Study of new personalised cancer therapies could ‘transform’ how the disease is treated

Large-scale clinical project could give real-time view of how well treatments are working and lead to earlier diagnoses

Scientists are embarking on a large-scale clinical study of new personalised cancer therapies which could give clinicians are real-time view of how well treatments are working.

The £9m partnership between the Francis Crick Institute, five NHS trusts, charities and bioscience companies will spend four years examining the effectiveness of new immunotherapy treatments and exploring new ways to detect cancer.

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Parkrun at 20: how a gentle jog turned into a 5km Saturday morning obsession

The event, which is celebrating its anniversary, has grown into a global phenomenon – and made us feel a whole lot better

Twenty years ago, on a windy, autumnal Saturday morning, 13 runners showed up to a park in south-west London for an event called the Bushy Park Time Trial. A 5km course was plotted and the organiser, Paul Sinton-Hewitt, a computer programmer who grew up in South Africa, bought washers from a hardware store to hand out as finish tokens. The times were tapped up on a laptop afterwards in a local Caffè Nero.

This Saturday, the weather hadn’t much improved – overcast, with the sun straining to peek through – and the venue was the same: picturesque Bushy Park with its resident red deer squaring up, ready to rut. But pretty much everything else about the impromptu get-together has evolved. Since 2008, it has been known as Parkrun and there are now 2,500 weekly events – all 5km, all free – in 22 countries, everywhere from the slopes of Mount Etna to 25 UK prisons to the Falkland Islands. In a typical week, around 350,000 people will take part. Runner’s World hails it a “global phenomenon”.

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England urged to bring in minimum unit price on alcohol as deaths rise 10% a year

Health leaders tell government to follow Scotland and Wales on cost of cheap booze after Darzi report on death toll

Ministers are facing pressure to ­introduce minimum unit pricing for alcohol after Lord Darzi’s investigation into the NHS highlighted the “alarming” death toll in England caused by cheap drink.

Public health leaders are this weekend calling for urgent action to increase the price of cheap alcohol in supermarkets and off-licences. A two-litre bottle of cider can be bought in England for under £2, which equates to 22p per unit of alcohol.

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Royal Navy chief apologises for ‘intolerable’ misogyny in Submarine Service

Ben Key confirms several personnel have been sacked, demoted or disciplined as a result of investigations

The head of the Royal Navy has issued an unreserved apology for “intolerable” misogyny in the Submarine Service, after a series of investigations across the navy exposed sexual harassment, bullying and assault of women within its ranks.

First Sea Lord Adm Sir Ben Key said he was “truly sorry” to the women who had suffered “misogyny, bullying and other unacceptable behaviours” while serving their country. “We must be better than this and do better than we have,” he said.

Senior figures forced juniors to tell them ‘shagging dits’, or personal sexual stories.

“Sniffing”, the practice of following the few women around, was “rife”, with women seen as “legitimate targets”.

“At least” one report of rape.

Those in command forced juniors to show them “sports photos”, compromising pictures of their partners, before allowing them to leave the room.

Women’s underwear going missing.

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Cabinet set for split over support for England and Wales assisted dying bill

Some senior ministers expected to vote against measure in free vote, while others are still undecided

MPs backing a new bill to legalise assisted dying in England and Wales hope to secure a Commons vote by Christmas, but cabinet ministers are set for a big split over support for the legislation.

The bill, due to be brought forward by the Labour backbencher Kim Leadbeater this month, is to be a free vote but some senior cabinet ministers are expected to vote against – and several, including the chancellor, Rachel Reeves, and the health and social care secretary, Wes Streeting – remain undecided.

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Dutch feminists campaign for national monument to ‘witches’

Thousands have been raised for site to commemorate victims of Satanic panic in 15th to 17th centuries

Three feminist campaigners in the Netherlands want to reclaim the insult “witch” and recognise the innocent victims of Dutch witch-hunts from the 15th to the 17th centuries with a national monument.

