WHO looks at giving Covid-19 to healthy people to speed up vaccine trials

Advisory meeting will discuss feasibility of human challenge trials despite first jabs becoming available

The World Health Organization is holding discussions on Monday about the feasibility of trials in which healthy young volunteers are deliberately infected with coronavirus to hasten vaccine development – amid questions over whether they should go ahead given the promising data from the frontrunner vaccine candidates.

Some scientists have reservations about exposing volunteers to a virus for which there is no cure, although there are treatments that can help patients. However, proponents argue that the risks of Covid-19 to the young and healthy are minimal, and the benefits to society are high.

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Covid deepens south and north of England inequalities, study finds

IPPR North report reveals few signs of government’s levelling up agenda becoming reality

Covid-19 has deepened inequalities between the north and south of England, with little sign of the government’s “levelling up” agenda becoming a reality, a thinktank has warned, in an urgent “wake-up call” to Boris Johnson.

The north is experiencing levels of unemployment not seen since 1994, with areas put under the strictest tier 3 restrictions among the worst affected, IPPR North said in its annual health-check of the economy of the north of England.

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WW1 trench fever identified in former homeless man in Canada

Discovery of wartime disease transmitted by lice prompts calls for more to be done for vulnerable

A disease transmitted by body lice that plagued soldiers during the first world war has been identified in a former homeless man in Canada, prompting calls for more to be done to improve conditions for vulnerable people.

Trench fever is caused by the bacterium Bartonella quintana and is spread by the faeces of body lice. The condition became rife among armies and is thought to have affected more than a million troops during the 1914-18 conflict.

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Jerrold Post, CIA psychiatrist who profiled Trump, dies of Covid aged 86

  • Family salutes ‘insatiable, roving curiosity, probing empathy’
  • Pioneer in field predicted Trump would not concede defeat

Jerrold M Post, a psychiatrist who profiled dictators for the CIA and who declared Donald Trump a “dangerous, destructive charismatic leader”, has died of Covid-19. He was 86.

Related: 'Saddam, tell me about your mum'

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Murder in Mexico: journalists caught in the crosshairs

The 2012 killing of Regina Martínez, who was investigating links between organised crime and politics, began a wave of violence in the most dangerous country to be a reporter

Regina Martínez Pérez was considered an enemy of the state. The 48-year-old journalist had made powerful foes investigating allegations of collusion between political leaders, security forces and narcotraffickers in the Mexican region of Veracruz.

She was a source of irritation for four consecutive state governors, highlighting violence, abuses of power and cover-ups in the pages of Mexico’s foremost investigative news magazine, Proceso.

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Only music reached my wife after dementia hit, says John Suchet

Ex-ITN presenter tells how Abba transformed Bonnie Suchet as study reveals most carers are unaware of the benefits of music

When John Suchet discovered the effect that music had on his wife Bonnie’s dementia, it was transformational. “She would close her eyes and love it, beat in time to the music with her hands, tap her feet,” he said.

The former ITN newscaster’s wife had lost her ability to speak. She had been locked inside her head, sitting blankly, apparently unable to make sense of the outside world.

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The tactics retailers use to make us spend more – and how they harm the vulnerable

Online stores draw in shoppers but those with mental health issues are particularly susceptible

As a digital marketer, Emily Ware spends a lot of time online, yet this comes with a risk. Ware has borderline personality disorder, a mental health condition linked with impulsive behaviours. In her case, that’s spending money online.

“At the start of 2020 I was £4,250 in debt with nothing to show for it,” she says. “A good 95% of this was due to impulse spending, from clothes to pub trips to gig tickets. One of the worst was spending £300 on tickets to see Cher on a whim.”

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Team behind Oxford Covid jab start final stage of malaria vaccine trials

Vaccine could be in use by 2024 if next year’s human trials are successful

The Oxford team that has produced a successful coronavirus vaccine is about to enter the final stage of human trials in its quest for an inoculation against malaria.

The Jenner Institute director, Prof Adrian Hill, said the malaria vaccine would be tested on 4,800 children in Africa next year after early trials yielded promising results.

