Ten Republican-led states sue over vaccine mandate for healthcare workers

Lawsuit follows similar ones challenging new Biden administration rules for federal contractors and large businesses

A coalition of 10 states sued the federal government on Wednesday to try to block a Covid-19 vaccine requirement for healthcare workers, marking a new front in the resistance by Republican-led states to the pandemic policies of President Joe Biden’s administration.

The lawsuit filed in a federal court in Missouri contends that the vaccine requirement threatens the jobs of millions of healthcare workers and could “exacerbate an alarming shortage” in healthcare fields, particularly in rural areas where some health workers have been hesitant to get the shots.

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People testing negative for Covid-19 despite exposure may have ‘immune memory’

Study says some individuals clear virus rapidly due to a strong immune response from existing T-cells, meaning tests record negative result

We all know that person who, despite their entire household catching Covid-19, has never tested positive for the disease. Now scientists have found an explanation, showing that a proportion of people experience “abortive infection” in which the virus enters the body but is cleared by the immune system’s T-cells at the earliest stage meaning that PCR and antibody tests record a negative result.

About 15% of healthcare workers who were tracked during the first wave of the pandemic in London, England, appeared to fit this scenario.

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Hesitancy, inequity: is the US ‘making the same mistakes’ with kids’ vaccines?

Only half of children aged 12 and above have been vaccinated, despite vaccine being available for months

When Nia Heard-Garris’s son found out the Covid vaccines were authorized for adults in the US late last year, he was thrilled, then asked, “But what about us? What about kids?”

The eight-year-old is finally signed up for his first shot later this week. Even though he’s afraid of needles, he can’t wait to get vaccinated so he can return to a greater semblance of normal kid life – hanging out with his friends, going to school, playing sports – without worrying about getting sick or bringing the virus home.

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‘He drives me mad!’ Why don’t we dump toxic friends?

According to psychologists, ‘ambivalent’ relationships can cause us more stress than being with people we actively dislike. Is it time to let go – or can these friendships be salvaged?

Roger and Jim have been friends for more than 30 years. When they were younger they were in a band together, and their friendship was forged over a shared love of music and beer. Even now, despite family commitments on both sides, they manage to catch up every couple of months. “Even though he drives me mad,” says Roger.

It is Jim who leaps to Roger’s mind at the mention of toxic friendships. Every time they meet, Roger says, they “tend to have the same conversation”, because Jim never listens to what he says.

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Chinese city offers cash for clues as Covid outbreak declared a ‘people’s war’

Authorities announced the 100,000 yuan ($15,640) rewards for residents in Heihe, saying illegal hunting or crossing the border should be reported

Residents of a Chinese city bordering Russia have been offered major cash rewards for tips on the continuing Delta outbreak, with local officials declaring a “people’s war” on the virus.

Authorities announced the 100,000 yuan ($15,640) rewards for residents in Heihe, in the north-eastern Heilongjiang Province, as its total tally of cases in this outbreak reached 240.

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Covid live: ‘Plan B’ restrictions in UK still possible, government advisor says; sharp rise in German infections

Sage advisor says ‘Plan B’ Covid measures still under consideration in UK; Germany reports 23,543 new cases reported in past 24 hours

Here an update on the global pandemic situation from AFP:

On Saturday, 6,306 new deaths and 411,296 new cases were recorded worldwide.

Based on latest reports, the countries with the most new deaths were Russia with 1,179 new deaths, followed by India with 506 and Ukraine with 449.

Last week, Britain became the first country in the world to approve the potentially game-changing Covid-19 antiviral pill, jointly developed by US-based Merck & Co Inc and Ridgeback Biotherapeutics.

The government said in October it had secured 480,000 courses of the Merck drug, as well as 250,000 courses of an antiviral pill developed by Pfizer Inc.

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Jobs at risk without boost in research investment, peak body warns after Scott Morrison praises scientists

Australia currently spends just 1.8% of GDP on research and development, lagging OECD average

Australia risks losing jobs to other countries if it fails to lift its below-average spending on research and development, a peak science body has warned, amid Scott Morrison’s vow to promote “technology not taxes” on climate policy.

Australia invests just 1.8% of its economic output in research and development, well behind the OECD average of 2.5%.

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Can history teach us anything about the future of war – and peace?

