Tuberculosis breakthrough as scientists develop risk prediction tool

Data from tens of thousands of people around the world used to identify those at highest risk of active TB before they get sick

Scientists have developed a new tool to predict the chances of a person developing tuberculosis, which could help limit the spread of the disease and improve the life chances of millions of people .

Researchers at University College London (UCL) said they believe they have produced an algorithm that could help eliminate the disease in some countries.

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Covid-19: what can we learn from the HIV/Aids pandemic? – podcast

Prof Ravi Gupta’s career has informed HIV treatment and curative strategies in the UK and at the Africa Health Research Institute. His treatment of a London patient is, to date, only the second ever successful treatment of an HIV patient, where the person remains long-term virus free. Gupta talks to Sarah Boseley about how a career in HIV research is informing the testing and treatment for Covid-19 and what we can learn in any parallels between the two viruses

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Government urged to sell cocaine and ecstasy in pharmacies

Campaigners say sale of drugs should be nationalised to undermine organised crime

Cocaine, ecstasy and amphetamines should be “nationalised” and sold legally in government-run pharmacies to undermine global drug-related crime, a UK drugs reform charity has recommended.

In a book – with a foreword written by the former prime minister of New Zealand Helen Clark – the drugs liberalisation campaign group Transform has sought to set out practical ways to sell the drugs in state-run special pharmacies as an alternative to what it calls the “unwinnable war against drugs”.

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Greater Manchester given midday Tuesday deadline for tier 3 deal

Government says it will impose tier 3 restrictions on the region if no agreement reached

The strictest Covid restrictions will be imposed on nearly 3 million people across Greater Manchester if no deal is reached by midday on Tuesday, the government has said in a dramatic ultimatum.

The communities secretary, Robert Jenrick, warned northern leaders late on Monday night that if they fail to agree to pub closures and a ban on household mixing, the tier 3 measures will be brought in unilaterally.

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Revealed: chaining, beatings and torture inside Sudan’s Islamic schools

Two-year BBC News Arabic investigation uncovers horrific conditions, with boys as young as five facing violence and sexual abuse

An April evening in the suburbs of Khartoum. After months of undercover work, I had learned to time my visits to khalwas, Sudan’s Islamic schools, to coincide with evening prayers. I entered while the sheikhs (teachers) and 50-odd boys dressed in their white djellabas were busy praying. As they knelt, I heard the clanking of chains on the boys’ shackled legs. I sat down behind them and started filming, secretly.

I began investigating after allegations emerged of abuse inside some of these schools: children kept in chains, beaten and sexually abused. Khalwas have existed in Sudan for centuries. There are more than 30,000 of them across the country where children are taught to memorise the Qur’an. They are run by sheikhs who usually provide food, drink and shelter, free of charge. As a result, poor families often send their children to khalwas instead of public schools.

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Revealed: Sheikh Khalifa’s £5bn London property empire

Documents reveal UAE president owns multibillion-pound property portfolio spanning London’s most expensive neighbourhoods

The row of 1960s-built houses with untidy gardens on a quiet cul-de-sac near Richmond upon Thames appears to have little in common with Ecuador’s red-brick embassy in Knightsbridge, where Julian Assange spent seven years in hiding, just across the road from Harrods.

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Churches tally up their value to society – at £12.4bn

From food banks to youth clubs, the C of E hosts 35,000 projects. Now a price has been put on its contribution

Sixteen years ago, St Stephen’s church in Bradford was on the verge of closure. Its congregation had dwindled to half a dozen, and the building – a “big old barn of a place”, in a predominantly Muslim area – was in poor repair. “People thought it had had its day,” said the Rev Jimmy Hinton.

Now, St Stephen’s is a vital hub, providing support and activities in an area of acute deprivation. The nave has been cleared of its pews, and heating has been installed. On a typical day, you might find an exercise class, a support group for asylum seekers and refugees, community meals being cooked and served, singing and stories for infants, mosaic-making, and people hunting for jobs or claiming benefits online.

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Greater Manchester lockdown delay ‘could lead to overwhelmed hospitals’

Stretford and Urmston MP urges government to strike deal with local leaders over tier 3 financial aid

Downing Street must urgently strike a deal with Greater Manchester leaders to introduce tougher Covid restrictions before hospitals are overwhelmed, the shadow education secretary, Kate Green, has said.

Deputy mayors and other civic leaders in the metropolitan region said in a joint statement on Friday they were “ready to meet at any time” with the prime minister to agree a way forward over the introduction of a tier 3 lockdown. They say the government’s initial proposals did not provide adequate financial support.

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Covid reinfections ‘to be expected’ as virus spreads, say government scientists

Reports suggest timeframe between recovery and reinfection ‘relatively short’ for those who contracted virus twice

Government science advisers have warned that reinfections with Covid-19 are “to be expected” as the virus spreads, based on what is known about people’s immunity to other coronaviruses that cause the common cold.

Researchers on the Covid-19 Genomics UK Consortium said it was unclear at what point people who had recovered from the virus became vulnerable to reinfection, but cited emerging reports of second infections that suggested the timeframe was “relatively short”.

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Wales facing ‘circuit breaker’ lockdown of two or three weeks

First minister says countrywide restrictions are top option being considered

Wales is facing a “circuit breaker” lockdown of two or three weeks to stop hospitals being overwhelmed, as the country reaches what the government described as a “critical point”.