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‘Women feel they have no option but to give birth alone’: the rise of freebirthing

As Covid infections rose, hospital felt like an increasingly dangerous place to have a baby. But is labouring without midwives or doctors the answer?

On the morning of 3 May, Victoria Johnson prepared to give birth at her home in the Highlands. One by one, her three children came downstairs to where she was labouring in a birthing pool surrounded by fairy lights, the curtains tightly shut against the outside world.

Suddenly, she felt an urge to get out of the pool. “I stood up and it felt as if the weight of the universe crashed from my head to my toes.” Her waters broke – “all over the carpet, which wasn’t ideal” – and the baby started to crown. “Everyone was there, including both grandmothers on video call,” she says. “Once the baby was out, my eight-year-old son came over and said, ‘I’m so proud of you.’ And that was everything.”

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Beating the anti-vaxxers: how star power can help squash vaccine myths

Analysis: Vaccine hesitancy is growing, thanks in part to social media misinformation. Time for the Elvis approach?

The statement by the US president-elect, Joe Biden, that he would be happy to be publicly vaccinated against coronavirus to encourage people to follow suit – following similar pledges from Barack Obama, George W Bush and Bill Clinton – highlights a fundamental concern in global health circles.

Vaccine hesitancy – as well as anti-vaccination activism, sometimes promoted by celebrities – is growing. Countries that were once measles-free are seeing new cases due to suspicion over vaccination. Vaccine hesitancy was listed a year ago as one of the World Health Organization’s 10 global health threats to watch, alongside Ebola and the threat of a global influenza pandemic. Coronavirus came instead.

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Help us prevent Covid creating a lost generation of young people | Katharine Viner

Life chances are in danger of being blighted by the pandemic. That’s why young people are at the heart of our charity appeal this year

  • Please donate to our appeal here

In a year of blight, uncertainty and lives interrupted, 21-year-old Aadam Patel’s experience of the pandemic will resonate among many young people and their families: “I have pressed pause on my life,” he told the Guardian in October, “and although I’m dying to resume it, I don’t even know if there’s a play button there any more.”

Getting life back on track during Covid has proved hard for many of us; but for millions of young people it will be a very major challenge. Society’s odds were already stacked against youngsters from economically deprived communities and from Black, Asian and minority ethnic backgrounds; the pandemic has brought those stark inequalities into even sharper focus, whether it is in the job market, around holiday hunger, or access to online schooling.

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‘These images are a crime scene … it’s massive for us to find the child’

The Internet Watch Foundation is seeing a growing number of tipoffs about child abuse. We talk to one analyst about her work

Isobel* has been working throughout lockdown. With her colleagues in the Internet Watch Foundation (IWF) analyst room in Cambridge she has been responding to a rising number of tipoffs from the public that child abuse images are circulating online. The work is gruelling.

“Today I started at 8.30 and I’ll be looking at content all day long: thousands and thousands of images in a day. We analysts come from all sorts of backgrounds. The main thing is your emotional resilience – it’s incredibly important that you can look at this content and then go home and not think about it.”

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‘Deeply dark criminal activity’ drives rise in child abuse images online

The use of webcams and live streaming has led to increased grooming by predators during the coronavirus pandemic

Child abuse experts are warning that an growing trend of children being groomed through webcams and live streaming by predators has led to a sharp rise in the number of abusive images circulating online since the beginning of the pandemic.

Much of this abuse is happening in children’s own homes while their parents or caregivers are in another room, according to the Internet Watch Foundation (IWF), which says it had already dealt with an increased number of reports of online child abuse images this year. September was a record month with 15,000 reports from the public, 5,000 more than the same month in 2019.

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Why a giant fictional penguin could be the cure for millennial burnout

Pengsoo was created for children’s television, yet it became such a sensation with adults that it was named South Korea’s person of the year. Now it’s ready to take over the globe

Growing up in the South Pole, Pengsoo was to his penguin peers what Rudolph was to Santa’s reindeers: an outcast shunned for being different. Bullies latched on to Pengsoo’s towering frame – at nearly 7ft, Pengsoo is almost twice the height of the average emperor penguin – and its large, unblinking eyes.