Susan Smit, Bregje Hofstede and Manja Bedner, the chair and board members of the National Witches Monument foundation, have raised €35,000 (£29,000) for an official site of memory for about 70,000 people who died during a Satanic panic that swept Europe and the Americas.

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UK toddlers get nearly half their calories from ultra-processed food, study finds

Review also finds by the time children are seven, 59% of calories come from UPFs

Toddlers in the UK obtain almost half of their calories from ultra-processed foods, rising to 59% by the age of seven, according to the largest study of its kind.

The first comprehensive review of dietary intake at such an early age comes amid rapidly rising global consumption of UPF such as cereals, protein bars, fizzy drinks, ready meals and fast food. The findings were published in the European Journal of Nutrition.

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White women added to NHS eligibility list to donate stem cells

Health service aims to sign up 30,000 people a year to meet rising demand and reduce use of more expensive imports

Millions of women are now eligible to donate stem cells on the NHS for the first time amid rising demand for life-saving transplants and a drive to reduce reliance on expensive imports.

Previously, only men aged 17 to 40 or women of Asian, black or mixed heritage aged 17 to 40 could join the NHS stem cell donor register. Now, all white women aged 17 to 40 are able to sign up.

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Tories challenge other Labour ministers to follow Keir Starmer in paying back donations – UK politics live

The prime minister said he’d paid back £6,000 worth of gifts and hospitality, including Taylor Swift tickets and his wife’s rented clothing

The UK has agreed to hand over the Chagos Islands to Mauritius, ending years of bitter dispute over Britain’s last African colony, Haroon Siddique reports.

Today’s homelessness figures highlight the need for the government to press on with banning no-fault evicitions, campaigners say.

It’s frankly ridiculous section 21 still exists – we’re approaching 6 years since the previous government first promised to abolish it, while every indicator on the dashboard has been going in the wrong direction. And now we discover homelessness caused by evictions is up almost 5% on the previous year. It’s clear from today’s data that that the renting crisis is driving the homelessness crisis …

Amid this escalating social crisis, the government’s renters’ rights bill is absolutely crucial. This legislation is a significant improvement on the last government’s effort. As drafted it will already make a difference for a lot of people.

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Migration during adolescence linked to increased psychosis risk, study finds

Risk found to be highest among black and north African people, as experts call for better mental health provision

People who migrate in adolescence have an increased risk of psychosis, researchers have found, noting the link is particularly strong among black and north African people.

While research has previously suggested migration could play a role in the increased risk of psychosis among people from ethnic minorities, the study suggests age could be an important factor.

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‘Life is pretty brutal’: concerns in India over high-pressure corporate jobs

The death of a young chartered accountant has highlighted a work culture of overworked employees and bullying bosses

For the average Indian, the working week is now longer than ever – totalling almost 47 hours.

According to recent labour data, India now has one of the most overworked labour forces in the world, enduring longer hours than in China, Singapore and even Japan, a country renowned for its relentless work culture. On average, Indians work 13 hours longer every week than an employee in Germany.

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Targeted support could reduce infant mortality gap across England, study finds

Researchers say interventions could address key factors, such as smoking, but ‘structural changes’ also needed

Four key factors have been identified that together account for more than one-third of the inequalities in infant deaths between the most and least deprived areas of England.

Researchers say targeted interventions to address these factors – teenage pregnancy, maternal depression, preterm birth and smoking during pregnancy – could go a significant way to reduce inequalities, although higher-level structural changes to address socioeconomic inequality will also be necessary.

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Children in youth offender institutions in England denied access to education, report finds

Joint review by chief of Ofsted and prisons chief inspector discovers children kept in cells to avoid conflict

Children in youth offender institutions (YOIs) are being denied access to education, with too many being kept in their cells as staff struggle to keep warring youngsters apart, a damning new report has found.