A decade on from psychologist Steven Pinker’s declaration that violence is declining, historians show no sign of agreeing a truce

Ten years ago, the psychologist Steven Pinker published The Better Angels of Our Nature, in which he argued that violence in almost all its forms – including war – was declining. The book was ecstatically received in many quarters, but then came the backlash, which shows no signs of abating. In September, 17 historians published a riposte to Pinker, suitably entitled The Darker Angels of Our Nature, in which they attacked his “fake history” to “debunk the myth of non-violent modernity”. Some may see this as a storm in an intellectual teacup, but the central question – can we learn anything about the future of warfare from the ancient past? – remains an important one.

Pinker thought we could and he supported his claim of a long decline with data stretching thousands of years back into prehistory. But among his critics are those who say that warfare between modern nation states, which are only a few hundred years old, has nothing in common with conflict before that time, and therefore it’s too soon to say if the supposed “long peace” we’ve been enjoying since the end of the second world war is a blip or a sustained trend.

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Will the magic of psychedelics transform psychiatry?

Psychedelics have come a long way since their hallucinogenic hippy heyday. Research shows that they could alleviate PTSD, depression and addiction. So will we all soon be treated with magic mushrooms and MDMA?

Imagine a medicine that could help people process disturbing memories, sparking behavioural changes rather than merely burying and suppressing symptoms and trauma. For the millions suffering with post-traumatic stress disorder (PTSD) and depression, such remedies for their daily struggles could be on the horizon. Psychiatry is rapidly heading towards a new frontier – and it’s all thanks to psychedelics.

In an advanced phase trial published in Nature in May, patients in the US, Israel and Canada who received doses of the psychedelic stimulant MDMA, alongside care from a therapist, were more than twice as likely than the placebo group to no longer have PTSD, for which there is currently no effective treatment, months later. The researchers concluded that the findings, which reflected those of six earlier-stage trials, cemented the treatment as a startlingly successful potential breakthrough therapy. There are now hopes that MDMA therapy could receive approval for certain treatments from US regulators by 2023, or perhaps even earlier – with psilocybin, the active ingredient of magic mushrooms, not far behind in the process. (A small study at Johns Hopkins University, published last year, suggested it could be four times more effective than traditional antidepressants.)

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We can be confident there have been far more than 5 million global Covid deaths | David Spiegelhalter and Anthony Masters

Estimating ‘excess’ fatalities, a more robust analysis method, puts the pandemic’s grim toll between 10m and 19m people
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On 1 November, news organisations reported the global Covid-19 death toll had exceeded 5 million. But, as these articles highlight, this figure is likely to be a massive underestimate.

Johns Hopkins University collates official daily statistics on Covid deaths, but there is no unified global definition: Belgium’s high reported death rate partly reflects its including all probable Covid deaths in all settings, while Hungary only publishes hospital deaths with a positive test. Turkmenistan and North Korea have, apparently, not experienced a single Covid death.

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‘Our notion of privacy will be useless’: what happens if technology learns to read our minds?

The promise of neurotechnology to make lives better is growing. But do we need a new set of rights to protect the integrity of our minds?

“The skull acts as a bastion of privacy; the brain is the last private part of ourselves,” Australian neurosurgeon Tom Oxley says from New York.

Oxley is the CEO of Synchron, a neurotechnology company born in Melbourne that has successfully trialled hi-tech brain implants that allow people to send emails and texts purely by thought.

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SpaceX toilet leak forces astronauts to use diapers on trip back to Earth

  • Crew who grew first chilis in space face 20 hours in capsule
  • ‘Spaceflight is full of lots of little challenges’, US astronaut says

Astronauts who will leave the International Space Station on Sunday will have to use diapers on the way home, because of a broken toilet in their SpaceX capsule.

The Nasa astronaut Megan McArthur described the situation as “suboptimal” but manageable. She and three crewmates will spend 20 hours in the capsule, from the time the hatches are closed until a Monday morning splashdown.

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Cranberry juice won’t cut it: UTIs and the potential for repurposing drugs

The winning essay in the Max Perutz science writing award 2021, published below, was written by Vicky Bennett from the department of biology and biochemistry at Bath University

In May, PhD students who are funded by the Medical Research Council (MRC) were invited to enter the Max Perutz science writing award 2021 and write a compelling piece about their research for the non-scientific reader.

From the many entries received, the 10 that made the shortlist covered diverse topics, including dementia, childhood adversity, the role of genes in schizophrenia and the use of hypnosis to treat psychosis.

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Welsh study shows impact of Covid on 10- and 11-year-olds

Children ate less healthily, took less exercise and had more emotional problems, say researchers

Children in the UK ate fewer vegetables, took less exercise and experienced worsening emotional difficulties following the Covid outbreak, according to a research study.

A biennial survey conducted by investigators at Cardiff University found that primary school-age children reported a sharp increase in “elevated or clinically significant emotional difficulties” in early 2021, compared with the same survey conducted in 2019.

