despertar (Music to Awaken), which promotes the value of music for those living with Alzheimer’s. Many of the details accompanying the video on its journey around the internet have been erroneous. Marta Cinta was not a member of the “New York Ballet” (there’s no such company) or the actual New York City Ballet, but seems to have run her own dance company in the city; the ballerina performing in the intercut video is not her but Ulyana Lopatkina, who is not even dancing Swan Lake but Mikhail Fokine’s The Dying Swan. Yet none of that takes away the impact of watching someone seemingly light up and have their memories unlocked by the power of melody. It’s as if you’re seeing Saldaña inhabit her true self.

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Measles cases hit 20-year high as Covid disrupts vaccinations, report finds

Number of people dying from the disease also increased by 50% since 2016, according to data from the WHO and CDC

The number of measles cases worldwide surged to nearly 900,000 in 2019, the highest figure in more than two decades, underlining a significant U-turn in global progress to combat the disease.

Data from the World Health Organization (WHO) and US Centers for Disease Control and Prevention (CDC) found that the number of people dying from measles also increased by 50% since 2016, with an estimated 207,500 deaths in 2019 alone.

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National cabinet endorses national vaccination policy – as it happened

PM and premiers meet as Covid-19 cases plummet. This blog is now closed

The day is winding down so we are going to wrap up the blog. Here are the main events:

The rise of rightwing extremism has coincided with the emergence of social media “echo chambers” and easily formed online communities of interest, the head of home affairs has said.

Michael Pezzullo, the secretary of the department, appeared before a parliamentary hearing into social cohesion and nationhood this afternoon.

He was asked about recent testimony from the head of Asio that rightwing extremism now made up 30% to 40% of its priority counter-terrorism investigations. Labor committee chair Kim Carr wanted to know whether Pezzullo thought the trend coincided with the rise or rightwing populist groups in the US and Europe.

Domestically it would seem to me that the groups that are of most concern are those that would either promote or seek others to adhere to a philosophy or an ideology of extra-constitutional action, and worse of course extremist action, and worst of all violent action rather than moderating legitimately held differences of political, ideological, economic views through our democratic process.

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Scientist behind BioNTech/Pfizer vaccine says it can end pandemic

Exclusive: BioNTech’s CEO Uğur Şahin says he is confident vaccine can ‘bash the virus over the head’

The scientist behind the first Covid-19 vaccine to clear interim clinical trials says he is confident his product can “bash the virus over the head” and put an end to the pandemic that has held the world hostage in 2020.

The German company BioNTech and the US pharmaceutical giant Pfizer announced via a press release on Monday that their jointly developed vaccine candidate had outperformed expectations in the crucial phase 3 trials, proving 90% effective in stopping people from falling ill.

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Alcoholic anaesthetist jailed for killing Briton during caesarean birth in France

Helga Wauters imprisoned for three years and banned from practising after death of Xynthia Hawke

An alcoholic anaesthetist who botched an emergency caesarean operation leaving a young British mother dead has been sentenced to three years in prison and banned from practising medicine.

Helga Wauters, 51, was found guilty of manslaughter after pushing a breathing tube into 28-year-old Xynthia Hawke’s oesophagus instead of her windpipe. Even after Hawke cried out in pain, vomited, turned blue and went into cardiac arrest, the anaesthetist, who admitted she had an alcohol problem and had been drinking since early morning on the day of the operation, failed to react.

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French professor faces disciplinary case over hydroxychloroquine claims

Didier Raoult stands accused of touting drug as a coronavirus treatment without evidence

A French professor who touts the anti-malaria drug hydroxychloroquine as a coronavirus treatment – without evidence, scientists say – will appear before a disciplinary panel charged with ethics breaches, an order of doctors has said.

Marseille-based Didier Raoult stands accused by his peers of spreading false information about the benefits of the drug. His promotion of hydroxychloroquine was taken up by the US and Brazilian presidents, Donald Trump and Jair Bolsonaro, who trumpeted its unproven benefits in a way critics say put people’s lives at risk.