Ministers will spend the weekend coming to a final decision on their next steps, but the Welsh first minister, Mark Drakeford, said on Friday a “fire-break” or circuit breaker for the whole country was the option most actively being considered.

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Remdesivir has very little effect on Covid-19 mortality, WHO finds

Results of major trial described as sobering, with drug found not to improve survival rates

Remdesivir, one of the big treatment hopes for Covid-19, has very little effect on preventing deaths, according to a large and comprehensive trial run by the World Health Organization.

The drug, made by the US biotech firm Gilead, has been talked up as a potential cure and was taken by Donald Trump. A trial in the US had previously showed it reduced the length of stay in hospital. But the gold-standard Solidarity WHO trial, which was based on a far larger sample – 3,000 people on the drug, compared with as many who were not – showed remdesivir had little effect on deaths over 28 days.

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‘Call out the lies’: UK charities hit back over bids to blame refugees for housing crisis

Far-right harassment of asylum seekers and refugees in emergency accommodation comes as Home Office gears up for mass evictions

Thousands of asylum seekers and refugees temporarily housed in emergency accommodation across the UK are being “unfairly and inaccurately” blamed for the national housing crisis, according to a coalition of more than 100 housing organisations.

Charities including Shelter, Homeless Link and the Big Issue say the housing emergency is the fault of the government, not those who have fled trafficking, violence and conflict.

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Coronavirus: what has changed about what we know? – video explainer

Covid-19 has spread around the world, sending millions of people into lockdown as health services struggle to cope. From symptoms and long Covid to vaccines and treatments, the Guardian's health editor, Sarah Boseley, explains what we now know about the virus that we did not at the beginning of the crisis

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London to face tighter Covid restrictions from Friday night

No 10 also set to extend tier 3 lockdown measures to Greater Manchester as cases rise

London will be placed in high-risk, tier 2 coronavirus restrictions from Friday night as infection rates in the capital continue to increase, MPs and the mayor of London, Sadiq Khan, have confirmed.

The decision came as Boris Johnson was expected to sign off on the harshest tier 3 coronavirus measures for millions more people in the north of England later on Thursday, with Downing Street putting last minute pressure on local leaders in Greater Manchester to accept the changes.

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Covid could overwhelm NHS without more curbs, northern leaders told

Decision expected on whether to extend tier 3 rules to Greater Manchester and Lancashire

Deaths from coronavirus will continue to rise for at least three weeks and the NHS risks being overwhelmed unless the strictest curbs are imposed on another 4 million people, leaders in northern England have been told.

A decision on whether to extend tier 3 restrictions – closing pubs and restaurants and banning household mixing – to Greater Manchester and Lancashire is expected on Thursday.

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What has gone wrong with England’s Covid test-and-trace system?

It was supposed to be ‘world beating’ but experts say it is having only a ‘marginal impact’

When the NHS test-and-trace system was launched in late May, Boris Johnson promised it would help “move the country forward”. We would be able to see our families, go to work and stop the economy crumbling.

In the absence of a vaccine, the prime minister’s “world-beating” system would be worth every penny of the £10bn funding that Rishi Sunak announced in July. The chancellor said it would enable people to carry on normal lives.

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Ending world hunger by 2030 would cost $330bn, study finds

Research suggests that by targeting enhanced aid money more effectively and with greater innovation, a solution is possible

Ending hunger by 2030 would come with a price tag of $330bn (£253bn), according to a study backed by the German government.

Research groups compiled data from 23 countries and found international donors would need to add another $14bn a year to their spending on food security and nutrition over the next 10 years; more than twice their current contribution. Low and middle-income countries would also have to give another $19bn a year, potentially through taxation.

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England’s simpler three-tier Covid system may not be enough

New rules should cut infection rates but are too late and open to abuse, say scientists

The three-tier Covid alert system is a significant shift in the government’s approach to the coronavirus crisis in England, and, while scientists broadly welcomed the simplified rules, there are concerns the restrictions come too late and are open to abuse.

A major benefit of the new system is that it clears up the confusing and messy patchwork of different rules in different places, which arose as regions in northern England, the Midlands and other parts of the country battled to contain local outbreaks. With simplicity and stability should come better compliance, and with that more control of the epidemic.

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Trans woman struggled to get help for mental illness before death, inquest told

Family of Alexandra Greenway say she was passed ‘pillar to post’ and not given psychiatric support

The family of a transgender woman who was found dead at her flat in Bristol have said at her inquest that she was passed from “pillar to post” in her efforts to seek help for her mental illness.

Alexandra Greenway’s relatives told the inquest the 23-year-old recruitment consultant did not receive the psychiatric support she required before her death on 11 May last year.

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Meghan: ‘I’m told I was the most trolled person in the world’

Duchess of Sussex speaks of ‘almost unsurvivable’ online abuse she has experienced

The Duchess of Sussex has revealed she was told last year that she was the “most trolled person in the entire world” in a podcast in which she opened up about the “almost unsurvivable” online abuse she has experienced.

Meghan and her husband, Prince Harry, joined three Californian high school students during an episode of their podcast, Teenager Therapy, and discussed topics including mental health stigma, self-care and online abuse.

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