It documents a worrying decline in the quality and quantity of education provided to 15 to 18-year-olds in YOIs over the last decade despite a sharp drop in the number of children being held in custody.

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Streeting considers reviving dedicated cancer strategy after Tories axed it

Health secretary is examining case for a comprehensive plan for England to tackle UK’s second-biggest killer

Wes Streeting may revive the use of a dedicated cancer strategy to tackle the UK’s second biggest killer after experts warned the Conservatives’ scrapping of it was “a disaster” for patients.

The health secretary is considering publishing a new comprehensive plan for England, amid record numbers of people being diagnosed with the disease and NHS cancer services struggling to meet demand.

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Kemi Badenoch faces backlash as Tory rivals seize on maternity pay comments

Leadership contender’s team in damage control mode after she is criticised for saying burden on business is ‘excessive’

Kemi Badenoch’s campaign was in damage control mode on the first day of Conservative party conference, as rival candidates criticised comments she made on maternity pay, saying the burden on business was “excessive” and that people should exercise more “personal responsibility”.

Badenoch, the frontrunner among party members in the four-way contest, was forced to twice clarify the comments and emphasise that she “of course” believed in maternity pay. But the comments were seized upon by other candidates, who distanced themselves from Badenoch’s words.

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Man who killed himself in Blackpool hospital was badly failed, says mother

Jamie Pearson, 27, had waited nearly 24 hours to see an NHS mental health worker after taking an overdose in August

A 27-year-old man who killed himself in a hospital toilet after waiting nearly 24 hours to see a mental health professional was badly failed by the NHS, his mother has said.

Jamie Pearson was admitted to Blackpool Victoria hospital’s A&E department after taking an overdose of high-strength painkillers on 17 August.

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Winter fuel cut savings will be far less than Reeves expected, new analysis finds

A surge in claims for pension credit will make thousands more people eligible for the payments and other benefits

Rachel Reeves has been warned that her cut to pensioner winter fuel payments risks saving hundreds of millions less than anticipated, in a new blow to her attempts to close the hole in Britain’s finances.

The chancellor and her Treasury team are already re-examining parts of a plan to crack down on non-dom tax status over concerns that it may not raise any money.

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‘Difficult from start to finish’: how Naomi Campbell’s fashion charity unravelled

Once hailed as a philanthropic marvel, Fashion for Relief ran up hefty expenses and left charity partners angry

Five years ago, a glitzy charity fundraising gala in the British Museum organised by the model Naomi Campbell was widely accepted to be a triumph. It was the toast of London fashion week and a powerful showcase for Campbell’s philanthropic mission to raise money for young people in poverty.

Awash with celebrities (the actors Naomie Harris and Pierce Brosnan, the rapper Skepta and the model Alexa Chung) and wealthy paying guests, it combined a catwalk show with a charity auction of art (drawings by Matisse, Dalí and Tracey Emin, a signed Warhol print), jewellery and luxury watches.

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Major fears over Labour’s nursery plan for 9-month-olds in schools

Early years experts warn of lack of staff, playgrounds and toilets

Primary schools may not have enough space, specialist facilities or staff to deliver the 100,000 new nursery places in England that the government has promised, early childhood experts have warned.

Labour is under intense pressure to create enough places to fulfil its promise of 30 hours of free childcare a week for eligible parents of children from the age of nine months to three years from next September – a commitment inherited from the previous government.

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British army to investigate conduct of troops in Kenya amid rape and murder claims

Defence secretary to meet family of woman allegedly killed by soldier, as ITV airs documentary alleging fresh abuses

The army is to launch an inquiry into the behaviour of British troops posted to a military base in Kenya, after multiple allegations of serious abuses committed by soldiers, including rape and murder.

The inquiry is to examine the conduct of military personnel posted to the British Army Training Unit Kenya (BATUK). It is where the soldier alleged to have murdered a Kenyan woman, Agnes Wanjiru, was posted at the time of her death in 2012.

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