From the School of Basic Medicine, Shandong University, Shandong University, Jinan, Shandong Province, China ; Key Laboratory of Cardiovascular Remodeling and Function Research & The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China ; and Department of Cardiology, Qing Dao Central Hospital, Qing Dao, Shandong Province, China .