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UK is first to approve oral antiviral pill to treat Covid

Pill can be taken twice daily at home and priority will be given to elderly patients and those with health vulnerabilities

The UK medicines regulator has become the first in the world to approve an oral antiviral pill for Covid in a move that paves the way for tens of thousands of vulnerable patients to receive the treatment from this winter.

Nearly half a million doses of molnupiravir, a pill that can be taken twice daily at home, are due for delivery from mid-November and will be given as a priority to elderly Covid patients and those with particular vulnerabilities, such as weakened immune systems. The drug will initially be given to patients through a national study run by the NHS.

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‘It gave me an ability to enjoy life’: readers on cognitive behavioural therapy

Two people tell us about their experiences with CBT and how it changed their lives

The psychotherapist Aaron Beck, known as the father of cognitive behavioural therapy (CBT), died on Tuesday aged 100 at his Philadelphia home. CBT is a form of treatment that helps patients to analyse and manage negative thinking patterns rather than focusing on past conflicts. Here, two people tell us about their experiences with CBT and how it changed their lives.

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‘He was adamant he didn’t want it’: the pro-vax parents with vaccine-hesitant kids

Among under-18s, vaccine uptake is low, and there is a growing issue with misinformation spread on social media and at school. Is there anything a concerned caregiver can do?

Throughout the pandemic, Anna has worked for the NHS. She has seen the effects of Covid-19 first-hand and, although she worked remotely because she was in a vulnerable group, other colleagues – she is a physiotherapist – were deployed to Covid wards at the height of hospital admissions. “At the trust I work for, they’re setting up a long-Covid service,” she says. She comes home and her son Sam, 16, listens to her talk about it – and yet he is adamant that the coronavirus isn’t happening or that, if it is, it’s not serious. “You know: ‘Covid is a load of rubbish – it’s all about control’,” she says. “It’s all very conspiracy theory, a lot of his stuff.” He was adamant from the start that he wouldn’t be having the vaccine if and when it became available for his age group, and he has stuck to it. “He is very resistant,” says Anna. “He is pretty determined not to conform anyway. Part of it, I think, is him being a teenager, and the other bit of it is conspiracy theory: ‘It’s all a big con.’” His main source of information since the start of the pandemic has been social media, says Anna. “He watches a lot of YouTube.”

Just over a month ago, YouTube announced it would remove videos that spread misinformation about all vaccines, and would ban the accounts of anti-vax activists; it had already banned content with false claims about Covid vaccines last year. Facebook did the same in February this year, though a quick search reveals misinformation is still easy to find (one post I found within minutes claimed 80% of vaccinated women had miscarriages). On TikTok, “unvaxxed” content racks up hundreds of thousands of views. Last month, NewsGuard, an organisation that rates the credibility of news organisations and monitors misinformation, found Covid conspiracy theories were being viewed by millions on TikTok, and, in its research, children under 13 – the lower age limit – were able to access the app.

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Plant in traditional Samoa medicine could be as effective as ibuprofen, study shows

Researchers say leaves of the matalafi plant could also potentially be used to treat cancer, diabetes and cardiovascular diseases

Leaves from a plant which can be found “in back yards across Samoa” could be as effective as ibuprofen in lowering inflammation and could even be used to treat illnesses such as Parkinson’s and cancer, a new study has found.

For centuries, the leaves of the psychotria insularum plant, known locally in Samoa as matalafi, have been used in traditional medicine to treat inflammation associated with fever, body aches, swellings, elephantiasis, and respiratory infections.

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Bill Gates call for huge global effort to prepare for future pandemics

Microsoft founder says research and development budgets should focus on weaknesses exposed by rapid spread of Covid

A global research effort worth tens of billions of dollars is needed to ensure the world is better prepared for the next pandemic, which could be far worse than Covid, Bill Gates has said.

The Microsoft founder said the “completely horrific” death toll and economic damage inflicted by coronavirus should drive funding into projects aimed at improving vaccines, treatments and diagnostic tests that will be needed to contain the next pandemic more effectively.

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Covid has caused 28m years of life to be lost, study finds

Oxford researchers arrive at virus’s toll in 31 countries by looking at deaths and age they occurred

Covid has caused the loss of 28m years of life, according to the largest-ever survey to assess the scale of the impact of the pandemic.

The enormous toll was revealed in research, led by the University of Oxford, which calculated the years of life lost (YLL) in 37 countries. The study measured the number of deaths and the age at which they occurred, making it the most detailed assessment yet of the impact of Covid-19.

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