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Spike in yellow fever deaths prompts Nigeria to revive vaccination campaigns

Resurgence of disease linked to factors including climate crisis and focus of health resources on Covid response

More than 70 people are feared to have died of yellow fever in Nigeria since September, as health authorities warn of a resurgence of the disease.

The country recorded 47 deaths from yellow fever throughout the whole of 2019.

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Totnes Covid concerns reflect UK-wide rise in conspiracy theories

Suspicion in Devon town of face masks and 5G means take-up of vaccine may face resistance

Like many people living in or around Totnes in Devon, David, who is in his 70s, has his own theories about coronavirus and its origins. Sitting in the armchair of his house, he says the pandemic is a secret plot to impose a totalitarian world government and a nefarious effort to crush freedom. He scrolls through Facebook, which he recently signed up to, to show many with similar beliefs.

David came to many of these ideas recently. When the pandemic hit, he started looking for answers. “I’m friends with a few people who are active in researching what is going on. I quickly made contact with others putting posts on the internet.”

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6 key questions about the Pfizer/BioNTech Covid-19 vaccine

There are grounds for optimism but also several unknowns around this coronavirus vaccine

Hopes that the end of the coronavirus pandemic has become nearer have soared after the news that a coronavirus vaccine was found to be 90% effective in global trials.

Although there is definite reason to be optimistic, experts have cautioned that the data from the trials conducted by Pfizer and BioNTech are not final, and there remain plenty of unknowns.

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Nearly one in five Covid patients later diagnosed with mental illness – study

US data shows nearly twice as many diagnoses over three months among those testing positive

Nearly one in five people who have had Covid-19 are diagnosed with a psychiatric disorder such as anxiety, depression or insomnia within three months of testing positive for the virus, according to a study that suggests action is needed to mitigate the mental health toll of the pandemic.

The analysis – conducted by researchers from the University of Oxford and NIHR Oxford Health Biomedical Research Centre – also found that people with a pre-existing mental health diagnosis were 65% more likely to be diagnosed with Covid-19 than those without, even accounting for known risk factors such as age, sex, race, and underlying physical conditions.

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Hopes rise for end of pandemic as Pfizer says vaccine is 90% effective

Global stocks surge and experts optimistic as Covid vaccine exceeds expectations

Hopes are soaring that a Covid vaccine is within reach, following news that an interim analysis has shown Pfizer/BioNTech’s candidate was 90% effective in protecting people from transmission of the virus in global trials.

The vaccine performed much better than most experts had hoped for, according to the companies’ analysis, and brings into view a potential end to a pandemic that has killed more than a million people, battered economies and upended daily life worldwide.

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Pfizer/BioNTech vaccine announcement is cause for cautious celebration

Interim trial results are encouraging as scientists welcome news

It is not yet the end of the pandemic, but the announcement by Pfizer/BioNTech that their vaccine has been 90% successful in the vital large-scale trials has got even the soberest of scientists excited.

These are interim results and the trial will continue into December to collect more data. The two companies – a tiny German biotech with the big idea and the giant pharma company Pfizer with the means to develop it – have not yet published their detailed data, so it is all on trust. And yet, nobody is suggesting the results have been over-egged. It looks as though the vaccine not only works, but works better than anyone hoped.

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Global report: new Covid lockdown in Hungary as Belgium passes second peak

Portugal imposes state of emergency; global cases pass 50m; infections in Germany ‘levelling off’

Hungary and Portugal have become the latest countries in Europe to impose tough new restrictions to stem the second wave of the coronavirus, as the first signs of light at the end of the tunnel emerged in France, Germany and Belgium.

As the US pharmaceuticals company Pfizer and its German partner, BioNTech, said their experimental Covid-19 vaccine appeared safe and more than 90% effective, Hungary’s prime minister, Viktor Orbán, announced a partial lockdown.

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