Austria says easing lockdown has not led to spike in infections; Macron says major foreign travel will be limited this summer; global deaths pass 250,000

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9.33pm BST

The US Centers for Disease Control and Prevention (CDC) has reported 19,138 new confirmed cases; taking the total to at least 1,171,510. The number of deaths has risen by 823 to 68,279, it added.

The figures do not necessarily reflect those reported by individual states.

9.27pm BST

A regional capital in Brazil has become the country’s first city to declare a total lockdown – in direct opposition to the president Jair Bolsonaro, who has railed against social isolation and dismissed a soaring death-toll.

The lockdown in São Luís, capital of the north-estern state of Maranhão, and three neighbouring towns, was ordered by a judge after intensive care beds in state government hospitals filled up. States such as Rio de Janeiro are watching closely. But the move came as looser social isolation measures introduced by state governors crumble across Brazil and cases soar.

Schools in Turkey to stay shut until end of May; Germans urged to stay home; Vietnam says it has had no domestic transmission for two weeks

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9.51pm BST

Another 31 people have died in Ireland and 376 more cases have been diagnosed, the country’s chief medical officer Dr Tony Holohan has said.

One of the deaths reported on Wednesday involved a person in the 15-24 age group, the second in this category. Dr Holohan warned the number in intensive care units was too high as the prospect of a rapid easing of movement restrictions dwindles.

That is simply too high and we need to get that down further not only because it is about protecting occupancy but the lower the figure is it is a reflection of better protection of the public and lower levels of spread of the infection.

9.26pm BST

Bolivia will extend its lockdown against the pandemic until 10 May, the government has announced, though it is planning to relax rules in less affected parts of the country from the following day.

The president Jeanine Áñez has said Bolivia will move to a “dynamic” or “less rigid” quarantine on 11 May, allowing some people to return to work.

Opening the quarantine a little or closing it completely will depend on how the pandemic is being controlled in each region. The Ministry of Health will evaluate every seven days how the pandemic evolves in each region. On that basis, decisions will be taken to relax or harden the quarantine.