“The other penguins didn’t play with me because I was too big,” 10-year-old Pengsoo told producers at a studio in the Korea Educational Broadcasting System (EBS) headquarters in Seoul in April 2019. Sitting in a gray room, empty save a too-small chair positioned beside a childish self-portrait, Pengsoo stared at the producers as it spoke. Pengsoo had swum to South Korea from the Antarctic “not too long ago”, it said, in the hopes of becoming the next big sensation on YouTube, which was “getting very popular” in its homeland. But the bullying there had been too much.

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Puberty blockers ruling: curbing trans rights or a victory for common sense?

A highly anticipated judgement on Tuesday concluded children under 16 are unlikely to be mature enough to give informed consent

A landmark high court ruling has focused a spotlight on the work of the Gender Identity Development Service for Children and Adolescents (GIDS) at the Tavistock and Portman NHS trust in London.

The highly anticipated judgment on Tuesday concerned legal action taken by 23-year-old Keira Bell against the service – the only one of its kind for England and Wales.

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‘The scientists have done it’: Boris Johnson hails Covid vaccine

PM says news brings ‘sure and certain knowledge’ that people can reclaim their lives

Boris Johnson has declared that the nation is no longer resting on the hope of a return to normality by spring but instead has the “certain knowledge” that people can reclaim their lives, as he hailed the arrival of the newly approved Covid-19 vaccine.

The prime minister told a Downing Street press conference on Wednesday that “the scientists have done it”, although he stressed that people should not get carried away with “over-optimism”, insisting that they continue to abide by the rules.

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Female trafficking survivors in UK forced into unsafe housing, report finds

Large proportion of victims not placed in specialist safe housing, leaving them vulnerable to further exploitation, says charity

Female trafficking survivors in the UK who have the legal right to be placed in safe housing are being forced to live in “inappropriate and insecure” accommodation where they risk being re-trafficked and exploited, according to a new report.

Anti-trafficking charity Hibiscus Initiatives says that 98% of modern slavery victims referred to it in the past two years were not given specialist safe housing as is their right under UK law, but were instead housed in unsafe asylum accommodation.

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A Girl from Mogadishu review – tragedy and joy in a daring escape

This based-on-fact story of a teenager who flees war in Somalia to become a crusading activist against FGM is earnest but effective drama

Inspired by real events, this earnest but effective drama depicts how Ifrah Ahmed (played as a teenager by Malaika Herrador, and as an adult by Aja Naomi King) escaped Somalia during a war in 2006, made it to Ireland where she was eventually granted asylum, and then went on to become a crusading activist against female genital mutilation. It’s certainly a remarkable story, one full of tragedy, adventure, suspense and even moments of joy, especially in the latter half when Ahmed finds a community of friends and allies willing to help her quest.

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UK approves Pfizer/BioNTech Covid vaccine for rollout next week

‘Historic moment’ allows mass immunisation, with 800,000 doses expected to be available next week

The UK has become the first western country to license a vaccine against Covid, opening the way for mass immunisation with the Pfizer/BioNTech vaccine to begin next week for those most at risk.

The vaccine has been authorised for emergency use by the Medicines and Healthcare products Regulatory Authority (MHRA), before decisions by the US and Europe. The MHRA was given power to approve the vaccine by the government under special regulations before 1 January, when it will become fully responsible for medicines authorisation in the UK after Brexit.

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Elliot Page: star of X-Men and Juno announces he is transgender

Actor takes aim at transphobic politicians and ‘those with a massive platform who continue to spew hostility’, saying they ‘have blood on [their] hands’

Elliot Page, who rose to fame as the lead in teen pregnancy comedy Juno as Ellen Page, has announced he is transgender.

“Hi friends,” he wrote on a variety of social media platforms, “I want to share with you that I am trans, my pronouns are he/they and my name is Elliot.”

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